Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial

Brown, Angela L.; Lane, Joan; Coverly, Jacqueline; Stocks, Janice; Jackson, Sarah J.; Stephen, Alison M.; Bluck, Les; Coward, Andy; Hendrickx, H.

doi:10.1017/s0007114508047727

Cited by 232 publications

(200 citation statements)

References 56 publications

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“…The third trial was carried out in 88 overweight or obese male subjects [55]. The participants were randomly assigned into two groups, treatment and control.…”

Section: Green Teamentioning

confidence: 99%

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng¹

2012

FNA

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Hyperglycemia is a pathological condition associated with prediabetes and diabetes. The incidence of prediabetes and diabetes is increasing and imposes great burden on healthcare worldwide. Patients with prediabetes and diabetes have significantly increased risk for cardiovascular diseases and other complications. Currently, management of hyperglycemia includes pharmacological interventions, physical exercise, and change of life style and diet. Food supplements have increasingly become attractive alternatives to prevent or treat hyperglycemia, especially for subjects with mild hyperglycemia. This review summarized current patents and patent applications with relevant literature on five commonly used food supplements with claims of hypoglycemic effects, including emblica officinalis (gooseberry), fenugreek, green tea, momordica charantia (bitter melon) and cinnamon. The data from human clinical studies did not support a recommendation for all five supplements to manage hyperglycemia. Fenugreek and composite supplements containing emblica officinalis showed the most consistency in lowering fasting blood sugar (FBS) or glycated hemoglobin (HbA1c) levels in diabetic patients. The hypoglycemic effects of cinnamon and momordica charantia were demonstrated in most of the trials with some exceptions. However, green tea exhibited limited benefits in reducing FBS or HbA1c levels and should not be recommended for managing hyperglycemia. Certain limitations are noticed in a considerable number of clinical studies including small sample size, poor experimental design and considerable variations in participant population, preparation format, daily dose, and treatment duration. Future studies with more defined participants, standardized preparation and dose, and improved trial design and size are warranted.

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“…The third trial was carried out in 88 overweight or obese male subjects [55]. The participants were randomly assigned into two groups, treatment and control.…”

Section: Green Teamentioning

confidence: 99%

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

Deng¹

2012

FNA

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“…Hypotensive effects have also been observed in other trials [9,13,14,44], with the suggested mechanism of action being vasodilation in response to the stimulation and amplified production of nitric oxide by the vascular endothelium. This is in agreement with the data from a study in an animal model, the stroke-prone, spontaneously hypertensive rats, in which GTCs were shown to significantly lower SBP and DBP [45].…”

Section: Discussionmentioning

confidence: 82%

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

et al. 2016

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Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ď 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.

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“…For the FA oxidation assay, the growth medium was removed, and the cell monolayers were washed three times with PBS. Next, HepG2 cells were lipid-loaded with DMEM containing 1.75 mM [1][2][3][4][5][6][7][8][9][10][11][12][13][14] C]palmitate (57 mCi/mM; Perkin Elmer) conjugated to 1 mg/ml FA-free BSA for 18 h. The medium was removed and centrifuged to remove cellular debris. It was then placed in a sealed container with a reservoir containing 0.5 ml of 1 M NaOH.…”

Section: Fa Oxidationmentioning

confidence: 99%

Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

Jun

Lee

Kim

et al. 2014

Journal of Lipid Research

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This article is available online at http://www.jlr.org increase in the fasting TG level was associated with 14% and 37% higher incidences of CVD in men and women, respectively ( 3 ). A TG level reduction of the same magnitude could be achieved by dietary interventions, possibly based on the intake of fruits, vegetables, and teas ( 4, 5 ).The ingestion of fragrant herbal teas has been suggested as a simple and effective way of preventing CVD, with green tea being the most widely used ( 6 ). Studies on the hypolipidemic effects of teas have particularly focused on the catechins in green tea as potent active compounds ( 7,8 ). However, catechins alone cannot explain the lipid-lowering effects of teas because data on the effects of catechins in human trials have not been consistently positive ( 9, 10 ). The majority of human epidemiological and interventional studies have indicated benefi cial effects of catechin on metabolic syndrome ( 11 ). However, the number of human studies in this fi eld is still considered to be limited because some published clinical studies have shown that catechin has no effects on metabolic risk factors, including insulin sensitivity and secretion, as well as on glucose tolerance, cholesterol, and TG levels ( 10 ). In addition, noncatechin phytochemicals derived from teas have been reported to exert hypolipidemic effects independently or synergistically. In particular, teas are rich in fl avor compounds, among which the terpenoids could be potent, active compounds to enhance hepatic cholesterol and FA metabolism ( 12, 13 ). However, the metabolic functions of terpenoid aroma compounds in teas have largely been ignored. Hypertriglyceridemia is an independent risk factor in the development of CVD and a key component of metabolic syndrome ( 1, 2 ). A meta-analysis showed that a 1 mM

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Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial

Cited by 232 publications

References 56 publications

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

A Review of the Hypoglycemic Effects of Five Commonly Used Herbal Food Supplements

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

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