Effects of Dietary Zinc Oxide Nanoparticles on Growth Performance and Antioxidative Status in Broilers

Abstract

Broilers in four groups were fed a basal diet supplemented with 60 mg/kg zinc oxide (60-ZnO; control), or 20, 60, or 100 mg/kg ZnO nanoparticles (20-, 60-, and 100-nano-ZnO, respectively). Compared with the controls, after 14 days, birds in the 20- and 60-nano-ZnO groups had significantly greater weight gains and better feed conversion ratios. However, the body weight of birds in the 100-nano-ZnO group was dramatically reduced after 28 days. Relative to the control group, the total antioxidant capability (T-AOC) in serum and liver tissue was significantly higher in the 20-nano-ZnO group at all time points and also significantly higher in the 60- and 100-nano-ZnO groups in serum on days 28 and 35 and in liver tissues on days 21 and 28. Compared with the controls, the activity of copper-zinc superoxide dismutase (Cu-Zn-SOD) was significantly greater in the 60- and 100-nano-ZnO groups in serum on days 28 and 35 and in liver tissues after 21 days. Catalase activity in serum samples was significantly higher in the 20- and 60-nano-ZnO groups relative to the control and 100-nano-ZnO birds, but catalase activity in liver tissue was not affected by different nano-ZnO levels. Malondialdehyde content in serum and liver tissues was significantly reduced in the 20-, 60-, and 100-nano-ZnO groups compared with that in the control group at all time points except day 42. Taken together, our data indicate that appropriate concentration of dietary ZnO nanoparticles improves growth performance and antioxidative capabilities in broilers, and 20 mg/kg nano-ZnO is the optimal concentration.

Effect of Dietary Replacement of Inorganic Zinc by Organic or Nanoparticles Sources on Growth Performance, Immune Response and Intestinal Histopathology of Broiler Chicken

“…Because of particle size of nano zinc a faster diffusion through GIT membrane has taken place to reach the cells of the intestinal lining. Our data are in agreement with those obtained by Zhao et al (2014) who stated that after 14 days, birds in the 20 and 60 nano-ZnO groups had significantly greater weight gains and better feed conversion ratios. However, the body weight of birds in the 100-nanoZnO group was dramatically reduced after 28 days.…”

“…Means within the same row of different litters are significantly different at (P < 0.05). The present data are in harmony with those obtained by Sahoo et al (2016) who indicated that organic zinc at 15ppm induced better growth than inorganic and nano zinc sources at the same supplementation level but, in contrast with those obtained by Zhao et al (2014), wherein chickens fed 20 or 60 mg/kg nano-ZnO resulted increased in body weight at all the weeks until the end of the experiments of 42 days. Also, Siddhartha et al (2016) showed that nano zinc supplementation improved broiler chicks weight.…”

“…As a result, these unabsorbed and excess minerals not utilized by the birds are excreted in the feces, and may lead to environmental concerns when poultry manure is applied to crop land as fertilizer (Aksu et al, 2010). Furthermore, high Zn supplementation may affect the balance of other trace elements in the body and reduce the stability of vitamins and other nutrients, and long-term application can cause Zn residue in the animal body (Zhao et al, 2014). Dietary strategies should be implemented to avoid overfeeding dietary nutrients without jeopardizing animal health and performance (Ferket et al, 2002).…”

Effects of sodium humate and zinc oxide used in prophylaxis of post-weaning diarrhoea on the health, oxidative stress status and fatty acid profile in weaned piglets

“…Our results are in accordance with Pieper et al (2015) who found that long-term supplementation with high dietary Zn (2425 mg/kg for 28 days) triggers oxidative stress reactions in the pancreas of weaned piglets. Similarly, Zhao et al (2014) found that while 20-60 mg/kg of ZnO nanoparticles in broiler diet stimulate antioxidative functions, a higher dose (100 mg/kg) can lead to hepatocyte damage and a gradual decrease in total antioxidant capacity in liver tissue. In support of the aforementioned results, Gazaryan et al (2002) suggested that Zn 2+ can interfere with mitochondrial antioxidant production and may stimulate the production of reactive oxygen species.…”

The Potential Ameliorative Effect of Nano-Zinc and Zinc Against Copper Hepatorenal Toxicosis in Rats

“…The permeability of N-ZnO helps to avoid the adverse gastrointestinal reactions and improve the absorption of medicine (Lucas, 2010). N-ZnO has antioxidant properties in broilers (Zhao et al, 2014). But, other researches proved that higher usage of N-ZnO can increase recurrent exposure and the risk of toxicity through ingestion, inhalation or dermal contact during use, manufacture, and disposal (Balasubramanian et al, 2010).…”