Effects of different chemical modifications on the antibacterial activities of polysaccharides sequentially extracted from peony seed dreg

Li, Xiaoli; Thakur, Kiran; Zhang, Yuanyuan; Tu, Xiao-Fang; Zhang, Ying-Shuo; Zhu, Dan-Ye; Zhang, Jianguo; Wei, Zhao‐Jun

doi:10.1016/j.ijbiomac.2018.05.082

Cited by 56 publications

(27 citation statements)

References 52 publications

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“…Paeoniflorin, as a unique chemical substance in peony plants, showed strong antibacterial effects [ 41 ]. Additionally, the polysaccharide obtained from peony seed dregs showed antibacterial activity against both Gram-positive ( B. subtilis and S. aureus ) and Gram-negative ( E. coli and S. typhimurium ) bacteria [ 42 ]. There are abundant polyphenols in the seeds of wild peony plants [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Insights into the Phytochemical Composition and Bioactivities of Seeds from Wild Peony Species

Yan

Xie

Tian

et al. 2020

Plants

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Peony is an important medicinal and ornamental plant widely cultivated in the world. Its seeds as a functional food source have attracted much more attention in recent years, and they are rich in monoterpene glycosides and phenolic compounds. To assess the application value of wild peony seeds, the main chemical composition and content, such as total phenolic content (TPC), total flavonoid content (TFC), total flavanol content (TAC), and α and γ tocopherol content, of the seeds from 12 species and 2 subspecies were systematically explored in the present study. Four different antioxidant assays (DPPH, ABTS, FRAP, and HRSA), antibacterial, and antifungal assays were also performed using various in vitro biochemical methods. The results showed that the seeds of P. delavayi, P. obovata. subsp. obovata, and P. rockii. subsp. rockii had a high content of TPC, TFC, and TAC, respectively. Twenty-five individual chemical compounds were qualitatively and quantitatively measured by HPLC-MS, with paeoniflorin being the most abundant compound in all samples. P. mairei was grouped individually into a group via hierarchical cluster analysis according to its relatively highest monoterpene glycosides and TPC content. This work has provided a basis for the development and utilization of seeds for the selection of wild peony species of dietary interest.

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Section: Resultsmentioning

confidence: 99%

Insights into the Phytochemical Composition and Bioactivities of Seeds from Wild Peony Species

Yan

Xie

Tian

et al. 2020

Plants

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“…Peony extract is a natural extract that is widely known for its antibacterial activity. According to previous studies, peony extracts have weak antibacterial and toxic properties (Li et al, 2018;Krzyściak et al, 2017). Therefore, we intended to produce a tissue control agent containing a peony extract by applying tissue control to the peony extract.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial effects of soft denture reline resin containing natural extract

Choi¹,

Kang²

2020

ijrps

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Candida albicans (C. Albicans) is one of the bacteria that reside in the oral cavity, and the ones living in medical and commercial denture resins, commonly cause diseases. Therefore, this study was conducted to confirm the antibacterial activity of C. Albicans using a denture base resin containing peony extract with antibacterial properties. Contact angle measurements and color change measurements were performed to confirm the physical change of the material added with the antibacterial agent to the denture reline resin. As a result of the antibacterial test, the experimental group exhibited antibacterial activity against C. Albicans. Compared to the optical density results, the results of the experimental group showed a significant difference. As a result of Fluorescent images showing (confocal laser microscope), the control group showed a lot of live bacteria, and no bacteria appeared in the experimental group. All group did not show any physical changes. As a result of the contact angle measurement, the surface of the experimental group was changed to hydrophilic. In addition, there was no change in the color of the denture reline resin containing peony extract. In conclusion, it was confirmed that the peony extract contained antibacterial activity of the denture resin, and further studies should be conducted on various bacteria for denture base resin disinfection.

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“…Aside from that, both Lsbl-bk1 and Lsbl-bk2 levan products, as exoploysaccharides, have beneficial potency as an antibacterial agent. Previous studies have shown that exopolysachharides with antimicrobial activity could inhibit the growth of S. aureus, E. coli, and P. aeruginosa with an inhibition zone diameter about 15-20 mm [44,46] . It has also been assumed that exopolysaccharide levans can disrupt the bacterial cell wall integrity by blocking nutrients input [36,46] .…”

Section: Discussionmentioning

confidence: 99%

Box-Wilson Design for Optimization of in vitro Levan Production and Levan Application as Antioxidant and Antibacterial Agents

Hertadi

Permatasari

Ratnaningsih

2021

ibj

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Background: Levan or fructan, a polysaccharide of fructose, is widely used in various commercial industries. Levan could be produced by many organisms, including plants and bacteria. The cloning of the gene from Bacillus licheniformis, which expressed levansucrase in Escherichia coli host, was carried out successfully. In the present study, we performed the in vitro production of levan and analyzed its potential application as antibacterial and antioxidant agents. Methods: In vitro levan production catalyzed by heterologous-expressed levansucrase Lsbl-bk1 and Lsbl-bk2 was optimized with BW design. The antibacterial activity of the produced levan was carried out using agar well diffusion method, while its antioxidant activity was tested by free radical scavenging assays. Results: The optimum conditions for levan production were observed at 36 °C and pH 7 in 12% (w/v) sucrose for levansucrase Lsbl-bk1, while the optimum catalysis of levansucrase Lsbl-bk2 was obtained at 32 o C and pH 8 in the same sucrose concentration. The in vitro synthesized levan showed an antibacterial activity within a concentration range of 10-20% (w/v) against Staphylococcus aureus, E. coli, and Pseudomonas aeruginosa. The same levan was also able to inhibit the DPPH radical scavenging activity with the antioxidant strength of 75% compared to ascorbic acid inhibition. Conclusion: Our study, therefore, shows that the optimized heterologous expression of levansucrases encoded by Lsbl-bk1 and Lsbl-bk2 could open the way for industrial levan production as an antibacterial and antioxidant agent.

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Effects of different chemical modifications on the antibacterial activities of polysaccharides sequentially extracted from peony seed dreg

Cited by 56 publications

References 52 publications

Insights into the Phytochemical Composition and Bioactivities of Seeds from Wild Peony Species

Insights into the Phytochemical Composition and Bioactivities of Seeds from Wild Peony Species

Antibacterial effects of soft denture reline resin containing natural extract

Box-Wilson Design for Optimization of in vitro Levan Production and Levan Application as Antioxidant and Antibacterial Agents

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