Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial

Abstract

Periodontal treatments including adjunctive MTZ or MTZ + AMX are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea in subjects with chronic periodontitis.

Antibiotics in the Treatment of Periodontitis: A Systematic Review of the Literature

“…e target population included generalized aggressive periodontitis (GAgP) in two studies [13,16], chronic periodontitis (CP) in three studies [12,14,15], and moderate-to-severe periodontitis in two studies [10,11]. e subgingival debridement regime ranged from a full-mouth approach in one session [13,16] to a staged approach over 14 days [11,12,14]. One study compared the full-mouth approach in two sessions within 24 hours with two sessions 21 days apart [10].…”

“…e full-mouth SRP procedure was not detailed in one study [15]. e antibiotic regimes varied too, including amoxicillin + metronidazole for one study [12], two cases comparing the amoxicillin + metronidazole with firstly metronidazole alone [14] and secondly with moxifloxacin [16], one study interested on metronidazole solely [10], one on azithromicin [11], and finally clarithromycin in two studies [13,15]. A placebo was used for control patients in all included studies.…”

“…e microbiological parameters were searched in 6 articles [10,11,[13][14][15][16]. Sites colonized by Porphyromonas gingivalis, archaea, A. actinomycetemcomitans, and/or Tannerella forsythia were assessed.…”

“…Sites colonized by archaea and its levels were assessed in one study conducted by Ramiro [14]. At 6 months, both test groups (AMX + MET or MET only) had lower percentage of sites colonized by archaea and lower mean levels of this species at initially deep pockets (PD ≥ 5 mm) than in the control group [14]. No significant difference was observed between the two test groups.…”

“…ree studies [12,14,16] considered the association of amoxicillin/metronidazole. While amoxicillin dose (500 mg) was the same in the three studies, the metronidazole dose ranged from 250 mg to 500 mg.…”