Effects of different ratios of monounsaturated and polyunsaturated fatty acids to saturated fatty acids on regulating body fat deposition in hamsters

Liao, Fang‐Hsuean; Liou, Tsan Hon; Shieh, Ming‐Jer; Chien, Yi Wen

doi:10.1016/j.nut.2009.09.009

Cited by 34 publications

(32 citation statements)

References 47 publications

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“…Consistent with our previous study, hepatic fatty acid oxidation enzymes increases in response to high MUFA and high P/S ratio oil diets. 15 In conclusion, we found that HMHR seemed to beneficially deplete white adipose tissue accumulation by decreasing plasma leptin concentrations, suppress adipose PPARg and LPL mRNA expressions and improve hepatic lipolytic enzyme activities involved in b-oxidation in DIO hamsters, whereas OO induced hepatic endogenous lipogenesis and did not reduce body fat deposition.…”

Section: Discussionmentioning

confidence: 62%

“…10,[12][13][14] Our previous finding showed that oil with a high P/S ratio was important in lowering body fat accumulation, and high MUFA oil with a high P/S ratio (HMHR; consisting of 60% MUFA of the total fatty acids with high P/S ratio of 5) may prevent high-fat diet-induced increases in body weight and body fat. 15 Compared with HMHR oil, olive oil consists of high MUFA but with a lower P/S ratio; this difference may be one of the reasons preventing fat deposition in obese animals. However, the relationship between MUFA, P/S ratios and obesity control has not been fully addressed, and it remains unclear whether a high P/S ratio could have fat-lowering benefits in obese animals.…”

Section: Introductionmentioning

confidence: 99%

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Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Liou

et al. 2010

Int J Obes

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Objective: The aim of this study was to assess the relationship between high monounsaturated fatty acids (MUFAs) with different levels of polyunsaturated-to-saturated fatty acid (P/S) ratios and body fat loss in diet-induced obesity (DIO) models. Design: Male Golden Syrian hamsters were randomly assigned to the control group (n ¼ 12) and obesity group (n ¼ 24) for 4 weeks of the high-fat DIO period; afterward, six hamsters from each group were killed. The remaining control hamsters were still fed a low-fat diet. For an additional 8 weeks, the remaining obesity hamsters were switched to a low-fat diet and subdivided into three subgroups (n ¼ 6/group): the obesity-control (ObC) group, high MUFA with high P/S ratio oil (HMHR) group and olive oil (OO) group. Serum insulin and leptin concentrations were measured, and hepatic fatty acid metabolic enzymes and adipose differentiation markers were determined using enzyme activities analysis, western blot and semiquantification reverse-transcription PCR. Results: No difference was observed in the mean energy intake through all study periods. After the DIO period, the obesity group increased in weight gain and epididymal fat weight compared with the control group. DIO hamsters in the HMLR group had significant reductions in white adipose tissue deposition and plasma leptin levels, suppression in adipose peroxisome proliferator-activated receptor-g (PPARg) and lipoprotein lipase (LPL) mRNA expressions and increases in hepatic acyl-CoA oxidase and carnitine palmitoyltransferase-I activities and mRNA levels compared with those in the ObC group. The HMHR group had upregulated phosphorylation of hormone-sensitive lipase (HSL) relative to total HSL protein levels compared with the OO group. However, the OO group had significantly elevated hepatic de novo lipogenesis compared with the HMHR group. Conclusions: HMHR seemed to be beneficial in depleting white adipose tissue accumulation by decreasing adipose PPARg and LPL mRNA expressions and mediating phosphorylation of HSL, and by improving hepatic lipolytic enzyme activities and mRNA expressions involved in b-oxidation in DIO hamsters.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Liou

et al. 2010

Int J Obes

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“…In this paper, we have shown that BioF1B Golden Syrian hamsters can be used as a model that develops clinical and histopathological manifestations of the human metabolic syndrome through dietary intervention. It is known that the dietary factors may promote multiple phenotypes,26,27 for example, the use of high-fat diets induces obesity, insulin resistance, and hyperglycemia and the use of high-fructose diets promote insulin resistance, hypertriglyceridemia, and hypertension. However, we did not monitor for reversion of the phenotypic characteristics of the animal model by replacing their diet from hyperglycemic to normal diet.…”

Section: Discussionmentioning

confidence: 99%

Diet-induced metabolic hamster model of nonalcoholic fatty liver disease

Bhathena

Kulamarva²,

Martoni³

et al. 2011

DMSO

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Background:Obesity, hypercholesterolemia, elevated triglycerides, and type 2 diabetes are major risk factors for metabolic syndrome. Hamsters, unlike rats or mice, respond well to diet-induced obesity, increase body mass and adiposity on group housing, and increase food intake due to social confrontation-induced stress. They have a cardiovascular and hepatic system similar to that of humans, and can thus be a useful model for human pathophysiology.Methods:Experiments were planned to develop a diet-induced Bio F1B Golden Syrian hamster model of dyslipidemia and associated nonalcoholic fatty liver disease in the metabolic syndrome. Hamsters were fed a normal control diet, a high-fat/high-cholesterol diet, a high-fat/high-cholesterol/methionine-deficient/choline-devoid diet, and a high-fat/high-cholesterol/choline-deficient diet. Serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, atherogenic index, and body weight were quantified biweekly. Fat deposition in the liver was observed and assessed following lipid staining with hematoxylin and eosin and with oil red O.Results:In this study, we established a diet-induced Bio F1B Golden Syrian hamster model for studying dyslipidemia and associated nonalcoholic fatty liver disease in the metabolic syndrome. Hyperlipidemia and elevated serum glucose concentrations were induced using this diet. Atherogenic index was elevated, increasing the risk for a cardiovascular event. Histological analysis of liver specimens at the end of four weeks showed increased fat deposition in the liver of animals fed with a high-fat/high cholesterol diet, as compared to animals fed with the control diet.Conclusion:Our study established that hamsters fed with a high-fat/high-cholesterol diet developed fatty liver and mild diabetes. Bio F1B hamsters fed with a high-fat/high-cholesterol diet may thus be a good animal model for research on the treatment of diet-induced metabolic syndrome complicated by nonalcoholic fatty liver disease.

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“…For instance, diets high in trans fatty acids can increase visceral fat, liver lipid accumulation (Dorfman et al., 2009), and low‐density lipoprotein (LDL) cholesterol and decrease high‐density lipoprotein (HDL) cholesterol (Lichtenstein et al, 1999). In hamsters, it has been found that a combination of low monounsaturated fatty acid (MUFA) and low polyunsaturated fatty acid (PUFA) to saturated fatty acid (SFA) ratio induces weight gain and body fat accumulation, while a high MUFA and high PUFA/SFA ratio prevent white adipose tissue accumulation (Liao et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

“…Canola and soybean oils were used in this study because of their different fatty acid profiles as well as their different n − 6/ n − 3 ratios (canola oil: 2.2, soybean oil: 7.8), which have been shown to have different impacts on lipid metabolism in rodents (Lee et al, 1989; Liao et al., 2010). This study also focused on the activity of PEMT and protein expression of CT, the two hepatic enzymes involved in phosphatidylcholine synthesis, and other critical components of metabolic lipid processes, after CFAM administration.…”

Section: Introductionmentioning

confidence: 99%

Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat

Mboma

Leblanc

Wan

et al. 2018

Food Science & Nutrition

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Cyclic fatty acid monomers (CFAM) generated through domestic or industrial heating of vegetable oils may alter liver enzymes and induce hepatomegaly and steatosis, but the underlying mechanisms are not clearly understood. This study aimed to assess the effects of CFAM on liver and plasma lipids and to determine whether these effects are modulated by dietary lipids. Thirty‐six (36) male Wistar rats were fed either of the four isoenergetic diets consisting of canola oil or soybean oil with/without 500 mg/100 g CFAM of total fat for 28 days. Rats fed CFAM had higher liver total lipids (p = 0.03) and triacylglycerols (TAG) (p = 0.02), but less hepatic phosphatidylcholine (p = 0.02) compared to those fed the non‐CFAM diets. CFAM did not alter liver phosphatidylethanolamine N‐methyltransferase (PEMT) activity and CTP: phosphocholine cytidylyltransferase (CT‐α) protein levels. Rats fed CFAM diets had higher levels of plasma total cholesterol (TC), VLDL + LDL cholesterol, higher ratio of TC to HDL cholesterol, and lower levels of HDL cholesterol compared with rats fed non‐CFAM diets (p < 0.05). Plasma alanine transaminase (ALT) was decreased with CFAM, but plasma insulin, glucose, and TAG did not vary among the four diet groups (p < 0.05). Rats fed canola oil and CFAM had higher plasma levels of aspartate transaminase (AST) and AST/ALT ratio compared with the other three diet groups. These results indicate that CFAM may provoke an accumulation of TAG in the liver related to a decrease in phosphatidylcholine (PC) levels, but the effect of CFAM on PC concentrations may not occur through impairment of the two main PC biosynthesis pathways.

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Effects of different ratios of monounsaturated and polyunsaturated fatty acids to saturated fatty acids on regulating body fat deposition in hamsters

Cited by 34 publications

References 47 publications

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Diet-induced metabolic hamster model of nonalcoholic fatty liver disease

Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat

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