Effects of Different-Term Acute Swimming Exercises on Oxidative Stress Parameters in Rat Cerebellum Tissue

Abstract

Background: Regular physical activity may prevent the onset of a large range of pathological conditions, from heart diseases to mental disorders (depression, anxiety, panic disorder, social phobia, etc.), ischemia, and neurodegenerative diseases. Although beneficial effects of exercise are not known exactly for molecular mechanisms, several hypotheses have been proposed about this research. The purpose of this study is to examine the acute effects of oxidative stress parameters on the cerebellum tissue of the different swimming exercises. Methods:Telve week-old male Albino Wistar rats (n = 32) were used in this study. Rats were divided randomly into four groups: control, short-term exercise (15 mins.), moderate-term exercise (30 mins.), and long-term exercise (60 mins.) group. Glass tank containing water for swimming exercise (L x W x H, 100 x 50 x 50 cm) was used as pool. Results:The differences among superoxide dysmutase (SOD), glutathione (GSH), and malondialdehyde (MDA) were studied. When the difference were examined between SOD levels, short-term and moderate-term exercise groups were statistically significant different from other groups (p < 0.05). When GSH levels were examined, moderate-term and long-term groups were statistical different than other groups (p < 0.05). When MDA levels were examined, all exercise groups being compared with the control group had statistically significant differences (p < 0.05).Conclusions: SOD, GSH, and MDA levels were found to be higher in the moderate-term exercising rat's cerebellum tissue compared to rats that other groups.