Effects of different types of protein supplementation on serum albumin levels in hemodialysis patients

Abstract

Objectives: The objective of this study was to evaluate the nutritional status and protein intake of hemodialysis patients and to compare different supplementation strategies designed to recover the nutritional status and quality of life of these patients. Methods:Fifteen patients undergoing hemodialysis at a clinic in a city of São Paulo state with serum albumin levels of less than 3.8 g/dL were evaluated. For the classification of nutritional status, the patients were submitted to anthropometric assessment for body mass index calculation and responded to the 7-point subjective global assessment scale. A 24-hour dietary recall was obtained for the evaluation of food intake and the nutritional composition of these foods was calculated using the Dietpro 5i software. The patients were divided into three intervention groups that received three different protein supplements: HDMax®, Albumax®, and 100% Whey®. Results:The population studied had a mean age of 57.2 ± 16.79 years and a mean BMI of 27.9 ± 7.63 kg/m². Analysis of food intake showed a low intake of protein, which was positively correlated with low serum albumin levels (p<0.0159). A significant increase in serum albumin concentration of the participants was observed after supplementation, irrespective of the supplement used (p=0.0075). Conclusion:The present study permits to conclude that protein supplementation increases serum albumin in hemodialysis patients and consequently improves the nutritional status of these patients.Correspondence to: Fabíola Pansani Maniglia, 201 -Parque Universitário,

Effects of Two Types of Protein Supplementation in Patients on Peritoneal Dialysis

“…This result is in line with the findings of Moscardini, Finzetto e Maniglia, in which hemodialysis patients received the same supplements used in the present study [27]. Other researchers who investigated the effects of protein supplementation on hemodialysis and peritoneal dialysis patients also found an increase in serum albumin levels.…”

Association Between Oral Nutritional Supplements and Serum Biomarkers on Hemodialysis Patients. A Retrospective Study

“…The failure of conservative treatments in individuals with ESRD leads to the introduction of renal replacement therapy including renal peritoneal dialysis (PD), transplantation, and HD to maintain the quality of life of the patients (4). HD is a dialysis modality that permits the intermittent removal of toxic substances, fluid, and solutes (5).…”

“…Inside the filter, the blood encounters the dialysis solution through a semipermeable membrane. During this circulation, the filter removes toxins, and solutes and the clean blood returns to the patient (4)(5)(6). Elevated serum calcium levels and hyperphosphatemia could result in vascular calcification which is associated with cardiovascular diseases and increases the mortality rate in HD patients (7)(8).…”

“…Nutritional imbalances are common in HD patients, around 10 to 70% of HD patients will present with signs of malnutrition (4,15). Morbidity and mortality rates in this population are influenced by protein malnutrition (16).…”

“…A fivefold increase in mortality risk was observed in patients with serum albumin concentrations between 3.01 and 3.5 g/dL. Some researchers suggested that low albumin concentrations are a consequence of deficient calorie and protein intake (4,21,22). Other studies recommended HD patients be advised to consume their daily recommended amount of protein.…”