Effects of different types of input waveforms in patient-specific right coronary atherosclerosis hemodynamics analysis

Bernad, S. I.; Bernad, Elena; Barbat, Tiberiu; Albulescu, V.; Susan-Resiga, Romeo

doi:10.2495/dne-v5-n2-142-159

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…An alternative means for invasive flow measurements is presented by the calculation of models in which blood flow can be virtually simulated, a method that is called computational fluid dynamics (CFD). In fact, several in vitro studies [6,10,16,17,18] have shown that CFD allows reliable physiologic blood flow simulation and measurements of WSS, wall pressure, and mass flow. A detailed hemodynamic evaluation of disturbed flow in the post stenotic region may give additional insight of the progression of atherosclerosis and may have useful clinical value, such as early detection of a highly stenosed artery segment, prediction of future disease progression, and treatment planning 2.1 Artery reconstruction A Somatom Sensation 64 Scanner (Siemens Medical Systems, Erlangen, Germany) was used in non-enhanced spiral scan technique with a slice thickness of 0.75 mm, a table feed of 1 mm/s, and an increment of 2 mm (Fig.…”

Section: Methodsmentioning

confidence: 99%

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Bernad¹,

Bernad²,

Totorean³

et al. 2015

Int. J. DNE

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Effects of serial stenosis on coronary hemodynamics are investigated in the human right coronary artery (RCA) by blood flow analysis. The 3D reconstruction of the geometry of the stenosed coronary artery uses the multislice computerized tomography serial images method. Results of the numerical analysis present the hemodynamic characteristics of the serial stenosed coronary artery throughout the flow separation, pressure drop and wall shear stress. The pressure loss associated with recirculation region created in the vicinity of each constriction was found to be large. In two stenoses the corresponding pressure gradients are around 30 mmHg and correspond to the stenosis with fractional flow reserve-FFR < 0.7 (value associated to the severe stenosis). Distal to the stenosis, flow is associated with fluctuations in the wall shear stress and vorticity. Both FFR and CFD analysis help identify intermediate lesions that require intervention and reduce unnecessary procedures with potential complications.

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Section: Methodsmentioning

confidence: 99%

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Bernad¹,

Bernad²,

Totorean³

et al. 2015

Int. J. DNE

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Numerical Simulation of Dispersed Particle-Blood Flow in the Stenosed Coronary Arteries

Kaewbumrung

Orankitjaroen

Boonkrong

et al. 2018

International Journal of Differential Equations

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A mathematical model of dispersed bioparticle-blood flow through the stenosed coronary artery under the pulsatile boundary conditions is proposed. Blood is assumed to be an incompressible non-Newtonian fluid and its flow is considered as turbulence described by the Reynolds-averaged Navier-Stokes equations. Bioparticles are assumed to be spherical shape with the same density as blood, and their translation and rotational motions are governed by Newtonian equations. Impact of particle movement on the blood velocity, the pressure distribution, and the wall shear stress distribution in three different severity degrees of stenosis including 25%, 50%, and 75% are investigated through the numerical simulation using ANSYS 18.2. Increasing degree of stenosis severity results in higher values of the pressure drop and wall shear stresses. The higher level of bioparticle motion directly varies with the pressure drop and wall shear stress. The area of coronary artery with higher density of bioparticles also presents the higher wall shear stress.

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Particle motion in coronary serial stenoses

Bernad¹,

Totorean²,

Bernad³

et al. 2013

Modelling in Medicine and Biology X

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Atherosclerosis creating a constriction can significantly alter the local blood flow dynamics. From a biological aspect, the changes that take place in the flow have a profound effect on the structure and function of the arterial wall and the development of the disease. The purpose of this paper was to non-invasively assess hemodynamic parameters such as wall shear stress, wall pressure and particle depositions with computational fluid dynamics (CFD) in coronary artery serial stenoses. A 3-D model of a serial stenosed RCA was reconstructed based on multislice computerized tomography images. Energy loss associated with such flow expansion after each constriction will be large and consequently the pressure drop will be higher. Pressure drop across the stenoses ST1 and ST3 is lower (4.62 mmHg and 4.81 mmHg respectively) during the time T2 = 0.79s, but is significant during the peak systole T1 = 0.26s. The maximum WSS in the proximal stenosis ST1 is about 254 Pa, and in the distal stenosis ST3 are 232 Pa. One diameter downstream of the each stenosis, the WSS is low because of the formation of the recirculation zone.

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Effects of different types of input waveforms in patient-specific right coronary atherosclerosis hemodynamics analysis

Cited by 6 publications

References 32 publications

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Numerical Simulation of Dispersed Particle-Blood Flow in the Stenosed Coronary Arteries

Particle motion in coronary serial stenoses

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