Effects of different types of anti- aging dietary restrictions on age- related atrial natriuretic factor changes: An immunochemical and ultrastructural study

Cavallini, Gabriella; Clerico, Aldo; Chicca, M. Del; Gori, Zina; Bergamini, Ettore

doi:10.1007/bf03324300

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…At the physiological level, caloric restriction may not prevent decrease with age of systolic functional parameters but improves diastolic functions (Taffet et al 1997). At the cellular level, caloric restriction may prevent the age-related impairment in cardiac endocrine function (Cavallini et al 1995) and mitochondrial damage (Pamplona et al 2002;Sanz et al 2005) but does not counteract lipofuscin accumulation (Del Roso et al 1991 and unpublished) and the agerelated changes in antioxidant enzyme levels and transmural distribution (Simonetti et al 1990). …”

Section: Discussionmentioning

confidence: 92%

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

et al. 2005

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Heat shock proteins (Hsps) are induced by stressful stimuli and have been shown to protect cells and organs from such stresses both in vitro and in vivo, and play a positive role in lifespan determination. An attenuated response to stress is characteristic of senescence and no Hsp induction is observed upon exposure to stress and no protective effect of a mild stress is observed in cells from aged individuals. The artificial over-expression of Hsps, can produce a protective effect against a variety of damaging stimuli in cells from aged rats or aged humans, in whom cardiovascular disease is a major cause of morbidity in older age. Here, we show that aging significantly decreases the levels of Hsp27, Hsp60, Hsp72 and Hsc70 in right atrium and left ventricle of the rat heart, both at level of protein and of mRNA. Two different caloric restriction regimens have been found to counteract in part the decrease in the levels of Hsp expression in the aged heart tissue as well as the tendency to an increase of the levels of carbonyl in cardiac proteins. Our data suggest that cardiac Hsp levels may be a determinant of longevity in rodents, and that generation of new regimens of caloric restriction may eventually show how to improve modulation of cardiac aging.

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Section: Discussionmentioning

confidence: 92%

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

et al. 2005

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“…In rat, regimens of dietetic restriction prevented the agerelated increase of ANP stores in atrial tissue and lowered plasma ANP levels (Cavallini et al 1995). To our knowledge, there are no equivalent studies in man concerning BNP or NT-proBNP.…”

Section: Association Between Female Sex and Nt-probnpmentioning

confidence: 96%

N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people

et al. 2020

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NT-proB-type natriuretic peptide (NT-proBNP) increases with age and is associated with all-cause mortality. With this study, we assessed its possible utilization as a marker of biological age in comparison with other variables. The study included 1079 non-institutionalized elderly subjects (mean age 72.8 ± 5.5 years, 561 women). Baseline measurements were performed of serum NT-proBNP and of some laboratory variables previously utilized to estimate biological age (creatinine, albumin, C-reactive protein, cholesterol, blood glucose, leukocytes, lymphocytes, hemoglobin, mean cell volume). During 7 years of follow-up, 114 all-cause deaths occurred. The logarithm of NT-proBNP was the most age-related parameter (r = 0.35, P < 0.0001). Its relationship with mortality, according to Cox regression and ROC curve (AUC = 0.707, 95% CI 0.654-0.759), was stronger than that of all other variables, including age. In multivariate analysis, only NT-proBNP and age remained independently associated with mortality. The regression lines between age and NT-proBNP (pg/ml) allowed a separate estimation of biological age ("proBNPage") for men (= [log(NT-proBNP) + 1.2068]/0.0827) and for women (= [log(NT-proBNP) − 1.5258]/0.0478). The hazard ratio of all-cause mortality for the fifth quintile of proBNP age (≥ 85 years) compared with the first quintile (< 61 years) was 7.9 (95% CI 3.6-17.5). Similarly, the difference between pro-BNPage and chronological age was associated with a hazard ratio of 3.5 in the fifth quintile (95% CI 1.9-6.4) and was associated with disease count (P for trend = 0.0002). In conclusion, NT-proBNP was the best indicator of biological age, which can be estimated by simple formulas and might be used for prognostic purposes or as a surrogate end point in epidemiological and intervention studies.

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Towards an understanding of the anti-aging mechanism of dietary restriction: A signal transduction theory of aging

Bergamini

Gori

1995

Aging Clin Exp Res

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Effects of different types of anti- aging dietary restrictions on age- related atrial natriuretic factor changes: An immunochemical and ultrastructural study

Cited by 4 publications

References 24 publications

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

N-terminal pro B-type natriuretic peptide (NT-proBNP): a possible surrogate of biological age in the elderly people

Towards an understanding of the anti-aging mechanism of dietary restriction: A signal transduction theory of aging

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