Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Wanitschke, R.; Ammon, Helmut V.

doi:10.1172/jci108916

Cited by 37 publications

(13 citation statements)

References 36 publications

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“…Deconjugation of bile may affect fat digestion and fat soluble vitamin absorption (Knarreborg et al, 2002a) and production of lithocholic acid may be toxic to enterocytes (Knarreborg et al, 2002b;Wanitschke and Ammon, 1978). Lactobacilli are responsible for the majority of bile salt hydrolysis, although Bacteroides, Bifidobacterium, and Clostridium spp.…”

Section: Toxic Metabolitesmentioning

confidence: 99%

The Gut Microbiota: Ecology and Function

Willing

Jansson

2014

The Fecal Bacteria

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Section: Toxic Metabolitesmentioning

confidence: 99%

The Gut Microbiota: Ecology and Function

Willing

Jansson

2014

The Fecal Bacteria

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“…Moreover, bacteria may compete with the host for protein and lead to the production of ammonia [5] . Deconjugation of bile acids in the proximal gut induces fat and lipophilic vitamin (A, D, E) malabsorption and leads to the production of lithocholic acid, which is poorly absorbed and may be directly toxic to enterocytes [6] . Cobalamin (vitamin B 12 ) deficiency can occur in SIBO as a result of use of the vitamin by anaerobic bacteria.…”

Section: Metabolic Effects Of Bacterial Overgrowthmentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment

Gasbarrini

Lauritano

Gabrielli

et al. 2007

Dig Dis

140

115

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Small intestinal bacterial overgrowth (SIBO) is a clinical condition characterized by a malabsorption syndrome due to an increase in microorganisms within the small intestine. The main mechanisms restricting bacterial colonization in the upper gut are the gastric acid barrier, mucosal and systemic immunity and intestinal clearance. When these mechanisms fail, bacterial overgrowth develops. Diarrhea, steatorrhea, chronic abdominal pain, bloating and flatulence are common symptoms and are similar to those observed in irritable bowel syndrome. Breath tests (glucose and/or lactulose breath tests) have been proposed as a sensitive and simple tool for the diagnosis of bacterial overgrowth, being non-invasive and inexpensive compared to the gold standard represented by the culture of intestinal aspirates. Antibiotic therapy is the cornerstone of SIBO treatment. Current SIBO treatment is based on empirical courses of broad-spectrum antibiotics since few controlled studies concerning the choice and duration of antibiotic therapy are available at present.

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“…This process may impair formation of the bile-salt-lipid micelle complex, so that dietary fat is malabsorbed. In addition, the free bile acids formed in SBBO may be toxic to the mucosa and contribute directly to the patchy mucosal lesion of SBBO [15]. Malabsorption of fat-soluble vitamins (vitamins A, D, E, and K) may occur as a consequence of general fat malabsorption, but this is seldom of any clinical significance.…”

Section: Mechanisms Of Malabsorptionmentioning

confidence: 99%

Small bowel bacterial overgrowth: Presentation, diagnosis, and treatment

Singh

Toskes

2003

Curr Gastroenterol Rep

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Small bowel bacterial overgrowth (SBBO) syndrome is associated with excessive numbers of bacteria in the proximal small intestine. The pathology of this condition involves competition between the bacteria and the human host for ingested nutrients. This competition leads to intraluminal bacterial catabolism of nutrients, often with production of toxic metabolites and injury to the enterocyte. A complex array of clinical symptoms ensues, resulting in chronic diarrhea, steatorrhea, macrocytic anemia, weight loss, and less commonly, protein-losing enteropathy. Therapy is targeted at correction of underlying small bowel abnormalities that predispose to SBBO and appropriate antibiotic therapy. The symptoms and signs of SBBO can be reversed with this approach.

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Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.

Cited by 37 publications

References 36 publications

The Gut Microbiota: Ecology and Function

The Gut Microbiota: Ecology and Function

Small Intestinal Bacterial Overgrowth: Diagnosis and Treatment

Small bowel bacterial overgrowth: Presentation, diagnosis, and treatment

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