Effects of Discrete Brainstem Lesions in Cats on Perception of Noxious Stimulation

Melzack, Ronald; Stotler, W. A.; Livingston, W. K.

doi:10.1152/jn.1958.21.4.353

Cited by 131 publications

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“…Receptor density is highest in medially located areas associated with the paleospino thalamic and spinoreticulodiencephalic pathways, which are thought to mediate the affective component of pain perception. Examples include the high density of opiate receptors in the periaqueductal gray of the midbrain, where lesions produce analgesia (72), electrical stimulation appears to cause pain (81,106), and implanta tion of small amounts of morphine selectively relieves pain (88). Autoradiographic studies confirm these findings derived from regional dissections and biochemical assays, and further emphasize the selective localization of the opiate receptor (89).…”

Section: The Opiate Receptor: a Model For Neurotransmitter Receptor Fmentioning

confidence: 93%

Neurotransmitter Receptors in the Brain: Biochemical Identification

Snyder¹,

Bennett²

1976

Annu. Rev. Physiol.

187

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Section: The Opiate Receptor: a Model For Neurotransmitter Receptor Fmentioning

confidence: 93%

Neurotransmitter Receptors in the Brain: Biochemical Identification

Snyder¹,

Bennett²

1976

Annu. Rev. Physiol.

187

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“…Another para dox is that lesions of the periaqueductal grey may produce either hy peralgesia [29] or relief of chronic pain syndromes, although this is ex plicable by postulating different functions for different parts of the central grey. Thus the anterior portion of the periaqueductal central grey has been reported as being more likely to produce analgesia when stimulated than the posterior half.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant Activation of Pain-Suppressive Systems

Hitchcock¹,

Teixeira²

1982

Stereotact Funct Neurosurg

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The effect of diphenylhydantoin, sodium valproate and carbamezepine on the enzymatic activity of the anterior mesencephalic periaqueductal grey matter was examined by a histochemical technique using density phase measurement. Diphenylhydantoin caused the greatest reduction in glutamate dehydrogenase and GABA. Only sodium valproate increased glutamate dehydrogenase and GABA and only diphenylhydantoin an increase in semi-aldehyde dehydrogenase activity. Central pain suppressive systems can be activated by certain anticonvulsants.

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“…These results may have a bearing on the problem of the hyperpathia observed in cats with 'lesions of the central tegmental fasciculus' (Melzack, Stotler & Livingston, 1958) and should a similar mechanism exist in man, on the problem of the thalamic syndrome of Dejerine & Roussy (1906). It would be necessary to assume that in the unanaesthetized animal the ventral thalamodiencephalic region exerts a tonic inhibitory effect on the cutaneous afferent terminals synapsing with the cells of the dorsal horn.…”

mentioning

confidence: 84%

Proceedings of the Physiological Society, 22‐23 April 1966; Louvain Meeting, Belgium: Communications

1966

The Journal of Physiology

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52P PROCEEDINGS OF THE chloride was slowly added to a solution of neurophysin-M containing one of the two hormones or a mixture of both, protein-hormone complexes were precipitated in the form of needle-shaped crystals. A picture of the complex of neurophysin-M with arginine vasopressin is shown in Fig. 1.In the absence of the octapeptide hormones, neurophysin-M remained in solution. It can thus be said that the presence of hormone was a necessary prerequisite for crystallization. The molecular conformation of the complexes remains to be elucidated.In these experiments the protein concentration was 2-5 mg/ml. in a sodium acetate buffer of pH 3*9; the concentration of peptide hormone(s) was 1 mg/ml. Crystallization was achieved in a sodium chloride concentration of 2-5 % (w/v). Sensory switching mechanisms were studied in normal man by programming mixed series of somatosensory stimuli (electrical pulses on a finger of the hand) and of acoustic clicks. The corresponding cerebral evoked potentials were averaged by C.A.T. and Enhancetron digital computers while the subject performed decision tasks involving either the clicks or the finger shocks. In the latter situation the somatosensory evoked potentials show a marked increase in the voltage of later components with no significant change of the early 'primary' component (Desmedt, Debecker & Manil, 1965). Evidence will now be presented on the kinetics of the switching process. Clicks and finger shocks were made to alternate regularly at various rates, and the two computers were triggered to average 200 responses picked up respectively over the parietal hand pro-52P

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Effects of Discrete Brainstem Lesions in Cats on Perception of Noxious Stimulation

Cited by 131 publications

References 0 publications

Neurotransmitter Receptors in the Brain: Biochemical Identification

Neurotransmitter Receptors in the Brain: Biochemical Identification

Anticonvulsant Activation of Pain-Suppressive Systems

Proceedings of the Physiological Society, 22‐23 April 1966; Louvain Meeting, Belgium: Communications

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