Effects of dorsal hippocampus catecholamine depletion on paired-associates learning and place learning in rats

Roschlau, Corinna; Hauber, Wolfgang

doi:10.1016/j.bbr.2017.01.038

Cited by 3 publications

(5 citation statements)

References 57 publications

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“…Both S-R and cognitive learning strategies could be used to acquire PAL: a S-R strategy where each of the six-possible pairings are memorized (e.g., if: flower left and spider right, choose flower), or where a rule is learned and applied (e.g., the flower is always, and only, correct on the left). Although research has shown that PAL acquisition relies on an intact DSTR [21] and can occur without a functional HPC [21,27], post-acquisition performance is readily impaired by HPC disruption [21,22,27]. It is reasonable to expect that pre-acquisition HPC lesion biases animals toward an S-R strategy, but this does not exclude use of HPC-dependent strategies in intact animals.…”

Section: Discussionmentioning

confidence: 99%

“…While we theorize the improved acquisition demonstrated here is the result of preferential enhancement of DTSR-mediated S-R strategies, we cannot exclude the possibility that HPC-mediated strategies were also enhanced by stress. In contrast to other behavioural tasks which can be used to distinguish between DSTR and HPC-based learning strategies, such as the plus maze [27,33], it's likely that neither system is exclusively involved in PAL acquisition. Both S-R and cognitive learning strategies could be used to acquire PAL: a S-R strategy where each of the six-possible pairings are memorized (e.g., if: flower left and spider right, choose flower), or where a rule is learned and applied (e.g., the flower is always, and only, correct on the left).…”

Section: Discussionmentioning

confidence: 99%

“…However, while task performance in well-trained animals is impaired by manipulations of the HPC, acquisition of PAL is largely unaffected by pre-acquisition HPC lesions in mice [21,22] or by HPC catecholamine depletion in rats [27]. In contrast to later task performance, PAL acquisition may involve separate memory systems as lesions of the DSTR prevent PAL acquisition entirely [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers

Roebuck

Liu

Lins

et al. 2018

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers

Roebuck

Liu

Lins

et al. 2018

Behavioural Brain Research

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“…In one experiment using the response learning version of the plus-maze, systemic administration of either the dopamine D1 receptor antagonist SCH23390 or the dopamine D2 receptor antagonist eticlopride impaired acquisition of response learning (Daniel et al, 2006). In contrast, in a dual-solution plus-maze, catecholamine depletion in the hippocampus led to the predominant use of a response learning strategy (Roschlau and Hauber, 2017).…”

Section: Dopaminementioning

confidence: 99%

Place vs. Response Learning: History, Controversy, and Neurobiology

Goodman

2021

Front. Behav. Neurosci.

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The present article provides a historical review of the place and response learning plus-maze tasks with a focus on the behavioral and neurobiological findings. The article begins by reviewing the conflict between Edward C. Tolman’s cognitive view and Clark L. Hull’s stimulus-response (S-R) view of learning and how the place and response learning plus-maze tasks were designed to resolve this debate. Cognitive learning theorists predicted that place learning would be acquired faster than response learning, indicating the dominance of cognitive learning, whereas S-R learning theorists predicted that response learning would be acquired faster, indicating the dominance of S-R learning. Here, the evidence is reviewed demonstrating that either place or response learning may be dominant in a given learning situation and that the relative dominance of place and response learning depends on various parametric factors (i.e., amount of training, visual aspects of the learning environment, emotional arousal, et cetera). Next, the neurobiology underlying place and response learning is reviewed, providing strong evidence for the existence of multiple memory systems in the mammalian brain. Research has indicated that place learning is principally mediated by the hippocampus, whereas response learning is mediated by the dorsolateral striatum. Other brain regions implicated in place and response learning are also discussed in this section, including the dorsomedial striatum, amygdala, and medial prefrontal cortex. An exhaustive review of the neurotransmitter systems underlying place and response learning is subsequently provided, indicating important roles for glutamate, dopamine, acetylcholine, cannabinoids, and estrogen. Closing remarks are made emphasizing the historical importance of the place and response learning tasks in resolving problems in learning theory, as well as for examining the behavioral and neurobiological mechanisms of multiple memory systems. How the place and response learning tasks may be employed in the future for examining extinction, neural circuits of memory, and human psychopathology is also briefly considered.

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“…Indeed, Nithianantharajah et al (2015) demonstrated that mice and humans carrying the same disease-related genetic mutations exhibited similar cognitive impairment in paired associates learning (PAL) test paradigms. Previous studies have reported that hippocampal catecholamines, including dopamine, are involved in PAL task performance (Talpos et al, 2015; Roschlau and Hauber, 2017). Using touch panel operant systems, it may be possible to evaluate the cognitive benefits of iso-α-acids and elucidate the underlying mechanisms in rodents with high translational validity.…”

Section: Introductionmentioning

confidence: 98%

Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System

Ayabe

Ohya

Ano

2019

Front. Behav. Neurosci.

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Dementia and cognitive decline have become worldwide health problems due to rapid growth of the aged population in many countries. We previously demonstrated that single or short-term administration of iso-α-acids, hop-derived bitter acids in beer, improves the spatial memory of scopolamine-induced amnesia model mice in the Y-maze and enhances novel object recognition in normal mice via activation of the vagus nerve and hippocampal dopaminergic system. However, these behavioral tests do not replicate the stimulus conditions or response requirements of human memory tests, and so may have poor translational validity. In this report, we investigated the effects of iso-α-acids on visual discrimination (VD) and reversal discrimination (RD) using a touch panel-based operant system similar to that used for human working memory tests. In the VD task, scopolamine treatment reduced correct response rate and prolonged response latency in mice, deficits reversed by prior oral administration of iso-α-acids. In the RD task, administration of iso-α-acids significantly increased correct response rate compared to vehicle administration. Previous studies have reported that dopamine signaling is involved in both VD and RD learning, suggesting that enhancement of dopamine release contributes to improved memory performance in mice treated with iso-α-acids. Taken together, iso-α-acids improve VD and RD learning, which are considered high-order cognitive functions. Given the translational advantages of the touch panel-based operant system, the present study suggests that iso-α-acids could be effective for improvement of working memory in human dementia patients.

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Effects of dorsal hippocampus catecholamine depletion on paired-associates learning and place learning in rats

Cited by 3 publications

References 57 publications

Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers

Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers

Place vs. Response Learning: History, Controversy, and Neurobiology

Hop-Derived Iso-α-Acids in Beer Improve Visual Discrimination and Reversal Learning in Mice as Assessed by a Touch Panel Operant System

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