Effects of Doxycycline on Renal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome

İhtiyar, Enver; Yaşar, Necdet Fatih; Erkasap, Nilüfer; Köken, Tülay; Tosun, Murat; Öner, Setenay; Erkasap, Serdar

doi:10.1016/j.jss.2009.09.048

Cited by 34 publications

(22 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in a clinical study minocycline did not show significant protective effects against AKI that developed post-cardiac bypass surgery (Golestaneh et al, 2015). Doxycycline as another tetracycline antibiotics exhibited renoprotective effects by decreasing levels of IL-1β, TNF-α and MMP-2 in renal tissue against IRI induced by abdominal compartment syndrome (ACS) (Ihtiyar et al, 2011). Both minocycline and doxycycline were effective in mitigating liver and kidney injury to improve survival in the mouse model of hemorrhagic shock/resuscitation (Kholmukhamedov et al, 2014).…”

Section: Chemical Renoprotectantsmentioning

confidence: 99%

Renoprotective approaches and strategies in acute kidney injury

Yang

Song

et al. 2016

Pharmacology & Therapeutics

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a major renal disease associated with a high mortality rate and increasing prevalence. Decades of research has suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.

show abstract

Section: Chemical Renoprotectantsmentioning

confidence: 99%

Renoprotective approaches and strategies in acute kidney injury

Yang

Song

et al. 2016

Pharmacology & Therapeutics

View full text Add to dashboard Cite

show abstract

“…For example, Ihtiyar et al found that 10-mg/kg doxycycline reduced pro-inflammatory cytokine levels and metalloproteinase-2 (MMP-2) activity while increasing tissue inhibitor metalloproteinase-1 (TIMP-1) levels in a rat renal torsion model. The authors thus concluded that doxycycline prevents apoptosis due to I/R injury in renal tissue (4). Yasar et al demonstrated a similar effect in intestinal tissue (19).…”

Section: Discussionmentioning

confidence: 94%

“…It has anti-inflammatory and cytoprotective effects (5,6). Its role in preventing reperfusion injury and reducing the number of mediators produced during reperfusion has been demonstrated previously in cardiac, renal, bowel and cerebral tissues (4,7,8). Anti-apoptotic effects of doxycycline have also been found in mouse testes (9).…”

Section: Introductionmentioning

confidence: 87%

“…Microvascular dysfunction following reperfusion increases fluid filtration, leukocyte and plasma protein extravasation, and production of free oxygen radicals (3). Events occurring during reperfusion of ischemic tissue lead to increases in mediators such as TNF-alpha, interleukin-1, platelet activating factor, and nitric oxide (4). Doxycycline, a member of the tetracycline antibiotic family, inhibits mRNA transcription of the matrix metalloproteinases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Doxycycline on Aseptic Reperfusion Injury in Ovarian Torsion

Bektas

Karasu

Yurtcu

et al. 2019

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

OBJECTIVE: Reperfusion injury occurs when the condition causing ischemia in ovarian torsion is corrected and the blood supply is re-established. The aim of this study is to evaluate whether doxycycline treatment reduces reperfusion injury in a rat model. STUDY DESIGN:Thirty-five female albino Wistar rats were split into the five groups. Sham: Sham operation; ischemia (I): 2 hours of ischemia; ischemia and reperfusion (I/R): 2 hours of ischemia followed by 2 hours of reperfusion; Sham-Dc: Sham operation and doxycycline 10-mg/kg (2 hours prior to surgery); I/R-Dc: 2-hours of ischemia and doxycycline 10-mg/kg and 2-hours of reperfusion. The groups were compared in terms of histological and biochemical features. A semi-quantitative histological assessment scoring system was used for the histological examination. Follicular cell degeneration, vascular congestion, haemorrhage, and inflammatory cell count were evaluated for histological analysis. For biochemical analysis of reperfusion injury, the body's total antioxidant status and total oxidant status were measured using a fully automatic method. The oxidative stress index was calculated by dividing total antioxidant status by total oxidant status. RESULTS:In the sham group the ovaries were histologically normal. Oedema, vascular congestion, bleeding, leukocyte infiltration, and follicle degeneration were increased in other groups (p<0.05). There was less leukocyte infiltration in the I/R-Dc group compared to I/R group. Other histological features were similar in these groups. Doxycycline increased the malondialdehyde, total antioxidant and total oxidant status levels in Sham-Dc and I/R-Dc groups. This increase was statistically significant between Sham and Sham-Dc groups. However, although there was an increase in the biochemical markers in the I/R-Dc group, this increase was not significant compared to I/R group. CONCLUSION: Doxycycline treatment in ovarian torsion does not reduce I/R injury. Doxycycline may even increase reperfusion injury, according to biochemical findings.

show abstract

“…According to the literature, intraabdominal pressure > 12 mm Hg is considered to be abdominal hypertension (10). Again it has been shown that increased intraabdominal pressure as it is seen in laparoscopy is associated with the decrease in intestinal perfusion and even ischemia (11)(12)(13)(14)(15)(16)(17). Increased intraabdominal pressure was also found to decrease mesenteric blood supply (18).…”

Section: Discussionmentioning

confidence: 99%

Comparison Effect of Direct Trocar and Veress Needle Entry Techniques on Gut Functions after Laparoscopic Procedures: Randomized Clinical Trial

Şenol

Polat

Özkaya

et al. 2016

Gynecol Obstet Reprod Med

View full text Add to dashboard Cite

OBJECTIVE: The aim of this study was to compare the effect of two different laparoscopic entry methods on postoperative gastrointestinal functions. STUDY DESIGN: A total of 108 women who underwent gynecological operation via laparoscopic approach with different indications were randomly assigned to 2 groups: In Group 1 pneumoperiteneum was achieved by direct trocar entry (n=72), while in group 2, Veress needle was used. RESULTS: Correlation analyses showed a significant association between the technique for abdominal entry and postoperative hemoglobin and hematocrit concentrations, time to maximal intraabdominal pressure and the body mass index. Comparison of groups with different laparoscopic entry techniques showed a significant difference between groups in terms of postoperative hemoglobin and hematocrit concentrations, time to obtain maximal intraabdominal pressure and time to first flatulence (p < 0.05, Table 2). No intra or postoperative complications was observed. CONCLUSION: Direct or Veress needle entry methods were both safe to create pneumoperitoneum with similar postoperative gastrointestinal functions except for earlier first flatulence in Veress needle group while direct trocar entry was found to be associated with favorable postoperative blood count and shorter duration to obtain enough intraperitoneal pressure.

show abstract

Effects of Doxycycline on Renal Ischemia Reperfusion Injury Induced by Abdominal Compartment Syndrome

Cited by 34 publications

References 28 publications

Renoprotective approaches and strategies in acute kidney injury

Renoprotective approaches and strategies in acute kidney injury

Effect of Doxycycline on Aseptic Reperfusion Injury in Ovarian Torsion

Comparison Effect of Direct Trocar and Veress Needle Entry Techniques on Gut Functions after Laparoscopic Procedures: Randomized Clinical Trial

Contact Info

Product

Resources

About