Effects of early alcohol exposure upon adult learning ability and taste preferences

Phillips, David S.; Stainbrook, Gene L.

doi:10.3758/bf03326599

Cited by 53 publications

(20 citation statements)

References 13 publications

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“…For example, rats born to mothers given ethanol when pregnant tend to ingest more ethanol as pups than rats born to mothers without such experience (3,25,26). These effects are evident even when the exposure period is limited to intraperitoneal injections on day 8 of gestation (21).…”

Section: Mus Musculusmentioning

confidence: 99%

Maternal ingestion of ortho-aminoacetophenone during gestation affects intake by offspring

Nolte

Mason

1995

Physiology & Behavior

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Section: Mus Musculusmentioning

confidence: 99%

Maternal ingestion of ortho-aminoacetophenone during gestation affects intake by offspring

Nolte

Mason

1995

Physiology & Behavior

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“…Further, the outcomes of these studies have been quite varied, particularly in the older literature involving the consequences of an extensive series of prenatal ethanol exposure. Bond and DiGiusto (1976) and Phillips and Stainbrook (1976) reported clear increases in adult preference or intake of ethanol among rat offspring exposed to ethanol relatively continuously throughout gestation. However, neither Abel and York (1979) and Anton (1983) found that mouse fetuses whose dams were exposed to the drug between G8 and birth consumed more ethanol during P25-P32 (i.e., the age range of juvenile and early adolescent development) than did controls, but this effect was not seen between P33 and P46.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

“…Further, the outcomes of these studies have been quite varied, particularly in the older literature involving the consequences of an extensive series of prenatal ethanol exposure. Bond and DiGiusto (1976) and Phillips and Stainbrook (1976) reported clear increases in adult preference or intake of ethanol among rat offspring exposed to ethanol relatively continuously throughout gestation. However, neither York (1979) nor McGivern, Clancy, Mousa, Couri, andNoble (1984) found an enhanced acceptance effect.…”

mentioning

confidence: 99%

The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats.

Youngentob¹,

Molina²,

Spear³

et al. 2007

Behavioral Neuroscience

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Clinical and epidemiological studies provide strong data for a relationship between prenatal ethanol exposure and the risk for abuse in adolescent and young adult humans. However, drugacceptance results in response to fetal exposure have differed by study, age at evaluation, and experimental animal. In the present study, the authors tested whether voluntary ethanol intake was enhanced in both the infantile and adult rat (15 and 90 days of age, respectively), as a consequence of chronic fetal drug experience. Experimental rats were exposed in utero by administering ethanol to a pregnant dam in a liquid diet during gestational Days 6-20. Compared with those for isocaloric pair-fed and ad lib chow control animals, the results for experimental animals demonstrated that fetal exposure significantly increased infantile affinity for ethanol ingestion without affecting intake patterns of an alternative fluid (water). Heightened affinity for ethanol was absent in adulthood. Moreover, the results argue against malnutrition as a principal factor underlying the infantile phenomenon. These data add to a growing literature indicative of heightened early postnatal acceptance patterns resulting from maternal use or abuse of ethanol during pregnancy. Keywordsfetal ethanol exposure; postnatal ethanol affinity; ethanol abuse; ethanol drinking behavior; fetal learning It has been well established that prenatal exposure to ethanol can exert profound detrimental effects in the developing fetus. The effects can be widespread, severe, and generally permanent. Depending on timing of exposure, and its duration and dose, these include stereotypical craniofacial malformations, poor suckling reflexes, decreased birth weight NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript (Abel & Hannigan, 1995;Astley, Clarren, Little, Sampson, & Daling, 1992;Clareen & Smith, 1978;Jones, Smith, Ulleland, & Streissguth, 1973; Lemoine, Harousseau, Borteyru, & Meneut, 1968;Martin, Martin, Streissguth, & Lund, 1977;Osborn, Harris, & Weinberg, 1993;Oulette, Rosett, Rosman, & Weiner, 1977;Streissguth, Landesman-Dwyer, Martin, & Smith, 1980;Ulleland, Wennburg, Igo, & Smith, 1970;Van Dyke, MacKay, & Ziaylek, 1982), and other profound neurodevelopmental effects in the nervous system Miller, 1992b). Prenatal exposure to ethanol can cause behavioral changes, such as hyperactivity, and learning and memory deficits: Indeed, gestational exposure is a leading known cause of mental retardation (Abel & Hannigan, 1995;Abel & Sokol, 1992;Sampson et al., 1997;Stratton, Howe, & Battaglia, 1996).The above notwithstanding, there are subtler yet potentially just as detrimental long-term consequences. Recent clinical and epidemiological studies indicate that prenatal exposure to ethanol is strongly associated with the risk for ethanol abuse in adolescent and young adult humans (Alati et al., 2006;Baer, Bar, Bookstein, Sampson, & Streissguth, 1998;Streissguth, 1998;Yates, Cadoret, Troughton, Steward, & Giunta, 1998). In effect, gestational exposure...

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“…Fecundity (the ability to produce offspring), natality (birth rates), and weight of offspring were examined in rats. Rats were selected as experimental subjects since they breed rapidly and have been shown to be sensitive to developmental perturbations when administered substances prenatally (Butcher, Vorhees, & Kimmel, 1972;Goiter & Michaelson, 1975;Havlena & Werboff, 1963;Phillips & Stainbrook, 1976).…”

mentioning

confidence: 99%

Fecundity, natality, and weight as a function of prenatal alcohol consumption and age of the mother

Phillips

Stainbrook

1978

Psychobiology

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The purpose of this study was to investigate the possible interaction between prenatal exposure to alcohol and the age of the mother upon offspring. Two groups of female rats, one who drank only water and one who drank only wine, were mated four times. The fecundity, natality, and weights of the pups were examined. It was concluded that in the rat moderate amounts of alcohol do not affect fecundity but that natality is affected. Birth weight of the pups is also affected by maternal alcohol consumption but not by the age of the mother.

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Effects of early alcohol exposure upon adult learning ability and taste preferences

Cited by 53 publications

References 13 publications

Maternal ingestion of ortho-aminoacetophenone during gestation affects intake by offspring

Maternal ingestion of ortho-aminoacetophenone during gestation affects intake by offspring

The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats.

Fecundity, natality, and weight as a function of prenatal alcohol consumption and age of the mother

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