Effects of Early and Systematic Integration of Specialist Palliative Care in Patients with Advanced Cancer: Randomized Controlled Trial PALINT

Sláma, Ondřej; Pochop, Lukáš; Šedo, Jiří; Švancara, Jan; Šedová, Petra; Světláková, Lucie; Demlová, Regina; Vyzula, Rostislav

doi:10.1089/jpm.2019.0697

Cited by 15 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We screened the titles and abstracts of the remaining 4,603 articles, and 142 were selected for full-text reading. Ultimately, 19 articles (Bakitas et al, 2009; do Carmo et al, 2017; Eychmüller et al, 2021; Franciosi et al, 2019; Groenvold et al, 2017; Grudzen et al, 2016; Johnsen et al, 2020; McCorkle et al, 2015; Patil et al, 2021; Rodin et al, 2022; Scarpi et al, 2019; Schenker et al, 2018; Slama et al, 2020; Temel et al, 2020; Vanbutsele et al, 2018; Zimmermann et al, 2014) were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…In 10 studies (Eychmüller et al, 2021;Franciosi et al, 2019;Groenvold et al, 2017;Grudzen et al, 2016;Johnsen et al, 2020;Scarpi et al, 2019;Schenker et al, 2018;Slama et al, 2020;Tattersall et al, 2014;Vanbutsele et al, 2018), researchers adopted appropriate random sequence generation and assignment methods; all other studies did not provide sufficient information. In eight studies (do Carmo et al, 2017;Maltoni et al, 2016;Rodin et al, 2022;Scarpi et al, 2019;Schenker et al, 2018;Slama et al, 2020;Temel et al, 2010;Zimmermann et al, 2014;42%) there was insufficient detail about double-blind treatment, and in 13 studies (Bakitas et al, 2009;Eychmüller et al, 2021;Groenvold et al, 2017;Grudzen et al, 2016;Johnsen et al, 2020;Maltoni et al, 2016;McCorkle et al, 2015;Patil et al, 2021;Rodin et al, 2022;Temel et al, 2010Temel et al, , 2020Vanbutsele et al, 2018;Zimmermann et al, 2014), there was a low risk of incomplete outcome data. Only two studies (McCorkle et al, 2015;Scarpi et al, 2019) were considered at high risk of reporting bias.…”

Section: Quality Assessment Of Articlesmentioning

confidence: 99%

See 1 more Smart Citation

Meta-Analysis of Effects of Early Palliative Care on Health-Related Outcomes Among Advanced Cancer Patients

Cui,

Fang,

Bai

et al. 2023

Nursing Research

View full text Add to dashboard Cite

Background Early palliative care (PC) has received more attention for improving health-related outcomes for advanced cancer patients in recent years, but the results of previous studies are inconsistent. Objectives This study aimed to use meta-analysis and trial sequence analysis to evaluate the effect of early PC on health-related outcomes of advanced cancer patients. Methods All English publications were searched in PubMed, Web of Science, Embase, and the Cochrane Library from inception to March 2023 with a restriction that the study type was a randomized controlled trial. Results The results showed that early PC positively affected quality of life, satisfaction with care, and symptom burden reduction. However, early PC had no significant effect on anxiety or survival. Trial sequence analysis results showed that the effect of early PC on the quality of life was stable. Discussion This systematic review suggested that early PC could positively affect health-related outcomes for advanced cancer patients. Early PC can be used widely in clinical settings to improve health-related outcomes of advanced cancer. However, because of the trial sequence analysis results, further well-designed, clinical, randomized controlled trials with larger sample sizes are necessary to draw definitive conclusions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Quality Assessment Of Articlesmentioning

confidence: 99%

Meta-Analysis of Effects of Early Palliative Care on Health-Related Outcomes Among Advanced Cancer Patients

Cui,

Fang,

Bai

et al. 2023

Nursing Research

View full text Add to dashboard Cite

show abstract

“…Two randomised controlled trials (RCTs) investigating EPC in patients with a mean age ≥65 years and advanced cancer were identified [18 ▪ ,19 ▪ ]. These trials are supplemented by a third clinical trial, the sample of which does not fulfil the definition of older patients but nevertheless seems well suited to illustrate the age composition in EPC studies [20]. Moreover, we found a secondary exploratory analysis of data from an RCT [21].…”

Section: Resultsmentioning

confidence: 99%

“…Although the mean age in the single-centre RCT (PALINT) from Slama et al [20] was slightly lower than 65 years (61.1 AE 9.8 years in the IG (n ¼ 60) receiving early integration of specialised PC, and 63.5 AE 10.4 years in the CG (n ¼ 66) receiving standard care), an important lesson can be learned from it. A total of n ¼ 36 (60%) from the IG and n ¼ 45 (68.2%) from the CG were !…”

Section: Key Pointsmentioning

confidence: 95%

Initiating early palliative care for older people with advanced cancer and its barriers

Bugaj

Oeljeklaus

Haun

2021

Current Opinion in Supportive &Amp; Palliative Care

View full text Add to dashboard Cite

Purpose of reviewEarly palliative care (EPC) is known to generally improve both health-related quality of life (QoL) and symptom intensity at small effect sizes. However, it is unclear whether EPC is effective in older people, a population that is notoriously unaccounted for. This review summarizes the recent evidence concerning the efficacy of EPC in older patients with advanced cancer and delineates existing barriers to accessing respective services. Recent findingsThe search for studies published in MEDLINE from January 2020 to September 2021 yielded six relevant records. Data from a recent feasibility trial and subgroups from larger randomised trials point to a somewhat lesser decline in QoL for patients undergoing EPC compared to those receiving treatment as usual. However, enrolling older patients in such trials remains a major challenge mostly due to them feeling too ill to participate.

show abstract

“…The relevance of highly specialized palliative care depends on the patient's needs and the standard of basic palliative care in the country or at the institution taking care of the patient [20]. Early integration can be feasible in resource-limiting countries [21] but to be effective, it is mandatory to have a multidisciplinary approach [22]. Some of these patients will also have rehabilitation needs [4].…”

Section: The Palliative Phasementioning

confidence: 99%

Teaching supportive care: what is the core curriculum?

Herrstedt

Molassiotis

2021

Current Opinion in Oncology

View full text Add to dashboard Cite

Purpose of reviewCancer treatment options have developed rapidly in the past years. Targeted-and immune therapy have resulted in additional supportive care needs. This review describes a teaching program in supportive care. Recent findingsSupportive care begins at the time of cancer diagnosis and continues until the patient has died or is cured and late toxicities and other survivorship issues have been properly addressed. Supportive care is divided into four phases. In the curative phase, competences regarding prevention and management of acute treatment and subacute treatment side effects are important. In the survivorship phase, competences related to late toxicity and chronic toxicity are warranted. In the palliative phase, focus will be on competences concerning cancer complications, and specific end-of-life competences are needed as well. Obviously some competences are needed in all phases, for example, communication skills. SummaryCompetences concerning symptoms and complications are summarized for each phase in table format. General competences are listed in the text body of the manuscript. Regular update and implementation is crucial. The future cancer population will consist of a higher number of older cancer patients and survivors. This should reflect curriculum updates as should the increasing possibilities for multigene sequencing enabling personal medicine (including supportive care) to a larger extent than today.

show abstract

Effects of Early and Systematic Integration of Specialist Palliative Care in Patients with Advanced Cancer: Randomized Controlled Trial PALINT

Cited by 15 publications

References 17 publications

Meta-Analysis of Effects of Early Palliative Care on Health-Related Outcomes Among Advanced Cancer Patients

Meta-Analysis of Effects of Early Palliative Care on Health-Related Outcomes Among Advanced Cancer Patients

Initiating early palliative care for older people with advanced cancer and its barriers

Teaching supportive care: what is the core curriculum?

Contact Info

Product

Resources

About