Effects of early-life cecal microbiota transplantation from divergently selected inbred chicken lines on growth, gut serotonin, and immune parameters in recipient chickens

Fu, Yuechi; Hu, Jiaying; Erasmus, Marisa A.; Johnson, Timothy A.; Cheng, Heng-Wei

doi:10.1016/j.psj.2022.101925

Cited by 12 publications

(20 citation statements)

References 90 publications

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“…Moreover, early intervention and controlled colonisation can also reduce the relative abundance of pathogens such as Enterococcus and Escherichia-Shigella and increase the concentration of short-chain fatty acids (SCFAs) like acetate, propionate, butyrate and isovalerate, thus improving gut health [ 38 ]. Controlled colonisation with a faecal transplant can also influence intestinal histomorphology [ 39 ] and growth rate [ 35 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Kayal

Stanley

Radovanović

et al. 2022

Animals

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The concept of designer microbiota in chicken is focused on early exposure of the hatchlings to pathogen-free microbiota inoculum, limiting the early access to harmful and pathogenic microorganisms, thus promoting colonisation of the gut with beneficial and natural poultry microbiota. In this study, we controlled colonisation of the intestine in broiler chickens in a large-scale industrial setting via at-hatch administration of a commercial product containing a highly diverse microbiota originating from the chicken caecum. The treatment significantly transformed the microbiota membership in the crop, proventriculus, jejunum and caecum and significantly altered the taxa abundance in the jejunum, jejunum mucosa, and caecum estimated using PERMANOVA and unweighted and weighted UniFrac distances, respectively. The treatment also improved the growth rate in chickens with no significant alteration in feed conversion ratio. A comparison of inoculum product microbiota structure revealed that the inoculum had the highest Shannon diversity index compared to all investigated gut sections, and the number of Observed Species second only to the caecal community. PCoA plots using weighted or unweighted UniFrac placed the inoculum samples together with the samples from the caecal origin.

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Section: Discussionmentioning

confidence: 99%

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Kayal

Stanley

Radovanović

et al. 2022

Animals

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“…CMT in early life (day-old chicks) may have great protective effects against stress-induced physiological and behavioral changes [ 219 , 220 ]. The current study showed that recipient chickens (6 3 -CMT compared to 7 2 -CMT) had different levels of aggression and related damaging behaviors, which was correlated with the degree of injurious behaviors of donors [ 123 ]. The early postnatal period is a vital window for birds as well as mammals to be colonized with the microbiome [ 213 ], whereby early-life CMT profoundly influences brain development and intestinal microbiota composition and diversity [ 221 ] with a long-lasting impact on gut–brain neural circuit development and its responses to stressful episodes [ 222 , 223 ].…”

Section: Cecal Microbiota Transplantation Social Stress and Injurious...mentioning

confidence: 99%

“…( D ) DESeq2 analysis of differentially abundant ASVs between line 6 3 and line 7 2 . Estimations of log2 fold change values for each ASV were computed and each point represents an ASV that was significantly different ( p ≤ 0.05) [ 106 ].…”

Section: Figurementioning

confidence: 99%

“…Values are least-squares means ± SEM, n = 7. a,b indicate significant differences ( P ≤ 0.05), A,B show trend differences (0.05 < P ≤ 0.10). Abbreviations: 5-HIAA, 5-hydroxuindoleacetic acid; 5-HT, serotonin; 6 3 -CMT, chickens with cecal bacterial solution of donor line 6 3 ; 7 2 -CMT, chickens with cecal bacterial solution of donor line 7 2 ; CTRL, control [ 106 ].…”

Section: Figurementioning

confidence: 99%

“…* indicates significant differences ( p ≤ 0.05), and # shows trend differences (0.05 < p ≤ 0.1). 6 3 -CMT, received cecal content solution from 6 3 donors; 7 2 -CMT, received cecal content solution from 7 2 donors; CTRL, received saline, control [ 123 ].…”

Section: Figurementioning

confidence: 99%

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The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Fu,

Hu,

Zhang

et al. 2024

Microorganisms

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Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota–gut–brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors. Restoration of the imbalanced gut microbial composition has become a novel treatment strategy for mental illnesses, such as depression, anxiety, bipolar disorder, schizophrenia, impulsivity, and compulsivity. A similar function of modulating gut microbial composition following stress challenge may be present in egg-laying chickens. The avian cecum, as a multi-purpose organ, has the greatest bacterial biodiversity (bacterial diversity, richness, and species composition) along the gastrointestinal tract, with vitally important functions in maintaining physiological and behavioral homeostasis, especially during the periods of stress. To identify the effects of the gut microbiome on injurious behaviors in egg-laying chickens, we have designed and tested the effects of transferring cecal contents from two divergently selected inbred chicken lines on social stress and stress-related injurious behaviors in recipient chicks of a commercial layer strain. This article reports the outcomes from a multi-year study on the modification of gut microbiota composition to reduce injurious behaviors in egg-laying chickens. An important discovery of this corpus of experiments is that injurious behaviors in chickens can be reduced or inhibited through modifying the gut microbiota composition and brain serotonergic activities via the gut–brain axis, without donor-recipient genetic effects.

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Effects of probiotic (Saccharomyces cerevisiae) and ascorbic acid on oxidative gene damage biomarker, heat shock protein 70 and interleukin 10 in broiler chickens exposed to heat stress

Sumanu¹,

Byaruhanga²,

Bosman³

et al. 2023

Animal Gene

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Effects of early-life cecal microbiota transplantation from divergently selected inbred chicken lines on growth, gut serotonin, and immune parameters in recipient chickens

Cited by 12 publications

References 90 publications

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

Controlled Intestinal Microbiota Colonisation in Broilers under the Industrial Production System

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Effects of probiotic (Saccharomyces cerevisiae) and ascorbic acid on oxidative gene damage biomarker, heat shock protein 70 and interleukin 10 in broiler chickens exposed to heat stress

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