Effects of early life stress on biochemical indicators of the dopaminergic system: a 3 level meta-analysis of rodent studies

Bonapersona, Valeria; Joëls, Marian; Sarabdjitsingh, R. Angela

doi:10.1101/372441

Cited by 11 publications

(14 citation statements)

References 147 publications

(172 reference statements)

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“…However, adolescent male and female rats with a single 24‐h maternal separation on post‐natal day 9 showed increased basal DA levels and a decrease of DOPAC/DA and HVA/DA ratios (Llorente et al, 2010). Indeed, a recent meta‐analysis of studies conducted in rodents with various early life stress experiences reports that there is strong support that such experiences alter DAergic mechanisms (Bonapersona et al, 2018).…”

Section: Potential Epigenetic Alterations In Addiction Neural Circuitrymentioning

confidence: 99%

Early life stress and the propensity to develop addictive behaviors

Walters

Kosten

2019

Intl J of Devlp Neuroscience

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There is a vast literature on effects of early life manipulations in rodents much of which is aimed at investigating the long‐term consequences related to emotion and cognition in adulthood. Less is known about how these manipulations affect responses reflective of alcohol (AUD) and substance (SUD) use disorders. The purpose of this paper is to review the literature of studies that employed early life manipulations and assessed behavioral responses to psychoactive substances, specifically alcohol, opiates, and stimulants, in rodents. While the findings with alcohol are more limited and mixed, studies with opiates and stimulants show strong support for the ability of these manipulations to enhance behavioral responsivity to these substances in line with epidemiological data. Some outcomes show sex differences. The mechanisms that influence these enduring changes may reflect epigenetic alterations. Several studies support a role for altered DNA methylation (and other epigenetic mechanisms) as biological responses to early environmental insults. The chemical changes induced by DNA methylation affect transcriptional activity of DNA and thus can have a long‐term impact on the individual's phenotype. Such effects are particularly robust when they occur during sensitive periods of brain development (e.g., first postnatal weeks in rodents). We review this emerging literature as it relates to the known neurobiology of AUDs and SUDs and suggest new avenues of research. Such findings will have implications for the treatment and prevention of AUDs and SUDs and could provide insight into factors that support resiliency.

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Section: Potential Epigenetic Alterations In Addiction Neural Circuitrymentioning

confidence: 99%

Early life stress and the propensity to develop addictive behaviors

Walters

Kosten

2019

Intl J of Devlp Neuroscience

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“…Mounting evidence suggests that dopaminergic neurotransmission can be influenced by psychosocial stress. Rodent studies have demonstrated that the striatal area is most vulnerable to the effects of early‐life stress that is associated with decreased levels of dopamine precursors and increased levels of dopamine metabolites (Bonapersona, Joëls, & Sarabdjitsingh, 2018). Greater dopamine release in response to psychosocial stress has also been associated with a history of childhood adversities (Pruessner, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness

Kotowicz

Frydecka

Gawęda

et al. 2019

Early Intervention Psych

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Aims Recent studies have provided evidence that interactions between variation in dopaminergic genes and stressful experiences might impact risk of psychosis. However, it remains unknown whether these interactions impact the development of subclinical symptoms, including psychotic‐like experiences (PLEs). In this study, we aimed to test the effects of interactions between variation in dopaminergic genes and traumatic life events (TLEs) on a severity of PLEs. Methods We assessed TLEs, cognitive biases, PLEs as well as the catechol‐O‐methyltransferase (COMT) rs4680 and the dopamine D2 receptor (DRD2) rs6277 gene polymorphisms in 445 university students at three urban areas. Results There was a significant effect of the interaction between the COMT rs4680 and a history of any type of TLEs on a severity of PLEs. Among the COMT rs4680 Met allele carriers, a severity of PLEs was higher in individuals with a history of any type of TLEs. Further stratification of the sample revealed that this effect appears only in the group of participants with a high level of cognitive biases. The DRD2 rs6277 C allele was independently associated with a higher level of PLEs. Conclusions Our results indicate that decreased dopamine catabolism related to the COMT gene polymorphism might increase psychosis proneness in individuals with a history of TLEs and high levels of cognitive biases. Variation in the DRD2 gene might exert independent effects on psychosis proneness. These findings imply that there are various levels of complexity in the models of interactions between genetic and environmental factors explaining the mechanisms underlying psychosis proneness.

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“…Other studies used a wide array of techniques to show the involvement of other dopamine receptors in mediating the social deficits observed after severe early‐life stress 58 . At a meta‐analytic level, however, the effects of early‐life adversity on the dopaminergic system appear limited, although significant for some parameters and areas 59 . It is important to note that none of the studies included in the meta‐analysis examined Drd4 as a potential target, highlighting the lack of preclinical evidence on the role of Drd4 expression in mediating effects of adverse rearing conditions.…”

Section: Discussionmentioning

confidence: 99%

Maternal care of heterozygous dopamine receptor D4 knockout mice: Differential susceptibility to early‐life rearing conditions

Knop

IJzendoorn

Bakermans‐Kranenburg

et al. 2020

Genes Brain and Behavior

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The differential susceptibility hypothesis proposes that individuals who are more susceptible to the negative effects of adverse rearing conditions may also benefit more from enriched environments. Evidence derived from human experiments suggests the lower efficacy dopamine receptor D4 (DRD4) 7‐repeat as a main factor in exhibiting these for better and for worse characteristics. However, human studies lack the genetic and environmental control offered by animal experiments, complicating assessment of causal relations. To study differential susceptibility in an animal model, we exposed Drd4+/− mice and control litter mates to a limited nesting/bedding (LN), standard nesting (SN) or communal nesting (CN) rearing environment from postnatal day (P) 2‐14. Puberty onset was examined from P24 to P36 and adult females were assessed on maternal care towards their own offspring. In both males and females, LN reared mice showed a delay in puberty onset that was partly mediated by a reduction in body weight at weaning, irrespective of Drd4 genotype. During adulthood, LN reared females exhibited characteristics of poor maternal care, whereas dams reared in CN environments showed lower rates of unpredictability towards their own offspring. Differential susceptibility was observed only for licking/grooming levels of female offspring towards their litter; LN reared Drd4+/− mice exhibited the lowest and CN reared Drd4+/− mice the highest levels of licking/grooming. These results indicate that both genetic and early‐environmental factors play an important role in shaping maternal care of the offspring for better and for worse.

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Effects of early life stress on biochemical indicators of the dopaminergic system: a 3 level meta-analysis of rodent studies

Cited by 11 publications

References 147 publications

Early life stress and the propensity to develop addictive behaviors

Early life stress and the propensity to develop addictive behaviors

Effects of traumatic life events, cognitive biases and variation in dopaminergic genes on psychosis proneness

Maternal care of heterozygous dopamine receptor D4 knockout mice: Differential susceptibility to early‐life rearing conditions

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