Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis

Möhr, Michael; Englisch, L; Roth, A.; Burchardi, H.; Zielmann, S.

doi:10.1007/s001340050471

Cited by 146 publications

(67 citation statements)

References 30 publications

(49 reference statements)

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“…For patients diagnosed with GBS, gamma globulin should be given as soon as possible, if there are no contraindications, otherwise plasma exchange can be used. [15] Despite the rare reports of GBS following head trauma or brain hemorrhage, we find that it is not as rare as we thought in clinical practice. GBS is not a common disease and it is easy to be ignored or misdiagnosed, especially following other severe situations like trauma and brain hemorrhage.…”

Section: Discussioncontrasting

confidence: 54%

Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Jia¹,

Tian²,

Wu³

et al. 2017

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Section: Discussioncontrasting

confidence: 54%

Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Jia¹,

Tian²,

Wu³

et al. 2017

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“…However, widespread acceptance of this treatment awaits further supportive data. 18,19 All of these measures were consistent with those of previous reports. 15,8,20 It should be noted, however, that none of these measure have been shown to have actual beneficial effects on muscle function in patients in the ICU.…”

Section: Discussionsupporting

confidence: 91%

Successful Management of Critical Illness Polyneuropathy and Myopathy in Renal Transplant Recipients

Gheith¹,

T²,

Halim³

et al. 2012

Exp Clin Transplant

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Critical illness polyneuropathy and myopathy commonly occur in patients with multiorgan failure and sepsis. Distal muscle weakness and loss of deep tendon reflexes are usually found, with sparing of the cranial nerve musculature. Many risk factors have been identified, specifically hypoxia, hypotension, hyperpyrexia, and age. Other independent risk factors include female sex, severity of illness, duration of organ dysfunction, renal failure and renal replacement therapy, hyperosmolality, parenteral nutrition, low serum albumin level, duration of intensive care unit stay, vasopressor and catecholamine support, and central neurologic failure. Hyperglycemia also has been identified as an independent risk factor, with important potential affect in terms of prevention. Herein, we report the development of critical illness polyneuropathy and myopathy in 7 of 22 renal transplant recipients who underwent successful ventilator weaning during treatment for bronchopneumonia. This is the first report of critical illness polyneuropathy and myopathy among renal transplant recipients. Clinical suspicion and electrophysiologic studies are tools for early diagnosis. Proper management, including correction of risk factors (especially diabetes) and long-term rehabilitation measures might be beneficial.

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“…Eleven out of the 29 (38%) 25,28,29,32,[36][37][38][39][40][41][42] observational studies were graded of low quality, 17 out of 29 (59%) 12,[14][15][16]20,24,26,27,30,[43][44][45][46][47][48][49][50] as medium and one (3%) 51 as high quality. There were four RCTs included; two studies were deemed of low risk, 22,23 one unclear risk 8 and one with high risk 31 of bias.…”

Section: Quality Of Included Studiesmentioning

confidence: 99%

The incidence of intensive care unit-acquired weakness syndromes: A systematic review

Appleton

Kinsella

Quasim

2014

Journal of the Intensive Care Society

157

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We conducted a literature review of the intensive care unit-acquired weakness syndromes (critical illness polyneuropathy, critical illness myopathy and critical illness neuromyopathy) with the primary objective of determining their incidence as a combined group. Studies were identified through MEDLINE, Embase, Cochrane Database and article reference list searches and were included if they evaluated the incidence of one or more of these conditions in an adult intensive care unit population. The incidence of an intensive care unit-acquired weakness syndrome in the included studies was 40% (1080/2686 patients, 95% confidence interval 38-42%). The intensive care unit populations included were heterogeneous though largely included patients receiving mechanical ventilation for seven or more days. Additional prespecified outcomes identified that the incidence of intensive care unit-acquired weakness varied with the diagnostic technique used, being lower with clinical (413/1276, 32%, 95% CI 30-35%) compared to electrophysiological techniques (749/1591, 47%, 95% CI 45-50%). Approximately a quarter of patients were not able to comply with clinical evaluation and this may be responsible for potential underreporting of this condition.

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Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis

Cited by 146 publications

References 30 publications

Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Two cases of Guillain-Barré syndrome after cerebral hemorrhage or head trauma

Successful Management of Critical Illness Polyneuropathy and Myopathy in Renal Transplant Recipients

The incidence of intensive care unit-acquired weakness syndromes: A systematic review

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