Effects of Egg Shell Membrane Hydrolysates on Anti-Inflammatory, Anti-Wrinkle, Anti-Microbial Activity and Moisture-Protection

Yoo, Jin Hee; Park, Kim Oon; Yoo, Young Je; Kim, Jong Keun; Yang, Hee-Jong; Shin, Young Jae

doi:10.5851/kosfa.2014.34.1.26

Cited by 34 publications

(31 citation statements)

References 30 publications

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“…Moreover, treatment with eggshells has previously shown a positive effect on skin parameters such as pigmentation and hydration. These effects seem to be mediated by an increase of collagen and HA levels, a reduction of matrix metalloproteinase activity, inhibition of collagenase and elastase, and inhibition of skin inflammation (Yoo et al 2014;Yoo et al, 2015). Although our results showed a tendency toward skin pigmentation reduction, the difference was not statistically significant.…”

Section: Discussioncontrasting

confidence: 78%

“…Eggshell membrane, an organic substance, is known to increase cellular activity, increase collagen production, slow skin aging, and reduce the detrimental effects of damage from UV light and inflammation (Candilish & Scougall,1969;Yoo et al, 2014;Yoo et al, 2015). The objective of this research was to study the effectiveness of Ovoderm, composed of egg membrane, on skin biophysical parameters, such as elasticity, pigmentation, and hydration, related to cutaneous aging.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies

Aguirre¹,

Gil-Quintana²,

Fenaux³

et al. 2017

Journal of Dietary Supplements

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Collagens and hyaluronic acid have long been used in pharmaceuticals and food supplements for the improvement of skin elasticity and hydration. These compounds provide the building blocks of the skin. Ovoderm is an oral supplement obtained from eggshells that contains naturally occurring collagen and glycosaminoglycans, such as hyaluronic acid. We evaluated the efficacy of Ovoderm on skin biophysical parameters related to cutaneous aging such as elasticity, hydration, and pigmentation. Two pilot studies were run to assess the effect of daily oral supplementation with 300 mg Ovoderm on skin parameters. The first consisted of a self-assessment questionnaire intended to perform an assessment on skin, hair, and nail health after 50 days of treatment. The second measured the effect of 5-week treatment on hydration by corneometry, on elasticity with the cutometer, and on pigmentation with the mexameter. In the pilot study 1, participants were predominantly satisfied with the effects obtained on general face (100% volunteers satisfied) and body (94% volunteers satisfied) skin condition and skin properties (100% volunteers satisfied with facial skin softness, 94% with facial skin hydration, and 89% with body skin hydration) and partly with effects on hair (67% volunteers satisfied) and nail (50% volunteers satisfied) condition. The study 2 revealed a statistically significant improvement in skin elasticity (12% increase, p =.0136), a tendency to reduce skin pigmentation (5% decrease), and no significant change in skin hydration. Our study reflects that oral supplementation with Ovoderm is efficacious to reduce the gradual loss of skin elasticity characteristic of aged skin, which helps to improve the appearance of the skin.

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Section: Discussioncontrasting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies

Aguirre¹,

Gil-Quintana²,

Fenaux³

et al. 2017

Journal of Dietary Supplements

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“…Elastin occupies only 2–4% of the dermis matrix and is known to have significant antiwrinkling properties along with collagen (Hong et al, ). Exposure of skin to UV light leads to an increased production of elastase and a concomitant decrease in skin elasticity (Yoo et al, ). This results in visible changes in the skin such as wrinkles, pigmentation, and increased thickness due to deformation and collapse (Kim et al, ; Yoo et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Exposure of skin to UV light leads to an increased production of elastase and a concomitant decrease in skin elasticity (Yoo et al, ). This results in visible changes in the skin such as wrinkles, pigmentation, and increased thickness due to deformation and collapse (Kim et al, ; Yoo et al, ). Among the control, HTP, and UF‐II, only HTP had an elastase inhibition effect of 22.22%, with elastase inhibitory activity equivalent to 1 mg/mL ascorbic acid.…”

Section: Resultsmentioning

confidence: 99%

Functionality of porcine skin hydrolysates produced by hydrothermal processing for liposomal delivery system

Choi

Min

2017

J Food Biochem

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Porcine skin proteins were hydrolyzed using hydrothermal processing (HTP) and fractionated by membrane ultrafiltration (UF) into peptides with different molecular weights (1-10 kDa). The porcine skin hydrolysates (PSHs) were analyzed for their antioxidant, antiaging, and skin permeation properties. Additionally, the PSHs were incorporated into liposomes with different charges to maintain and/or enhance their beneficial effect. The results showed that both HTP and UF-II (1-3 kDa) had significantly high antioxidant and antiaging effects and good skin permeability. Based on the results for PSH-loaded liposomes, the best carrier for incorporating PSHs was a positively charged liposome that had been prepared using positively charged lipid. PSH loaded with positively charged liposomes (PSH/LIP-P) had the following droplet properties: 71.11 nm, 0.208 PDI (polydispersity index), and 38.37 mV. PSH/LIP-P also had an incorporation efficiency of 70.72%, and the liposomes maintained their physical droplet stability during storage. Practical applicationsThe findings of this study highlighted porcine skin hydrolysates (PSH) produced by hydrothermal processing and membrane ultrafiltration with high antioxidant and antiaging effects and good skin permeability. PSH-loaded liposome capsules maintained a small size and high incorporation efficiency for PSH. The PSHs and PSH-loaded liposomes could be tested further for their in vivo functionality as nutraceutical or cosmeceutical ingredients. Hence, the finding could be useful information for developing potential commercial products in the food, cosmetics, and related industries. K E Y W O R D Santiaging effect, antioxidant effect, charged liposome, incorporation, porcine skin hydrolysate | I NTR OD U CTI ONThe functional food and cosmetic markets have grown rapidly over the last decade and are associated with consumer awareness of their roles in preventing disease and promoting health (Khiari, Ndagijimana, & Betti, 2014). Collagen has been widely used in food, cosmetics, pharmaceuticals, and medical applications due to its biological and functional properties (Li, Jia, & Yao, 2009;Zeng, Zahng, Adhikari, & Mujumdar, 2013). It is a fibrous insoluble protein that is mostly found in skin, cartilage, and connective tissues; it constitutes up to 30% of all body proteins and is the most abundant animal protein (Johnston, 1990). Recently, there has been interest in collagen with novel biologi- Each approach has advantages and limitations (McClements, 2014(McClements, , 2015. Liposomes are particularly suitable carriers for peptide delivery because they can encapsulate polar, nonpolar, and amphiphilic acids from protein hydrolysates (Mohan et al., 2016). In addition, liposomes can be easily produced from food grade materials; they can trap and release hydrophilic and hydrophobic ingredients and facilitate targeted actions (Jeon, Yoo, & Park, 2015).Therefore, the objective of this study was to produce porcine skin hydrolysates (PSHs) and investigate their antioxidant activity and phy...

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“…These findings are supported by other oral nutrition intervention studies where similar bioactive ingredients or sources were utilized, and similar results or the basis (the architecture) for the current results were found. [10][11][12]15,22,23 As the objective Canfield Visia-CR™ system was utilized for skin analysis, we also employed the subjective modified FACE-Q questionnaire as a means of capturing more robust information. The results on the subjective questionnaire in part support the objective improvements in overall skin appearance as observed with a reduction in crow's feet by week 4; however, the potential for placebo response cannot be discounted, as there were also aspects of the study that were not different between the groups.…”

Section: Con Clus Ionsmentioning

confidence: 99%

The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

Hewlings

2020

J of Cosmetic Dermatology

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Background Many over the counter and consumer packaged goods are promoted to enhance the appearance of hair, skin, and nails for the consumer. Nutrition is a major factor in affecting the health and appearance of hair, skin, and nails. In addition to how one eats, dietary supplementation may play a role in overall health and in the physical appearance. Aims It was the aim of this study to objectively and subjectively evaluate the impacts of a nutritional intervention as compared to placebo on the appearances of hair, skin, and nails in healthy middle‐aged adults. Methods Randomized, double‐blind placebo‐controlled study with 88 subjects randomized evenly to Study Product (BiovaBio™ 450 mg/d, n = 44) or Placebo (n = 44) for 12‐weeks. Outcome tests included TrichoScan HD (hair), Canfield Visia®‐CR (skin), modified FACE‐Q (skin), and anchored Likert Scales (nails). Results Oral hydrolyzed eggshell membrane ingestion was associated with a significant improvement in facial skin appearance in crow's feet in 4 weeks and skin tone in 8 weeks, with significant impact on hair thickness, reduction in hair breakage and improvement in hair growth at 4, 8, and 12 weeks. There were no observed subjective improvements for nails (appearance, strength or growth). Conclusions Oral supplementation of 450 mg/d hydrolyzed eggshell membrane for 12 weeks is associated with improvement in the appearance of facial skin and hair.

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Effects of Egg Shell Membrane Hydrolysates on Anti-Inflammatory, Anti-Wrinkle, Anti-Microbial Activity and Moisture-Protection

Cited by 34 publications

References 30 publications

Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies

Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies

Functionality of porcine skin hydrolysates produced by hydrothermal processing for liposomal delivery system

The effect of oral hydrolyzed eggshell membrane on the appearance of hair, skin, and nails in healthy middle‐aged adults: A randomized double‐blind placebo‐controlled clinical trial

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