Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats

Jung, Dal Lim; Lee, Seung-Deok; Choi, In Hwa; Na, Heung Sik; Hong, Seung-Ug

doi:10.1016/j.jdermsci.2013.11.015

Cited by 25 publications

(20 citation statements)

References 34 publications

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“…Although radical prostatectomy, chemotherapy, radiotherapy, high‐intensity focused ultrasound, and hormonal therapy surgery have been used for prostate cancer management, prostate cancer therapy is still limited because of chemo‐resistance and toxicity of anticancer agents. Thus, recently, many natural compounds such as curcumin (Cheng et al ., ), resveratrol (Alkhalaf, , ; Aluyen et al ., ; Whitlock et al ., ), capsaicin (Jung et al ., ), brazilin (Kim et al ., ), tanshinone I (Shin et al ., ), tanshinone IIa (Yun et al ., ), ursolic acid (Song et al ., ), coumestrol (Cho et al ., ), isothiocyanates (Gupta et al ., ), ginkgetin (You et al ., ), and auraptene (de Medina et al ., ) became attractive because of their efficacy and less toxicity.…”

Section: Introductionmentioning

confidence: 99%

Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells

et al. 2017

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Although auraptene, a prenyloxy coumarin from Citrus species, was known to have anti-oxidant, anti-bacterial, antiinflammatory, and anti-tumor activities, the underlying anti-tumor mechanism of auraptene in prostate cancers is not fully understood to date. Thus, in the present study, we have investigated the anti-tumor mechanism of auraptene mainly in PC3 and DU145 prostate cancer cells, because auraptene suppressed the viability of androgen-independent PC3 and DU145 prostate cancer cells better than androgen-sensitive LNCaP cells. Also, auraptene notably increased sub-G1 cell population and terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells as features of apoptosis in two prostate cancer cells compared with untreated control. Consistently, auraptene cleaved poly(ADP-ribose) polymerase, activated caspase-9 and caspase-3, suppressed the expression of anti-apoptotic proteins, including Bcl-2 and myeloid cell leukemia 1 (Mcl-1), and also activated pro-apoptotic protein Bax in both prostate cancer cells. However, Mcl-1 overexpression reversed the apoptotic effect of auraptene to increase sub-G1 population and induce caspase-9/3 in both prostate cancer cells. Taken together, the results support scientific evidences that auraptene induces apoptosis in PC3 and DU145 prostate cancer cells via Mcl-1-mediated activation of caspases as a potent chemopreventive agent for prostate cancer prevention and treatment. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells

et al. 2017

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“…We divided all skin lesions within 3 cm 2 of the shoulder into the inspection units (0.25 cm 2 ), inspected and scored the severity of each unit, and summed the scores per unit to yield the total score per rat individual. The scores for each unit were acquired according to the following criteria: 0, no symptoms; 1, erythema; 2, some bleeding or erosion; 3, bleeding or ulcerative lesions …”

Section: Methodsmentioning

confidence: 99%

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Jeong

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et al. 2019

J Biomed Mater Res

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Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with Rhus verniciflua extract (RVE)‐loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier‐transform infrared spectroscopy and an in vitro release assay. Rat pups were randomly divided into two groups: vehicle‐treated (VEH; n = 5) and capsaicin‐treated (n = 15). The latter were given capsaicin subcutaneously at 24 h after birth for AD induction and further divided into three groups (n = 5 per each): not treated (CAP), pullulan hydrogel‐applied (PH), and RVE@PH‐applied (RVE‐PH). The pullulan hydrogel and RVE@PH were topically applied on shoulder lesions for 14 days (from 42 to 56 days after birth). Their phenotypes were compared based on the dermatitis score, epidermal thickness, mast cell infiltration, and serum myeloperoxidase (MPO) activities. The PH group showed significant attenuation in all the aforementioned values compared to the CAP group, suggesting that pullulan hydrogel itself has therapeutic activity against AD. Notably, the attenuations were more potent in the RVE‐PH group than the PH group, indicating that the therapeutic efficacy against AD is augmented by the presence of RVE, a loaded pharmaceutic. Collectively, these results indicate that RVE@PH inhibits AD through exerting the dual roles, that is, the pullulan hydrogel‐mediated physical and RVE‐mediated pharmaceutical actions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2325–2334, 2019.

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“…Electroacupuncture is also useful to treat pruritus in AD. High-frequency electroacupuncture alleviated pruritus of AD-like lesions in rats induced by capsaicin injection through the release of dynorphin [21].…”

Section: New Therapeutic Targets For Admentioning

confidence: 96%

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Miyagaki

Sugaya

2015

Journal of Dermatological Science

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Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats

Cited by 25 publications

References 34 publications

Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells

Auraptene Induces Apoptosis via Myeloid Cell Leukemia 1-Mediated Activation of Caspases in PC3 and DU145 Prostate Cancer Cells

Topical film prepared with Rhus verniciflua extract‐loaded pullulan hydrogel for atopic dermatitis treatment

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

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