Effects of Electroacupuncture on Experimental Periodontitis in Rats

Lisboa, Mário Roberto Pontes; Gondim, Delane Viana; Ervolino, Edílson; Vale, Mariana Lima; Frota, Nicolly Parente Ribeiro; Nunes, Nara L.T.; Mariguela, Viviane Casagrande; Taba, Mário; Messora, Michel Reis; Furlaneto, Flávia Aparecida Chaves

doi:10.1902/jop.2015.140630

Cited by 22 publications

(22 citation statements)

References 39 publications

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“…Linear measurements on alveolar bone level (ABL) were performed at four different sites: buccal, lingual, interproximal and furcation [19]. For buccal, lingual and interproximal sites, the linear distances from cementoenamel junction (CEJ) to alveolar bone crest (ABC) were measured [20]. For the interproximal site, coronal dataset was analyzed using appropriated software (CT-Analyser ® , version 1.13.5.1+, Bruker, Kontich, Belgium) [19].…”

Section: Methodsmentioning

confidence: 99%

“…The images were analyzed using appropriate software (Diracon Bio Informatica Ltda., Vargem Grande do Sul, SP, Brazil). The ANB and the attachment loss (AL) were measured [18,20]. …”

Section: Methodsmentioning

confidence: 99%

“…A quantitative immunolabeling analysis of TRAP-positive cells and semi-quantitative immunolabeling analyses of IL-1β, CINC, IL-10 and TGF-β1 were performed in the entire furcation region at 400x magnification [20]. For semi-quantitative analyses, the following scores were determined: score 0–no immunolabeling (total absence of immunoreactivity in the area); score 1–low immunolabeling pattern (≈ ⅓ of the area presenting immunoreactivity); score 2–moderate immunolabeling pattern (≈ ⅔ of the area presenting immunoreactivity) and score 3–high immunolabeling pattern (almost the totality of the area presenting immunoreactivity) [19].…”

Section: Methodsmentioning

confidence: 99%

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Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Ricoldi¹,

Furlaneto²,

Oliveira³

et al. 2017

PLoS ONE

Self Cite

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Lactobacillus probiotics have been investigated in periodontitis. However, the effects of the genus Bifidobacterium on periodontitis are hardly known. This study evaluated the effects of the probiotic (PROB) Bifidobacterium animalis subsp. lactis (B. lactis) HN019 as an adjunct to scaling and root planing (SRP) in rats with experimental periodontitis (EP). At baseline, 32 rats were assigned to 4 groups: C (control), PROB, EP-SRP and EP-SRP-PROB. In groups EP-SRP and EP-SRP-PROB, the mandibular first molars of the animals received a ligature. At day 14, the ligatures were removed and SRP was performed. Animals of groups PROB and EP-SRP-PROB were orally administered with 10 mL/day of 109 colony forming units of B. lactis HN019 for 15 days, starting at day 14. Animals were euthanized at day 29. Histomorphometric, microtomographic and immunohistochemical analyses were performed. Microbiological effects of B. lactis on biofilm were also evaluated. Data were statistically analyzed (ANOVA, Tukey; Kruskal-Wallis, Dunn’s; Two-tailed t-test; p<0.05). Group EP-SRP-PROB presented reduced alveolar bone resorption and attachment loss when compared with Group EP-SRP (p<0.05). Group EP-SRP-PROB showed significantly fewer osteoclasts, increased expression of anti-inflammatory cytokines and reduced expression of proinflammatory cytokines compared with Group EP-SRP (p<0.05). B. lactis promoted a higher ratio between aerobic and anaerobic bacteria in biofilm samples (p<0.05). B. lactis HN019 may have a role in the treatment of EP in rats, as an adjunct to SRP.

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Section: Methodsmentioning

confidence: 99%

“…The images were analyzed using appropriate software (Diracon Bio Informatica Ltda., Vargem Grande do Sul, SP, Brazil). The ANB and the attachment loss (AL) were measured [18,20]. …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Ricoldi¹,

Furlaneto²,

Oliveira³

et al. 2017

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sterile disposable stainless steel acupuncture needles (0.25 mm × 30 mm; Dong Bang Acupuncture Inc., Chungnam, Korea) will be used. Acupuncture needles will be inserted bilaterally at the following acupuncture points: LI4, LI11, PC6, ST36, GB39 and LR3, and GV20 [12, 15, 18, 21]. If the GV20 is close to the surgical site, this acupoint may be excluded.…”

Section: Methodsmentioning

confidence: 99%

“…In rats with spastic cerebral palsy, serum TNF-α, IL-6, CRP, and nitric oxide synthase levels significantly decreased in the acupuncture group [17]. In experimental rats with periodontitis, electroacupuncture was seen to modulate the immune inflammatory response by decreasing the expression of IL-1β and matrix metalloproteinase-8, and increasing IL-6 messenger ribonucleic acid (mRNA) expression [18]. In addition, several studies have been conducted to evaluate the anti-inflammatory effects and regulation of immunity by acupuncture [19, 20].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and immune regulatory effects of acupuncture after craniotomy: study protocol for a parallel-group randomized controlled trial

Cho

Yang

Shin

et al. 2017

Trials

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BackgroundDespite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop infections severe enough to require a repeat operation despite antibiotic prophylaxis. Acupuncture has been used to treat inflammatory conditions, and many basic and clinical studies have provided evidence of its anti-inflammatory and immune regulatory effects. The aim of this study is to explore the effects of acupuncture on inflammation and immune function after craniotomy.MethodsThis trial will be a single-center, parallel-group clinical trial. Forty patients who underwent craniotomy for an unruptured aneurysm, facial spasm, or a brain tumor will be allocated to either the study or the control group. The study group will receive conventional management as well as acupuncture, electroacupuncture, and intradermal acupuncture, which will start within 48 h of the craniotomy. The patients will receive a total of six sessions within 8 days. The control group will only receive conventional management. The primary outcome measure will be the C-reactive protein levels, while the secondary outcomes will be the serum erythrocyte sedimentation rate and the tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels measured at four different time points: within 48 h prior to the craniotomy and on days 2, 4, and 7 after surgery. The presence of fever and infection, the use of additional antibiotics, the presence of infection, including pneumonia or urinary tract infection, and safety will also be investigated.DiscussionIn this trial, we will observe whether acupuncture has anti-inflammatory and immune regulatory effects after a craniotomy. If our study yields positive results and a placebo-controlled study also finds favorable results following our study, acupuncture could be recommended as an adjunctive therapy after a craniotomy.Trial registrationClinicalTrials.gov: NCT02761096. Registered on 27 April 2016. Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1712-7) contains supplementary material, which is available to authorized users.

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Zoledronate treatment exerts sex-independent effects on bone and dental physicochemical properties in mice jaw necrosis

Lima-Verde,

de Queiroz Rodrigues,

Vieira

et al. 2023

J Bone Miner Metab

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Effects of Electroacupuncture on Experimental Periodontitis in Rats

Abstract: It can be concluded that EA reduced periodontal tissue breakdown and the expression of some proinflammatory mediators and a proresorptive factor in EP in rats.

Cited by 22 publications

References 39 publications

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Anti-inflammatory and immune regulatory effects of acupuncture after craniotomy: study protocol for a parallel-group randomized controlled trial

Zoledronate treatment exerts sex-independent effects on bone and dental physicochemical properties in mice jaw necrosis

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