Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

Zhang, Li san; Chen, Zhong; Huang, Yu; Hu, Wei; Wei, Er Qing; Yanai, Kazuhiko

doi:10.1159/000071263

Cited by 46 publications

(32 citation statements)

References 20 publications

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“…Conversely, α-FMH, that diminishes histamine biosynthesis, increased seizure activity [144] ( Figure 6B). Similarly, HDC KO mice were more prone to seizures (Figure 6B) [145].…”

Section: Epilepsymentioning

confidence: 99%

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Sadek

Saad

Sadeq

et al. 2016

Behavioural Brain Research

135

129

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“…Conversely, α-FMH, that diminishes histamine biosynthesis, increased seizure activity [144] ( Figure 6B). Similarly, HDC KO mice were more prone to seizures (Figure 6B) [145].…”

Section: Epilepsymentioning

confidence: 99%

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Sadek

Saad

Sadeq

et al. 2016

Behavioural Brain Research

135

129

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“…In studies with non-epileptic rats, pyrilamine has been shown to augment the development of seizures in kindling models of convulsive seizures both after amygdala stimulation [6] and in rats with the pentylenetetrazole -induced kindling [7]. On the other hand, rats of the GAERS strain, another model of absence epilepsy, were partly resistant to amygdala kindling when compared to Wistar rats [8].…”

Section: Resultsmentioning

confidence: 99%

Dual effect of pyrilamine on absence seizures in WAG/Rij rats

et al. 2005

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IntroductionRats of WAG/Rij strain are widely used as a model of human absence epilepsy [1]. Recently, we reported that tissue histamine concentrations in a number of brain structures (e.g. in striatum, cortex, pons-medulla) were lower in WAG/Rij rats than in non-epileptic Wistar rats and that H 1 -receptors were denser in several regions of the epileptic rats (e.g. in brainstem nuclei) [2,3]. The purpose of the present study was to find out whether systemic administration of an H 1 -receptor antagonist had any effect on absence seizures in WAG/Rij rats. Materials and methodsTen male WAG/Rij rats (weight 220-350 g, age 5-7 months) were anaesthetized (chloral hydrate 4% solution, 10 ml/kg i.p; procaine 2% solution for soft tissue) and chronically implanted with epidural electrodes (stainless steel screws). The cortical electrodes were placed over the frontal and parieto-occipital regions of the neocortex with reference electrodes inserted over the cerebellum. Animals were allowed to recover from the surgery at least for 10 days. EEGs were recorded in freely moving animals. An index of epileptic activity, taken as a percentage of time occupied by the generalized spike-wave discharges [4] (spike-wave index, SWI), was calculated for each rat individually from the baseline EEGs recorded for 30-45 min. After i.p. pyrilamine injection (pyrilamine maleate, 20 mg/kg) EEG was monitored for 45-60 min. All experiments were performed according to institutional and national guidelines of animal care.Statistical analysis was performed by Kruskal-Wallis ANOVA and the Wilcoxon matched pairs test. Results are presented as the medians and ranges. Results and discussionNo general effect of pyrilamine on absence epileptic phenomena was found. Instead, both aggravation (post-injection SWI higher than basal SWI) and reduction (post-injection SWI lower than basal SWI) of the seizure activity were observed. Furthermore, statistical analysis revealed that Inflamm. res. 54, Supplement 1 (2005) S40-S41 increased or decreased epileptic activity after administration of pyrilamine corresponded to low and high basal level of absence seizures in individual rats, respectively (Fig. 1). Rats reacting with increment of absence seizures (N 1 = 5) had basal SWI of 1.5% (range 0.4%-2.4%), whereas the rats reacting with decrement of absence seizures (N 2 = 5) had basal SWI of 7.1% (range 5.4%-12%). The difference in the basal SWI between these two groups was statistically significant (N 1,2 = 5, p = 0.009 according to the Kruskal-Wallis ANOVA by ranks). The treatment effects were also significant (N 1,2 = 5, p = 0.04 for both groups, Wilcoxon matched pairs test). In the rats with low basal SWI (see above) the median SWI increased up to 3.5% (range: 2.4%-8.3%), in the rats with high basal SWI (see above) the median SWI decreased down to 0.6% (range 0%-4.9%).Pyrilamine in the dose of 20 mg/kg has been reported to induce electroencephalographic and behavioural convulsions in non-epileptic rats [5]. In our experiments with WAG/Rij rats no signs of behaviou...

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“…It is therefore likely that the reduced histamine plays an important role in the seizure susceptibility. We previously reported that α-fluoromethylhistidine, an inhibitor of HDC, accelerates seizure development induced by PTZ-kindling in rats [4] . The chronic kindled seizures markedly increased histamine levels in the cortex and hypothalamus in rats fed with the LH diet.…”

Section: Discussionmentioning

confidence: 97%

“…Since Churchill first described certain antihistaminics enhance epileptic extent [1] , a number of studies have indicated that brain histamine is involved in mechanisms regulating seizure susceptibility, and the anticonvulsant action of histamine has been well documented [2][3][4][5] . Histamine increases the threshold for amygdaloid kindling and pentylenetetrazol (PTZ)-induced seizures [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

Jin

Sakurai

Kiso

et al. 2005

Acta Pharmacologica Sinica

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Aim: To determine the role of dietary low histamine on the seizure development of pentylenetetrazol (PTZ)-induced kindling in rats. Methods: After 14 d of feeding on a low histamine diet (LH, containing 0.145 µmol/g of histamine), the rats were chemically kindled by repeated intraperitoneal injection of a subconvulsant dose of PTZ (35 mg/kg) once every 48 h, and seizure activity of kindling was recorded for 30 min. Histamine in brain samples was analyzed using a high performance liquid chromatography system with a fluorescence spectrofluorometer. Results: The LH diet induced an increase in seizure response (seizure susceptibility) to the first trial of PTZ, and resulted in facilitation of subsequent PTZ kindling process (seizure development). The histamine levels in the cortex, hippocampus, and hypothalamus of LH-treated rats decreased significantly and these changes correlated well with seizure behavior (r = 0.875, 0.651, and 0.796, respectively). In addition, chronic kindled seizures resulted in a significant increase of the histamine content in the cortex and hypothalamus in the LH-fed groups. Conclusion: These findings indicate that the histamine in daily food could influence the brain histaminergic function, and play an important role in regulating seizure susceptibility.

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Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats

Cited by 46 publications

References 20 publications

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

Dual effect of pyrilamine on absence seizures in WAG/Rij rats

Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

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