Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

Jin, Chun lei; Sakurai, Eiko; Kiso, Yoshinobu; Luo, Jun; Yanai, Kazuhiko; Chen, Zhong

doi:10.1111/j.1745-7254.2005.00097.x

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Our findings indicated a reduction of the interval between fever and seizure, as well as a significant increase in the seizure duration of the antihistamine group compared to the non-user group, which is consistent with the previous studies in this regard (16)(17)(18)(19)(20)(21)(22)(23). Furthermore, fever severity was lower in the antihistamine group compared to the non-user group, which is consistent with previous findings (22).…”

Section: Discussionsupporting

confidence: 92%

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Gorzin,

Hosseini,

Ghelichi-Ghojogh

et al. 2023

J Prev Epidemiol

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Introduction: Febrile seizures (FSs) are caused by the simultaneous consumption of first- and second-generation antihistamines, which prolong the process in some cases. Objectives: The present study aimed to evaluate the relationship between seizure susceptibility and type of antihistamines in patients with FS. Patients and Methods: This retrospective cohort study was conducted on 364 children with FS admitted to Taleghani Hospital in Gorgan, Iran in 2020. The subjects were selected via convenience sampling and divided into two groups of antihistamine and non-users based on their medical files. Data analysis was performed in SPSS16 using descriptive statistics and chi-square, independent t-test, Mann-Whitney U test, and relative risk. Results: The mean age of the patients was 22.77±14.91 months (6-60 months). 56.1% of the patients were male. Antihistamine was prescribed for 15.6% of the subjects, and the mean interval between fever onset and seizure was shorter in the antihistamine group (P=0.37). On the other hand, the mean seizure duration was significantly longer in the antihistamine group (P=0.049). The risk of a seizure lasting more than five minutes was 1.14 times higher in the first-generation antihistamine group compared to the second-generation group (P=0.078). Conclusion: According to the results, the patients with a history of antihistamine use during the febrile period experienced a significantly longer period of seizure, and a significant relationship was observed between the severity of seizures and antihistamine use. In addition, the mean seizure duration was longer in the first-generation antihistamine group. Therefore, the use of this class of drugs in this age range should be limited to the prescription of a specialist.

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Section: Discussionsupporting

confidence: 92%

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Gorzin,

Hosseini,

Ghelichi-Ghojogh

et al. 2023

J Prev Epidemiol

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“…Chromatographic conditions: Glutamate and GABA concentrations were determined by high-performance liquid chromatography (HPLC) combined with electrochemical detection using the technique developed in our laboratory (Jin et al, 2005). The system consisted of a model 582 pump, a model 540 autosampler, and a four-channel CoulArray electrochemical detector.…”

Section: Measurements Of Hippocampal Glutamate and Gaba Levelsmentioning

confidence: 99%

Improved learning and memory of contextual fear conditioning and hippocampal CA1 long‐term potentiation in histidine decarboxylase knock‐out mice

et al. 2007

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Some studies suggest that the histaminergic system plays an important role in learning and memory. However, the results seem to be controversial in many behavioral tasks. In the present study, we used HDC knockout (HDC-KO) mice to investigate the effects of long-term histamine deficiency on learning and memory in contextual fear conditioning. We found that HDC-KO mice exhibited improved contextual fear from 1 day after training and this lasted for at least 14 days when compared with the wild-type (WT) controls. Cued fear was also improved 2 days after training in HDC-KO mice. Moreover, injection of histamine (intracerebroventricularly, 10 microg/mouse) immediately after training reversed the improvement in contextual fear conditioning when tested 1 day after training. Electrophysiological data showed that hippocampal CA1 long-term potentiation (LTP) in HDC-KO mice was much greater than that in WT mice, and paired-pulse facilitation decreased 2 h after LTP induction in HDC-KO mice. In contrast, HDC-KO mice showed smaller LTP than did WT mice 1 day after training. Hippocampal glutamate levels significantly increased in HDC-KO mice 1 and 4 days after training. The results indicated that histamine deficiency may improve consolidation of contextual fear conditioning. This improvement may be due to the increased hippocampal CA1 LTP, and presynaptic glutamate release. The relationship between behavior and synaptic plasticity provides support for the involvement of activity-dependent LTP in learning and memory.

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“…Several studies related to the biphasic action of carnosine have been conducted. Jin et al showed that long-term treatment with a low histamine diet enhances seizure development induced by PTZ kindling, while this effect can be reversed by simultaneous treatment with a high carnosine diet (25).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Dose-Related Effects of Carnosine on Anxiety with Sympathetic Skin Response and T-maze

Dolu

Acer

Kara

2014

Acta Med. (Hradec Kralove, Czech Repub.)

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Carnosine is a dipeptide formed of the amino acids β-alanine and histidine. Only a limited number of studies have examined the effects of carnosine on sympathetic nerve activation and anxiety. The present study was undertaken to determine the dose-related effects of carnosine on anxiety in the elevated T-maze test (ETM) with electrodermal activity (EDA). Carnosine was injected in three groups of rats with doses of 10 (low dose), 100 (medium dose) and 1000 (high dose) mg/kg i.p. Physiological saline was injected in the sham group. The anxiety scores of the rats were measured with ETM 20 minutes after injection. Then, SCL was measured. The decreased number of entries into the open arm (NEOA), the percentage of time spent in the open arm (% TSOA) and higher EDA [shown by skin conductance level (SCL)] indicate higher anxiety. The NEOA and % TSOA were lower in the high-dose group than in the other groups. SCL was lower in the medium-dose carnosine group than in the high-dose carnosine and sham groups. SCL was higher in the high-dose group than in the medium-dose and sham groups. Our results suggest that high-dose carnosine produced anxiety-like effects as assessed in the SCL and ETM. Medium-dose carnosine acted as an anxiolytic. The anxiety-related responses of carnosine depend on its dose-related effect.

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Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats1

Cited by 10 publications

References 20 publications

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Association between seizure susceptibility with type and optimal dose of antihistamine in patients with a febrile seizure; A retrospective cohort study in Gorgan, Iran

Improved learning and memory of contextual fear conditioning and hippocampal CA1 long‐term potentiation in histidine decarboxylase knock‐out mice

Investigation of Dose-Related Effects of Carnosine on Anxiety with Sympathetic Skin Response and T-maze

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