A 30-year-old male farmer presented to our emergency department (ED) with complaints of pain and redness in the bite site approximately 1 h after being stung on his left foot by a scorpion while he was working on his farm in the night. The patient had no chronic diseases, medical drug use, or allergy in his medical history. He was discharged a few hours after his examination, treatment, and follow-up at the observation unit because all the symptoms were relieved after treatment and there were no abnormal values from the laboratory examinations. He was re-admitted to the ED with complaints of widespread body pain, fatigue, and mild shortness of breath approximately 6 h after his discharge. During his physical examination, he was conscious, cooperative, oriented, and also mildly agitated. His vital signs were blood pressure, 180/100 mmHg; heart rate, 130/min; tempera-ABSTRACT Introduction: Scorpion stings continue to be a current public health problem in tropical regions of the world. Local effects are usually seen, but fatal cardiovascular complications may occur, albeit rarely, from scorpion stings. The purpose of this case is to emphasize that rhabdomyolysis and myocarditis can occur in patients admitted to a hospital with a scorpion sting. Case Report: A 30-year-old male patient presented to our emergency department (ED) with complaints of pain and redness in the bite site after being stung by a scorpion. His blood pressure was 180/100 mmHg and heart rate was 130/ min. Electrocardiography (ECG) showed a sinus tachycardia. Laboratory tests revealed the following values: creatinine: 1.71 mg/dL, creatinin kinase (CK): 2129 U/L, creatinin kinase-myocardial band (CK-MB): 43.24 ng/mL, and troponin: 22.59 ng/mL. After catheterization of the bladder, dark brown urine was seen. There were no pathological findings in coronary angiography, but the left ventricular ejection fraction was detected as 45%. The clinically stable patient was discharged on the fifth day of hospitalization. There were no abnormal findings in the latest tests of laboratory parameters. Conclusion: Scorpion stings can cause death due to toxic effects on the cardiovascular system. Observations for possible complications from a scorpion sting, such as the possibility of myocarditis, should be kept in mind in patients admitted to the ED with complaints of a scorpion sting.

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Purpose: To examine brain diffusion characteristics in pediatric patients with attention deficit hyperactivity disorder (ADHD) using diffusion tensor imaging (DTI) and an atlas-based anatomical analysis of the whole brain and to investigate whether these images have unique characteristics that can support functional diagnoses. Materials and Methods: Seventeen children with ADHD and ten control subjects (all age-matched) underwent MRI scans. The Institutional Ethics Board approved this study. Morphometric analysis was performed using MriStudio software. The diffusion images were normalized using a linear transformation, followed by large deformation diffeomorphic metric mapping (LDDMM). For 189 parcellated brain regions, the volume, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured. Results: Children with ADHD were found to have increase in the body of lateral ventricle volumes compared to the control. Increased MD was found in the deep gray matter, amygdala, thalamus, substantia nigra, and also the cerebellum left and right side. Increased RD was found in the deep gray matter, caudate, thalamus, substantia nigra and hippocampus left and right side compared to the control. Significant elevated FA was found in the bilateral splenium of the corpus callosum in ADHD patients. Conclusion: Children with ADHD display abnormal diffusion characteristics and anatomical features compared to healthy controls. DTI can provide sensitive information on integrity of white matter (WM) and intra-WM structures in ADHD.

Carnosine is a dipeptide formed of the amino acids β-alanine and histidine. Only a limited number of studies have examined the effects of carnosine on sympathetic nerve activation and anxiety. The present study was undertaken to determine the dose-related effects of carnosine on anxiety in the elevated T-maze test (ETM) with electrodermal activity (EDA). Carnosine was injected in three groups of rats with doses of 10 (low dose), 100 (medium dose) and 1000 (high dose) mg/kg i.p. Physiological saline was injected in the sham group. The anxiety scores of the rats were measured with ETM 20 minutes after injection. Then, SCL was measured. The decreased number of entries into the open arm (NEOA), the percentage of time spent in the open arm (% TSOA) and higher EDA [shown by skin conductance level (SCL)] indicate higher anxiety. The NEOA and % TSOA were lower in the high-dose group than in the other groups. SCL was lower in the medium-dose carnosine group than in the high-dose carnosine and sham groups. SCL was higher in the high-dose group than in the medium-dose and sham groups. Our results suggest that high-dose carnosine produced anxiety-like effects as assessed in the SCL and ETM. Medium-dose carnosine acted as an anxiolytic. The anxiety-related responses of carnosine depend on its dose-related effect.

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