Effects of endorphins on motor behavior, striatal dopaminergic activity and dopaminergic receptors

Pérez-Cruet, Jorge; Volavka, Jan; Mallya, Ashok; Baig, Sadat

doi:10.1007/978-1-349-04015-5_27

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…Since all drives activate the command system SEEKING ( Kirsch, 2019 ; Kirsch and Buchholz, 2020 ) and because SEEKING runs on dopamine ( Panksepp and Biven, 2012 ; Johnson et al, 2022 ), β-endorphin must be able to render the activity of SEEKING (probably by decreasing the dopamine activity) when β-endorphin acts as a general, late down-streaming metabolite of all drives. In fact, β-endorphin renders (striatal and hypothalamic) dopaminergic activity ( Peres-Cruet et al, 1979 ; van Loon et al, 1980 ) via increasing dopamine re-uptake by dopaminergic nerve terminals ( George and van Loon, 1982 ). In principle, the essential drives would be able to neutralize the claim of the “death drive” if the latter would also release β-endorphin as a late down-streaming product.…”

Section: Rationalementioning

confidence: 99%

“Death drive” scientifically reconsidered: Not a drive but a collection of trauma-induced auto-addictive diseases

Kirsch

Dimitrijević²,

Buchholz³

2022

Front. Psychol.

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Over the last 102 years, a lot of discussion was being held about the psychoanalytic conception of the “death drive,” but still with inconclusive results. In this paper, we start with a brief review of Freud’s conception, followed by a comprised overview of its subsequent support or criticisms. The core of our argument is a systematic review of current biochemical research about two proposed manifestations of the “death drive,” which could hopefully move the discussion to the realm of science. It was already established that drive satisfaction leads to the secretion of beta-endorphins, and research evidence also shows that the same biochemical mechanisms get activated in the case of masochism and the gambling disorder but only if they are preceded by chronic frustration of the essential drives. We conclude that the actual situation is more complex than Freud hypothesized, and that a fundamental revision of the psychoanalytic drive theory is necessary.

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Section: Rationalementioning

confidence: 99%

“Death drive” scientifically reconsidered: Not a drive but a collection of trauma-induced auto-addictive diseases

Kirsch

Dimitrijević²,

Buchholz³

2022

Front. Psychol.

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“…Pharmacological effects of opioids and opiate antagonists in animals and humans. High doses of /3-endorphin cause muscular rigidity and immobility, which can be blocked by naloxone (Bloom et al 1976;Perez-Cruet et al 1979), suggesting a similarity between this behavior and catatonic schizophrenia. Naturally any animal model of mental illness must be regarded as highly tentative.…”

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confidence: 97%

Narcotic Antagonists in Schizophrenia: A Methodological Review

Mueser

Dysken

1983

Schizophrenia Bulletin

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Studies investigating the efficacy of the opiate antagonists naloxone and naltrexone in the treatment of schizophrenia are reviewed. Naloxone tended to ameliorate psychotic symptoms of noncatatonic schizophrenic patients when a dose of at least 4 mg was administered, although some of the high-dose studies produced conflicting results. Possible factors relating to the nonresponder issue are discussed, including concomitant neuroleptic medication, interindividual dose sensitivity, and subject selection criteria and target symptoms. Recommendations are made for more intensive study of single cases and experimental designs aimed at delineating the interactions between naloxone and neuroleptics, and assessing the need for stringent subject selection criteria. Naloxone also enhanced movement in stuporous and catatonic schizophrenics. Naltrexone, on the other hand, had more negative than positive effects on schizophrenic patients, possibly because of opiate agonist properties.

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β-Endorphin

Gerner¹

1980

Arch Gen Psychiatry

142

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Effects of endorphins on motor behavior, striatal dopaminergic activity and dopaminergic receptors

Cited by 6 publications

References 13 publications

“Death drive” scientifically reconsidered: Not a drive but a collection of trauma-induced auto-addictive diseases

“Death drive” scientifically reconsidered: Not a drive but a collection of trauma-induced auto-addictive diseases

Narcotic Antagonists in Schizophrenia: A Methodological Review

β-Endorphin

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