Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-α and Interferon-γ in Sedentary Men

Jahromi, Abdolreza Sotoodeh; Zar, Abdossaleh; Ahmadi, Fatemeh; Krustrup, Peter; Ebrahim, Khosro; Hovanloo, Fariborz; Amani, Davar

doi:10.4110/in.2014.14.5.255

Cited by 25 publications

(13 citation statements)

References 21 publications

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“…The reaction of cytokines to training was multiplex and associated with the intensity of the training, exercise situations, site of cytokine evaluation (e.g. tissue, plasma or urine), and sensibility of measurement process (22). This study wasn't consistent with the current study and this difference can be due to differences in subjects, measurement methods, and differences in exercise protocols.…”

Section: Discussioncontrasting

confidence: 73%

Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats

Mousavi

Asad

Barzegari

et al. 2018

Hormozgan medical journal

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Background: Aging impairs function of the heart and is associated with mechanical remodeling. This process involves accumulation of collagen and dysfunction in the regulation of active matrix metalloproteinase. On the other hand, exercise training improves cardiac function and regulates the increase of pro-inflammatory molecules, such as interferon gamma, yet the impact of exercise training on aging has not yet been defined. Objectives: This study examined the effect of continuous endurance training on mRNA expression of interferon gamma (IFN-γ) and matrix metalloproteinase-9 (MMP-9) in male elder rats. Methods: For this purpose, 14 Wistar male rats with age of 24 to 26 months and an average weight of 380 ± 20 g were randomly divided to two groups, including training (n = 7) and control (n = 7). Training groups performed continuous endurance training for six weeks. Matrix metalloproteinase-9 mRNA and interferon (IFN)-γ mRNA expression in heart tissue were measured by real-time polymerase chain reaction. To analyze of the data, the independent t-test was used at a significance level of P < 0.05. Results: The findings of this statistical analysis showed that six weeks of continuous endurance training had a significant effect on MMP-9 mRNA expression (P = 0.001). Also, this training protocol did not have a significant effect on expression of IFN-γ gene (P = 0.628). Conclusions: Continuous endurance training attenuated aging-induced cardiac inflammation of rats. There are numerous questions that remain to be answered to complete the understanding of the moderator effects of exercise on MMP-9 and IFN-γ, as a muscle conformity or indicate an inflammatory condition.

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Section: Discussioncontrasting

confidence: 73%

Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats

Mousavi

Asad

Barzegari

et al. 2018

Hormozgan medical journal

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“…The heart rates of all the participants were recorded for the maximal heart rate calculation using Karvonen method ( 14 ) as follows: HR target=% Intensity (HR max−HR rest)+HR rest …”

Section: Methodsmentioning

confidence: 99%

Cytokine Pattern is Affected by Training Intensity in Women Futsal Players

et al. 2016

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To find the relation between exercise and cytokines, we examined the effect of the training intensity on the levels of cytokines, including interferon-gamma (IFN-γ), interlukine-4 (IL-4) and interlukine-4/interferon-gamma ratio (IL-4/IFN-γ ratio) in female Futsal players. Twelve well-trained female college Futsal players aged 19~22 participated in this study. The athletes completed 30-min of running at 60~65% maximal heart rate [moderate-intensity exercise], and 30-min of running at 75~80% maximal heart rate [high-intensity exercise]. peripheral blood samples were collected 24 h before and 24 h and 48 h after each of the exercise bouts. finding showed that The 30-min bout of moderate-intensity exercise induced a significant increase in IFN-γ (p=0.01) and significant decreases in IL-4 (p=0.001) and IL-4/IFN-γ ratio (p=0.003). And also, 30-min of running at 75~80% maximal heart rate induced increase in IFN-γ (p=0.07) and decreased in IL-4 (p=0.01) and IL-4/IFN-γ ratio (p=0.06) that these changes not significantly. In summary, exercise intensity can effect on the magnitude of changes in cytokines. It seems that moderate intensity exercise enhances cytokine pattern in female college Futsal players.

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“…The fact that TNF-␣ upregulation correlated with the upregulation of ANF, collagen type 1␣ 2 , and the increase in LVESV suggests that inflammation is an important signaling mechanism that contributes to LV remodeling processes. Anti-inflammatory effects of exercise per se have been already widely discussed (28,60). In the context of myocardial injury, it has been previously reported that endurance training reduces TNF-␣ levels in plasma of patients with heart failure (1) and in the soleus muscle of infarcted rats (3).…”

Section: H355 Exercise Limits Post-mi Scar Thinningmentioning

confidence: 99%

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

Puhl

Müller

Wagner

et al. 2015

American Journal of Physiology-Heart and Circulatory Physiology

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Although exercise mediates beneficial effects in patients after myocardial infarction (MI), the underlying mechanisms as well as the question of whether an early start of exercise after MI is safe or even beneficial are incompletely resolved. The present study analyzed the effects of exercise before and reinitiated early after MI on cardiac remodeling and function. Male C57BL/6N mice were housed sedentary or with the opportunity to voluntarily exercise for 6 wk before MI induction (ligation of the left anterior descending coronary artery) or sham operation. After a 5-day exercise-free phase after MI, mice were allowed to reexercise for another 4 wk. Exercise before MI induced adaptive hypertrophy with moderate increases in heart weight, cardiomyocyte diameter, and left ventricular (LV) end-diastolic volume, but without fibrosis. In sedentary mice, MI induced eccentric LV hypertrophy with massive fibrosis but maintained systolic LV function. While in exercised mice gross LV end-diastolic volumes and systolic function did not differ from sedentary mice after MI, LV collagen content and thinning of the infarcted area were reduced. This was associated with ameliorated activation of inflammation, mediated by TNF-␣, IL-1␤, and IL-6, as well as reduced activation of matrix metalloproteinase 9. In contrast, no differences in the activation patterns of various MAPKs or adenosine receptor expressions were observed 5 wk after MI in sedentary or exercised mice. In conclusion, continuous exercise training before and with an early reonset after MI ameliorates adverse LV remodeling by attenuating inflammation, fibrosis, and scar thinning. Therefore, an early reonset of exercise after MI can be encouraged. exercise; remodeling; scar thinning; magnetic resonance imaging; fibrosis; myocardial infarction NEW & NOTEWORTHY Our data provide new insights into the exercise-mediated cardioprotection by implying that an early reinitiation of exercise after myocardial infarction attenuates left ventricular fibrosis and scar thinning, presumably by attenuating the coordinated proinflammatory response involving TNF-␣, IL-6, and IL-1␤. These findings could translate into clinical benefits in patients.CORONARY ARTERY DISEASE is the single most frequent cause of death worldwide. In Europe, every sixth man and every seventh woman will die of myocardial infarction (MI) (71). Those patients who survive MI frequently develop systolic heart failure due to the infarct-induced loss of functional myocardium per se and remodeling of the remainder of the left ventricular (LV) myocardium, which is frequently associated with thinning of the LV wall in the area of MI and its border zone, LV dilation, and systolic dysfunction. These parameters of myocardial remodeling are important prognostic markers for the long-term outcome of these patients. For instance, regional wall thinning is associated with postinfarction ventricular arrhythmia (36) and adverse outcome in patients undergoing coronary artery bypass surgery (87).Scar formation occurs secondary to isc...

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Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-α and Interferon-γ in Sedentary Men

Cited by 25 publications

References 21 publications

Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats

Effect of Continuous Endurance Training on mRNA Expression of Interferon Gamma and Matrix Metalloproteinase-9 in Male Elder Rats

Cytokine Pattern is Affected by Training Intensity in Women Futsal Players

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice

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