Effects of enhanced viscosity on canine gastric and intestinal motility

Xu, Xiaohong; Brining, Douglas; Rafiq, Asad; Hayes, James; Chen, J D Z

doi:10.1111/j.1440-1746.2005.03604.x

Cited by 24 publications

(17 citation statements)

References 24 publications

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“…It is well known that IDFs such as cellulose will increase in volume by absorbing water and will stimulate intestinal motility by distending the intestinal wall, whereas SDFs such as pectin are highly water soluble and make viscous solutions (gel) that facilitate the smooth transit of food from the upper to the lower intestine [20,21]. Recently, we reported that IDFs play an important role in the formation of lesions in the small intestine induced by IND in cats.…”

Section: Discussionmentioning

confidence: 98%

“…In a previous report [19], we suggested that indigestible solid components of food, such as IDFs, together with NSAIDinduced intestinal hypermotility may cause damage to the surface of the intestinal mucosa when mucus is decreased. The effects of SDFs on GI motility have been studied in relation to glucose absorption, since it is well known that SDFs often cause glucose flattering [21,23]. There have been conflicting reports on the effect of SDFs on GI motility; i.e., SDFs have been shown in some studies to stimulate GI motility in humans [25], dogs [20], and pigs [26], whereas other studies have shown no effect on motility in humans [27] and dogs [21].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of SDFs on GI motility have been studied in relation to glucose absorption, since it is well known that SDFs often cause glucose flattering [21,23]. There have been conflicting reports on the effect of SDFs on GI motility; i.e., SDFs have been shown in some studies to stimulate GI motility in humans [25], dogs [20], and pigs [26], whereas other studies have shown no effect on motility in humans [27] and dogs [21]. We examined the effect of pectin and misoprostol on ileal hypermotility caused by IND.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

et al. 2009

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

et al. 2009

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“…Another investigation by Garcia-Casado et al used spike potential recordings made using surface electrodes to investigate and monitor intestinal mechanical activity in dogs (Garcia-Casado et al 2005). Finally, Xu et al studied the effects of enhanced viscosity on canine gastric and intestinal motility from invasive ECA and ERA recordings (Xu et al 2005).…”

Section: Motivation and Purposementioning

confidence: 99%

Magnetogastrographic detection of gastric electrical response activity in humans

2006

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The detection and characterization of gastric electrical activity has important clinical applications, including the early diagnosis of gastric diseases in humans. In mammals, this phenomenon has two important features: an electrical control activity (ECA) that manifests itself as an electric slow wave (with a frequency of 3 cycles per minute in humans) and an electrical response activity (ERA) that is characterized by spiking potentials during the plateau phase of the ECA. Whereas the ECA has been recorded in humans both invasively and non-invasively (magnetogastrography-MGG), the ERA has never been detected non-invasively in humans before. In this paper, we report on our progress towards the non-invasive detection of ERA from the human stomach using a procedure that involves the application of principal component analysis to MGG recordings, which were acquired in our case from ten normal human patients using a Superconducting QUantum Interference Device (SQUID) magnetometer. Both pre-and post-prandial recordings were acquired for each patient and 20 min of recordings (10 min of pre-prandial and 10 min of post-prandial data) were analysed for each patient. The mean percentage of ECA slow waves that were found to exhibit spikes of suspected ERA origin was 41% and 61% for pre-and post-prandial recordings, respectively, implying a 47% ERA increase post-prandially (P < 0.0001 at a 95% confidence level). The detection of ERA in humans is highly encouraging and points to the possible use of non-invasive ERA recordings as a valuable tool for the study of human gastric disorders.

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“…Taking into account that alloxan is an agent that selectively destroys the β-cells (Balogh et al, 2008) and decreases the endogenous insulin secretion (Yamamoto et al, 1981), our findings indicate that G. latifolium through mechanism of delayed GE may have resulted in gradual release of nutrients for absorption to match the lower levels of insulin and prevent the accumulation of excess glucose. Gastric emptying is one of the factors that affect the rate and completeness of intestinal nutrient absorption (Xu et al, 2005). "Therefore, it seems reasonable to speculate that G. latifolium attenuates blood glucose excursions partly through delayed GE, thus delaying the transfer of glucose from the stomach to the small intestine.…”

Section: Discussionmentioning

confidence: 99%

<i>Gongronema Latifolium</i> delays gastric emptying of semi-solid meals in diabetic dogs

Ogbu¹,

Agwu²,

Asuzu³

2013

Afr. J. Trad. Compl. Alt. Med.

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The aim of the study was to investigate sonographically the effect of Gongronema latifolium on gastric emptying of semi-solid meals in diabetic dogs. Twenty-five alloxan-induced diabetic dogs were randomly allotted into five groups of five dogs each in a randomised placebo-controlled study. These are placebo, prokinetic dose, low dose, moderate dose and high dose groups. The placebo group served as the control. The low, moderate and high dose groups ingested methanolic leaf extract of G. latifolium at 100 mg/kg, 250 mg/kg, 500 mg/kg respectively, while the prokinetic group ingested 0.5 mg/kg of metoclopramide. After a 12-hour fast, each group ingested its treatment capsules 30 minutes before the administration of test meal. Measurements of gastric emptying and blood glucose levels were obtained from each dog 30 minutes before and immediately after the ingestion of a test meal, every 15 minutes for another 4 hours and then every 30 minutes for further 2 hours. Gastric emptying of the moderate and high dose groups were 227.8 ± 9.9 min and 261.3 ± 19.3 min respectively and significantly (p < 0.0001) slower than the placebo control group of 143.0 ±17.8 min. The gastric emptying of the low dose group (169.8 ± 3.8) and control group did not differ significantly (p > 0.05). A strong inverse relationship between gastric emptying and the incremental blood glucose levels was noted in the diabetic dogs after the ingestion of Gongronema latifolium (r = -0.90; p < 0.0001). Gonogronema latifolium delayed gastric emptying in diabetic dogs.

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Effects of enhanced viscosity on canine gastric and intestinal motility

Abstract: It was concluded that enhanced viscosity delays gastric emptying, increases postprandial intestinal but not gastric motility, and has no effects on gastric or intestinal slow waves.

Cited by 24 publications

References 24 publications

Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

Magnetogastrographic detection of gastric electrical response activity in humans

<i>Gongronema Latifolium</i> delays gastric emptying of semi-solid meals in diabetic dogs

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