Effects of (−)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue

Tanaka, Masaaki; Baba, Yoshitake; Kataoka, Yosky; Kinbara, Noriaki; Sagesaka, Yuko M.; Kakuda, Takami; Watanabe, Yasuyoshi

doi:10.1016/j.nut.2008.03.001

Cited by 46 publications

(37 citation statements)

References 28 publications

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“…Fatigue can be classified as physical and mental fatigue. Physical fatigue is thought to be accompanied by deterioration in exercise performance (Tanaka et al 2008). The mechanisms of physical fatigue are complicated, metabolic dysregulation, and free radicals damage can result in fatigue (McArdle et al 2005;Zhang et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

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Objective: The present study investigates the effects of macamides on endurance capacity and antifatigue property in prolonged swimming mice. Materials and methods: The Balb/c mice were divided into seven groups: a control group, low-dose groups of N-benzyllinoleamide, N-benzyloleamide, and N-benzylpalmitamide, high-dose groups of these macamides. The macamides groups received the commercial products (12 and 40 mg/kg, ig), while the control group received vehicle for 21 d. On the 14th day, the mice were given the weightloaded swimming test. On the 21st day, the mice were sacrificed immediately after 90 min swimming, and some biochemical parameters were measured. Results and discussion: Compared with the control group, exhaustive swimming time was significantly prolonged in high-dose group of N-benzyloleamide (p50.05); the levels of lactic acid (LD), blood ammonia (BA), and lactate dehydrogenase (LDH) were significantly decreased (p50.05), whereas the levels of liver glycogen (LG) and non-esterified fatty acid (NEFA) were significantly increased (p50.05) in high-dose group of N-benzyloleamide. The malondialdehyde (MDA) contents in the brain, muscle, and liver were significantly decreased (p50.05), whereas superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in the brain, muscle, and liver were significantly increased in high-dose group of N-benzyloleamide (p50.05). Conclusion:The results indicate that N-benzyloleamide has pharmaceutical property against exercise-induced fatigue, and this effect can be explained by the modulated energy metabolism and improved antioxidant status.

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Section: Introductionmentioning

confidence: 99%

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Yang

Jin

et al. 2015

Pharmaceutical Biology

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“…Fatigue Model Induced by Water-Immersion Fatigue was induced by housing the rats under water-immersed condition according to the methods of Tanaka et al 3,6) Rats were housed individually for 5 d in a plastic cage (27×44×20 cm; Toyo-riko Co., Ltd., Tokyo, Japan) filled with 23°C water to a height of 1.5 cm. The water was changed every day.…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, Watanabe and co-workers designed an animal model of combined fatigue by housing rats in a cage filled with water for several days. [3][4][5][6][7] Under such conditions, rats cannot rest or sleep, and they are thereby fatigued both physically and mentally. Development of fatigue was confirmed by a weight-loaded forced swimming test after the rats were housed for 5 d under water-immersed conditions.…”

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confidence: 99%

“…Development of fatigue was confirmed by a weight-loaded forced swimming test after the rats were housed for 5 d under water-immersed conditions. 3,6,7) It has been suggested that decreased glucose uptake into the brain, insufficient serotonin and dopamine turnover in the brain, and altered expression of some peptidases in the pituitary gland are implicated in the causes of such combined fatigue. 3,4) However, the onset mechanisms of combined fatigue are not completely elucidated.…”

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confidence: 99%

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Effects of Memantine, an <i>N</i>-Methyl-<small>D</small>-aspartate Receptor Antagonist, on Fatigue and Neuronal Brain Damage in a Rat Model of Combined (Physical and Mental) Fatigue

Morimoto¹,

Zhang²,

Adachi³

2012

Biological & Pharmaceutical Bulletin

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Most of the fatigue in everyday life is a combination of physical and mental fatigue. Recently, an animal model of combined fatigue was designed by housing rats in a cage filled with water. We have previously hypothesized that mental fatigue is caused partly by neuronal brain damage through the activation of N-methyl-D-aspartate (NMDA) receptors by quinolinic acid (QUIN), a metabolite of tryptophan (TRP). Therefore, we investigated whether the same mechanism also participates in combined fatigue. Rats were housed for 5 d under water-immersed conditions, and the extent of fatigue was evaluated by a weight-loaded forced swimming test. The swimming time of the water-immersed group was shorter than that of the control group, indicating that rats were fatigued by water-immersion. However, unexpectedly, the blood and brain levels of QUIN in the water-immersed group were lower than those of the control group. QUIN levels in both the blood and brains of a food-restricted nonimmersed group, where body weight was matched with the water-immersed group, were also decreased, suggesting that decreased QUIN in the water-immersed group originated from a reduced intake of TRP-containing food. On the other hand, hippocampal neuronal damage was shown in the water-immersed group, similar to that seen in other fatigue models where QUIN increased. Memantine, an NMDA receptor antagonist, inhibited not only the reduction in swimming times but also the neuronal damage induced by water-immersion. These results suggest that neuronal brain damage by an endogenous NMDA receptor agonist other than QUIN participates in combined fatigue by water immersion.

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“…Exercise fatigue is a decline in physical function or exercise capacity caused by a certain amount of movement. Chronic fatigue is not mitigated by rest accompanied by sore throat, headache, muscle and joint pain, and memory loss, and it may occur repeatedly and last for more than six mon (Ream and Richardson 1997;Chaudhuri and Behan 2004;Tanaka et al 2008). Considering fatigue is related to many research methods, the mechanism of fatigue is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and anti-exercise-fatigue effect of highly denatured soybean meal hydrolysate prepared using neutrase

2013

J Food Sci Technol

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Highly denatured soybean meal is a by-product of soybean oil extraction obtained through high-temperature desolventization. High-temperature treatment can result in soybean protein denaturation. Compare with ordinary soybean meal, the protein structure of highly denatured soybean meal has changed. Highly denatured soybean meal was pretreated with thermal treatment or ultrasonication, and then hydrolyzed with neutrase. The ultrasonicated hydrolysate exhibited better antioxidant activity than the thermally treated hydrolysate. The ultrasonication increased 1,1-diphenyl-2-pycryl hydrazyl (DPPH) radical scavenging activity by 8.31 % and reduction capacity by 10.19 %. The highly denatured soybean meal hydrolysate ultrasonicated at 400 W exhibited the highest antioxidant activity. The DPPH radical scavenging activity was 56.22 % and reduction capacity was 0.717. The ultrasonicated hydrolysate at 400 W was fractionated using ultrafiltration into three fractions: I (>10 kDa), II (5 kDa to 10 kDa), and III (<5 kDa). The in vitro antioxidant activity and others in vivo anti-exercise-fatigue effect of the three fractions (I, II, and III) were determined. Fraction III exhibited the highest DPPH radical scavenging activity and reduction capacity, improved the hemoglobin and hepatic glycogen content and reduced blood urea nitrogen and blood lactic acid. Fraction III improved the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and reduced the malonaldehyde (MDA) content in mouse livers. Therefore, the highly denatured soybean meal hydrolysate has an anti-oxidative effect and it significantly alleviates exercisefatigue in mice. Amino acids of hydrolysate were determined.Results showed that the antioxidant activity and anti-exercisefatigue effect were related to the amino acid compositions.

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Effects of (−)-epigallocatechin gallate in liver of an animal model of combined (physical and mental) fatigue

Cited by 46 publications

References 28 publications

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Effects of macamides on endurance capacity and anti-fatigue property in prolonged swimming mice

Effects of Memantine, an <i>N</i>-Methyl-<small>D</small>-aspartate Receptor Antagonist, on Fatigue and Neuronal Brain Damage in a Rat Model of Combined (Physical and Mental) Fatigue

Antioxidant activity and anti-exercise-fatigue effect of highly denatured soybean meal hydrolysate prepared using neutrase

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