Effects of eplerenone on P-wave signal-averaged electrocardiogram in hypertensive patients with coronary artery disease

Eplerenone might affect atrial fibrosis in patients with hypertension

“…Kurisu et al. reported that eplerenone for 24 weeks significantly decreased Ad in hypertensive patients with coronary artery disease (126.3 ± 18.1 ms to 118.6 ± 19.2 ms, P < 0.05) . In their study, 10 of 17 patients were treated with ACEIs or ARBs.…”

Envelopment filter and K-means for the detection of QRS waveforms in electrocardiogram

“…Step 2: generate a new signal, based on cubic Hermite interpolation, which crosses each minimum and goes through the first and final value of the input data [25]. It is defined by (1), where h 00 , h 10 , h 01 , h 11 are four Hermite basis functions, m i , m i+1 , ν i , and ν i+1 are local minimums and their tangents in this interval, x i is the time position of local minimums from step 1, and…”

“…One of the most common pieces of information that can be read from the ECG is the heart rate (HR) which requires the detection of its most prominent feature: the QRS complex, which states the time the ventricular systole starts. The other waves may have a role in the detection of different cardiac diseases and in the estimation of parasympathetic and sympathetic activation [1][2][3][4][5][6][7], and their localization is easier when QRS complexes are determined.…”