Effects of Escitalopram on Anxiety and Respiratory Responses to Carbon Dioxide Inhalation in Subjects at High Risk for Panic Disorder

Coryell, William; Rickels, Heather

doi:10.1097/jcp.0b013e31819a8d96

Cited by 12 publications

(6 citation statements)

References 43 publications

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“…Investigations in small groups of patients with panic disorder found that treatment with different SSRIs and SNRIs reduced subjective anxiety following 5 and 7% CO 2 challenge, when compared with baseline, pre-treatment inhalation (Gorman et al 2004). However, a larger study involving 3 min of 5% CO 2 in individuals “at high risk of panic disorder” found that 2-week administration of the SSRI escitalopram had no effect on self-report or autonomic indicators of anxiety (Coryell & Rickels 2009). Given that SSRIs typically take 2–4 weeks to exert notable therapeutic effects in GAD, longer drug administration may be needed to generate valid results.…”

Section: Neurochemistrymentioning

confidence: 99%

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Bandelow

Baldwin

Abelli

et al. 2016

The World Journal of Biological Psychiatry

268

165

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Section: Neurochemistrymentioning

confidence: 99%

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Bandelow

Baldwin

Abelli

et al. 2016

The World Journal of Biological Psychiatry

268

165

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“…The use of 5-HT 2/3 R antagonist significantly reduces the apnoea index in sleep apnoea patients but also reveals sedation and weight-gain as unwarranted side effects (Carley et al, 2007). A recent placebo controlled clinical trial completely failed to show effective treatment of respiratory abnormality in panic disorder (Coryell and Rickels, 2009). …”

Section: Therapeutic Use Of Serotonergic Drugs In Central Respiratmentioning

confidence: 99%

The role of serotonin in respiratory function and dysfunction

Hilaire¹,

Voituron²,

Menuet³

et al. 2010

Respiratory Physiology & Neurobiology

145

121

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Serotonin (5-HT) is a neuro-modulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre-and postnatal development of neural circuits. The functional implications of 5-HT is particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.

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“…The only exception for positive results with SSRI was reported in the experiment conducted by Coryell et al, 65 in which 32 subjects responsive to hypercapnia undertook both a 35% CO 2 and a 5% CO 2 challenge test, followed by randomized allocation to receive a 2-week course of either 10 mg/d of escitalopram or placebo. At the end of the treatment/placebo period, tests were repeated, and the team concluded that escitalopram did not produce greater changes than placebo in panic responses or in ventilatory abnormalities seen during CO 2 exposure.…”

Section: Tricyclic Antidepressants and Ssrismentioning

confidence: 96%

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

Amaral

Spadaro

Pereira³

et al. 2013

Rev. Bras. Psiquiatr.

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This systematic review assesses the current state of clinical and preclinical research on panic disorder (PD) in which the carbon dioxide (CO 2 ) challenge was used as a trigger for panic attacks (PAs). A total of 95 articles published from 1984 to 2012 were selected for inclusion. Some hypotheses for PD evolved greatly due to the reproducibility of PAs in a controlled environment using the safe and noninvasive CO 2 test. The 35% CO 2 protocol was the method chosen by the majority of studies. Results of the test report specific sensitivity to hypercapnia in PD patients of the respiratory PD subtype. The CO 2 challenge helped assess the antipanic effects of medication and nonpharmaceutical approaches such as physical exercise and cognitive behavioral therapy. The test was also used in studies about the genetic component of PD, in which twins and relatives of PD patients were analyzed.

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Effects of Escitalopram on Anxiety and Respiratory Responses to Carbon Dioxide Inhalation in Subjects at High Risk for Panic Disorder

Abstract: Escitalopram did not produce greater changes than placebo in panic responses or in ventilatory abnormalities seen during CO2 exposure. Future studies concerning the effects of antidepressants on responses to CO2 challenge should use a placebo-controlled design.

Cited by 12 publications

References 43 publications

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

The role of serotonin in respiratory function and dysfunction

The carbon dioxide challenge test in panic disorder: a systematic review of preclinical and clinical research

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