Effects of estrogen deficiency on liver function and uterine development: assessments of <i>Medicago sativa's</i> activities as estrogenic, anti-lipidemic, and antioxidant agents using an ovariectomized mouse model

Jdidi, Hajer; Kouba, Fatma Ghorbel; Aoiadni, Nissaf; Abdennabi, Raed; Turki, Mouna; Makni‐Ayadi, Fatma; Feki, Abdelfattah El

doi:10.1080/13813455.2019.1625927

Cited by 9 publications

(6 citation statements)

References 47 publications

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“…Ovariectomy causes metabolic disturbances, which influences the liver by the generation of reactive oxygen species (Jdidi et al, 2019; Koubaa‐Ghorbel et al, 2020). Estrogen has an antioxidant activity by preventing the hydroxylation of guanine DNA‐bases (Agarwal & Doshi, 2013).…”

Section: Discussionmentioning

confidence: 99%

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

et al. 2021

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This study evaluates the modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum-graecum L. (PE-TFG) seed extract in ovariectomized rats.The HPTLC method was used for standardization and to quantify the diosgenin in PE-TFG. For testing PE-TFG in rats, the total duration of treatment was 12-weeks, and the rats were sacrificed on week 12. The tissue samples such as blood, liver, heart, and aorta were isolated for testing inflammatory markers such as adiponectin, leptin, PPARγ, TNFα, lipid profile, hepatic markers, antioxidants, and oxidative stress markers. The PE-TFG treatment decreased the elevation of total cholesterol, triglyceride, AST, and ALT. Upon PE-TFG treatment, there was a significant increase in adiponectin and PPARγ mRNA expression. Leptin and TNFα were normal after treatment with PE-TFG seed extract. Further, micro-steatosis of hepatocytes marked glomerular hypertrophy in the kidney and increased thickness of tunica intima and media of common carotid artery was reversed after treatment with PE-TFG. Practical applicationsTrigonella foenum-graecum L. is a curative plant used to treat inflammatory conditions like diabetes, obesity, dyslipidemia, arthritis, cancer, and digestive disorders. In our study, PE-TFG supplementation has a protective effect on OVX-induced inflammation, oxidative stress, mRNA expression of adiponectin and PPARγ, hepatic steatosis, and decreased thickness of tunica intima and media of common carotid artery.

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Section: Discussionmentioning

confidence: 99%

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

et al. 2021

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“…The marked changes observed in EPP calves are likely driven by the increasing production of estradiol (not evaluated in this study) by growing follicles. The circulating estradiol promotes both uterine growth [23] and somatic development [5], and ovarian activity at this early age seems to be important for the acquisition of primary and secondary sexual characteristics. In IPP calves, on the other hand, increases in body weight or size were associated with a stabilization rather than proportional changes in ovarian activity.…”

Section: Discussionmentioning

confidence: 99%

Reproductive developmental dynamics during the early and intermediate prepuberal periods in Nelore breed (Bos indicus) calves

Kawamoto

Viana

Franco

et al. 2021

Preprint

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The demand for calves as oocyte donors for in vitro embryo production is growing. However, Bos indicus have a late puberty, and some aspects of the reproductive physiology during the prepubertal period remain unclear. We characterized endocrine and morpho-functional reproductive features in Nelore calves (n=8) at 2-5 (early prepubertal period, EPP) and from 8-11 months old (mo., intermediate prepubertal period, IPP). The calves’ ovaries and uterus were B-mode transrectal ultrasonography examined, and blood samples were collected every second week. The antral follicles number and size, and ovarian and uterine horn diameters, were recorded, and plasma FSH and LH concentrations were measured (RIA). Non-pregnant, non-lactating cyclic Nelore cows (n=8) were used as controls for endocrine endpoints. Somatic development was monitored by monthly weighing, and 3D scanning of the rump area. The somatic and endocrine endpoints were compared within and between EPP and IPP, and between each period and control cows. Associations were determined by the Spearman correlation method, and the developmental rates were determined by non-linear regression. All morphological endpoints, except antral follicle count, increased (P < 0.001) from the EPP to the IPP. However, within each period differences occurred only at EPP. During the EPP LH and FSH plasma concentrations were similar (P > 0.05), whereas during the IPP LH was lower (P < 0.05) and FSH was higher (P < 0.001) than control cows. The EPP calves showed moderate to high positive correlations among ovarian, uterine, and somatic endpoints. Conversely, the IPP such correlations were mostly weak. In summary, distinct ovarian activity and development patterns of primary and secondary sexual characteristics occurred in Nelore calves at 2-5 mo compared to 8-11 mo.

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“…In summary, phytoestrogens maintain the balance of oxidation/antioxidant system directly or indirectly to achieve antioxidant effect in vivo and in vitro models. Table 2 summarizes the basic research of other phytoestrogens on improving oxidative stress in ovariectomized models (Baeza et al, 2010;Chulikhit et al, 2021;Jdidi et al, 2021;Ltaif et al, 2021).…”

Section: Reducing Oxidative Stressmentioning

confidence: 99%

Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women

Zhao,

Shi,

Shang

et al. 2023

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal women has significantly increased. Studies have shown that estrogen deficiency is the main reason for this situation, and supplementing estrogen has become a new direction for preventing the occurrence of postmenopausal fatty liver. However, although classical estrogen replacement therapy can reduce the incidence of postmenopausal NAFLD, it has the risk of increasing stroke and cardiovascular diseases, so it is not suitable for the treatment of postmenopausal NAFLD. More and more recent studies have provided evidence that phytoestrogens are a promising method for the treatment of postmenopausal NAFLD. However, the mechanism of phytoestrogens in preventing and treating postmenopausal NAFLD is still unclear. This paper summarizes the clinical and basic research evidence of phytoestrogens and reviews the potential therapeutic effects of phytoestrogens in postmenopausal NAFLD from six angles: enhancing lipid metabolism in liver and adipose tissue, enhancing glucose metabolism, reducing oxidative stress, reducing the inflammatory response, regulating intestinal flora, and blocking liver fibrosis (Graphical Abstract).

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Effects of estrogen deficiency on liver function and uterine development: assessments of Medicago sativa's activities as estrogenic, anti-lipidemic, and antioxidant agents using an ovariectomized mouse model

Cited by 9 publications

References 47 publications

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

Modulation of inflammatory markers by petroleum ether fraction of Trigonella foenum‐graecum L. seed extract in ovariectomized rats

Reproductive developmental dynamics during the early and intermediate prepuberal periods in Nelore breed (Bos indicus) calves

Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women

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