Effects of estrogen on the basal ganglia

Hartesveldt, Carol Van; Joyce, Jeffrey N.

doi:10.1016/0149-7634(86)90029-1

Cited by 232 publications

(94 citation statements)

References 159 publications

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“…Our results, as well as those from other laboratories, have demonstrated that the corpus striatum (CS) is an important target site of the CNS for both estrogen and progesterone (3)(4)(5)(6). The role of the male gonadal steroid hormone, testosterone, upon the nigro-striatal dopaminergic system has received relatively less attention.…”

mentioning

confidence: 67%

Effects of Orchidectomy on Nigro‐Striatal Dopaminergic Function: Behavioral and Physiological Evidence

Dluzen

Ramírez

1989

J Neuroendocrinology

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In the present experiments, we examined the effect of castration upon two indices of nigro-striatal dopaminergic function in the male rat. In Experiment I, differences in spontaneous locomotor behavioral activity between intact and castrated male rats were examined. The total distance traveled, horizontal activity and mean revolutions of castrated male rats were significantly greater than that of intact males. No significant differences between intact and castrated males were obtained for vertical activity. In Experiment 11, the spontaneous in vifrodopamine release from the corpus striatum of intact and castrated rats as sampled during the light-phase (1500 h) and dark-phase (2400 h) of the photoperiod was examined. At both time periods, the spontaneous in vifrodopamine release of castrated males was significantly greater than that of intact males. Both intact and castrated males showed statistically significant increases in dopamine release at the 2400 h compared to the 1500 h time period. To examine if testicular hormones were responsible for these castration induced changes in dopamine release, in Experiment Ill we treated castrated male rats with testosterone propionate. Administration of testosterone propionate (0.1 mg/day x 5 days) significantly reduced in vifro dopamine release compared to untreated or castrated male rats receiving vehicle treatment. These results demonstrate that testicular hormones, most likely testosterone, have a markedly suppressive effect upon the nigro-striatal dopaminergic system as evidenced from changes in spontaneous behavioral activity and in vifro dopamine release.Within our laboratory, we have been interested in examining the modulatory effects of gonadal steroid hormones upon the nigrostriatal dopaminergic system of the female rat (1, 2). Our results, as well as those from other laboratories, have demonstrated that the corpus striatum (CS) is an important target site of the CNS for both estrogen and progesterone (3-6). The role of the male gonadal steroid hormone, testosterone, upon the nigro-striatal dopaminergic system has received relatively less attention. Indirect indices of dopaminergic activity as determined with amphetamine-stimulated behavioral measures have indicated that testosterone attenuates the effects of amphetamine on locomotor activity and stereotyped behavior (7-9) and the duration of specific amphetamine-stimulated behaviors in castrated male rats are prolonged compared to those of intact and castrated plus testosterone-treated male rats (10). In addition, castration reduces and testosterone reinstates yawning behavior in male rats (1 l), a behavior, which in part, appears to be under control of the dopaminergic system (12). These results suggest that, similar to that of the female, the nigro-striatal dopaminergic system of the male rat is also subject to the influences of gonadal steroids. More specifically, it would appear that testicular steroids exert a predominantly suppressive effect upon dopaminergic activity in the male rat.In this report...

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confidence: 67%

Effects of Orchidectomy on Nigro‐Striatal Dopaminergic Function: Behavioral and Physiological Evidence

Dluzen

Ramírez

1989

J Neuroendocrinology

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“…Physiological doses of estradiol rapidly shift striatal D 2 receptors from high to low affinity states (Levesque and Di Paolo 1988;Di Paolo et al 1988). Ovarian hormones increase striatal dopamine turnover (Di Paolo et al 1985) and dopamine release (van Hartesveldt and Joyce 1986;Dluzen and Ramirez 1990;Peris et al 1991;McDermott 1993) and amphetamine-stimulated dopamine release Becker and Beer 1986). This laboratory reported that the rates for both dopamine uptake and release in the striatum of naïve female rats are significantly higher than in males (Walker et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Gonadal and especially ovarian hormones have been investigated as likely modulators of these sex differences in behavior. Ovarian hormone effects on stimulant responses are complex, as ovariectomy and estrous cycle studies sometimes provide apparently contradictory results (van Hartesveldt and Joyce 1986). Two studies (Savageau and Beatty 1981;Camp and Robinson 1988b) found that ovariectomy did not affect amphetamine-stimulated stereotypy, while only one showed effects on locomotion (Savageau and Beatty 1981).…”

Section: ) Cocaine Increased Stereotypy Rating Horizontal and Vertmentioning

confidence: 99%

“…Female rats are also often reported to be more active than males in open-field situations (Beatty 1979). These sex differences in basal or non-stimulated behavior are likely related to the reported sex differences in open-field behavior following psychomotor stimulant administration (van Hartesveldt and Joyce 1986 25 , NO . 1 Sex Differences in Cocaine Effects 119 particularly well known for producing greater behavioral effects in female rats following acute administration (Schneider and Norton 1979;Savageau and Beatty 1981;Becker et al 1982;Camp et al 1986;Camp and Robinson 1988a).…”

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confidence: 99%

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Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Walker

Cabassa

Kaplan

et al. 2001

Neuropsychopharmacology

112

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Sex differences in biological substrates of drug use and addiction are poorly understood. The present study investigated sexual dimorphisms in motor behavior following acute cocaine administration (10, 20, or 40 mg/ kg, i.p Little is known about sex differences in biologic substrates of drug taking and addiction. However, an emerging literature documents that sex differences in the behavioral responses to addictive drugs exist in humans. A sex difference in human affective responses to cocaine has been reported in one study in which females reported more nervousness than males following intranasal cocaine (Kosten et al. 1996). Lukas and coworkers (1996) showed that cocaine induced similar cardiovascular and affective responses in men and women, although plasma concentrations of cocaine were lower in women. In a laboratory setting, cocaine cues induced more drug craving in female than male addicts (Robbins et al. 1999). These results suggest that women may be more sensitive to cocaine than men. In fact, women begin using cocaine and enter treatment at earlier ages than men (Griffin et al. 1989;Mendelson et al. 1991) and have more severe cocaine use at intake than men (Kosten et al. 1993). .). Cocaine increased stereotypy rating, horizontal and vertical activity in both sexes, and effects were always greater in females than males. A population analysis using data from multiple experiments indicated that horizontal activity scores were normally distributed in males butSex differences in spontaneous and drug-stimulated behavior have been carefully studied in animals. Probably the most robust sex difference in behavior is the observation that female rats exhibit more running wheel activity than males (for review see Beatty 1979). Female rats are also often reported to be more active than males in open-field situations (Beatty 1979). These sex differences in basal or non-stimulated behavior are likely related to the reported sex differences in open-field behavior following psychomotor stimulant administration (van Hartesveldt and Joyce 1986 25 , NO . 1 Sex Differences in Cocaine Effects 119 particularly well known for producing greater behavioral effects in female rats following acute administration (Schneider and Norton 1979;Savageau and Beatty 1981;Becker et al. 1982;Camp et al. 1986;Camp and Robinson 1988a). Acute cocaine administration has also been reported to induce greater behavioral effects in female rats (van Haaren and Meyer 1991;Haney et al. 1994;Bowman and Kuhn 1996) and in mice (Sershen et al. 1998). However, in other reports, sex differences in acute cocaine-stimulated motor behavior were not observed in naïve Sprague-Dawley rats (Craft and Stratman 1996) and in three other rat strains (Cailhol and Mormede 1999). Thus, better evidence of sex-differences in acute behavioral effects in intact animals exists for amphetamine than cocaine. Gonadal and especially ovarian hormones have been investigated as likely modulators of these sex differences in behavior. Ovarian hormone effects on stimulant respon...

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“…However, their study group consisted of 21 male volunteers and the age drogen receptors 32 . This relationship is driven by estrogen that regulates the activity of dopamine-containing fibres originating in the midbrain and terminating in the basal ganglia 33 . The combination of sex hormones, dopamine release and basal ganglia volume contribute to higher prevalence of ADHD in male children having small basal ganglia volume 34 .…”

Section: Discussionmentioning

confidence: 99%

Basal Ganglia Volumes: MR-Derived Reference Ranges and Lateralization Indices for Children and Young Adults

Wyciszkiewicz

Pawlak

2014

Neuroradiol J

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SUMMARY -Previous studies indicate rightward asymmetry of the caudate nucleus (CN) volume and leftward asymmetry of the putamen (PN) and globus pallidus (GP). This study aimed to estimate reference ranges for basal ganglia asymmetry in a large cohort of healthy individuals (n= 949), aged seven to 21 years. MRI images of 949 (320 female, mean age 12.6 +/-3.3, range 7-21) healthy individuals were reviewed. Volumetric measurements of the basal ganglia were obtained using automated segmentation (FreeSurfer). We computed two lateralization indices: (L-R)/(L+R) (LI) and right/left ratio (RLR). Tolerance interval estimates were used to calculate reference ranges. Rightward asymmetry of the CN and leftward asymmetry of the PN and GP were confirmed. PN and GP volume decreased with age, but CN volume did not. The lateralization index decreased

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Effects of estrogen on the basal ganglia

Cited by 232 publications

References 159 publications

Effects of Orchidectomy on Nigro‐Striatal Dopaminergic Function: Behavioral and Physiological Evidence

Effects of Orchidectomy on Nigro‐Striatal Dopaminergic Function: Behavioral and Physiological Evidence

Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Basal Ganglia Volumes: MR-Derived Reference Ranges and Lateralization Indices for Children and Young Adults

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