Effects of estrogenic (o,p′-DDT; octylphenol) and anti-androgenic (p,p′-DDE) chemicals on indicators of endocrine status in juvenile male summer flounder (Paralichthys dentatus)

Influence of Propylparaben on Vitellogenesis and Sex Ratio in Juvenile Zebrafish (Danio rerio)

“…Unfortunately, in the positive control group the sex ratio could not be determined, since the exposure dose of E-2 was excessively high. The impossibility of sex determination of E-2 exposed fish supports the statement of Mills et al (2001), who reported gonadal regression in male summer flounder as a consequence of E-2 exposure. Indeed, in our experiment, gonads of fish exposed to E-2 either did not develop or had regressed prior to the end of the experiment when fish were sampled.…”

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

“…The dicarboximide fungicide vinclozolin is also shown to be an anti-androgenic EDC, but it is rather its metabolites that have the greater half-lives and mobility in water necessary to cause endocrine-disrupting effects (Bayley et al, 2003). Furthermore, metabolites from parental EDCs may modulate other endocrine system pathways as well, such as the organochloride insecticide DDT, which is a known oestogenic EDC, but its metabolite p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) is shown to rather have antiandrogenic activity (Mills et al, 2001). Also, although some breakdown products of EDCs may not have any endocrinedisrupting activity, these components might contribute towards an elevated pathogenic effect of another EDC (i.e.…”

Assessment of the health status of wild fish inhabiting a cotton basin heavily impacted by pesticides in Benin (West Africa)

“…According to Mills et al (2001), the decrease in the GSI is usually explained by the presence of histopathological changes in the gonads (gonad regression). In this study, the lower GSI observed in males from the contaminated sites may be related to the presence of histopathological alterations most likely resulting from exposure to agricultural pesticides as previously reported by other authors (Jobling et al, 1996;Christiansen et al, 1998;Gimeno et al, 1998;Mdegela et al, 2010;Sayed et al, 2012).…”

“…Similar elevations of HSI were also observed by Van Dyk et al (2012) in African catfish caught in rivers impacted by mining, industrial and urban effluents in South Africa, or by Corsi et al (2003) in Grass goby, Zosterisessor ophiocephalus, caught in the Orbetello Lagoon (Italy) and exposed to chlorinated and aromatic hydrocarbons. The HSI increase can be linked, on the one hand, to macroscopic abnormalities such as stones and nodules of fat (Van Dyk et al, 2012); on the other hand, they may be attributed to the increased synthesis of vitellogenin from the stimulation of high plasma E2 levels (Mills et al, 2001). When toxic compounds exceed the detoxification level of the liver, high concentrations of a toxicant induced liver bio-transformer activity and provoked modifications in the normal hepatic structure.…”