Effects of Ethane Dimethanesulfonate on the Structure of Adult Male Rat Adrenal Cortex

Plećaš, B.; Glavaski, Aleksandra; Savić, Vojin; Hristić, M; Đurić, Darka Stošić; Solarović, T

doi:10.1006/phrs.1997.0186

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…The current data are consistent with previous studies regarding the deleterious effect of EDS on steroidogenic cells of adult male rat adrenal cortex. 1 Using model of EDS treated rats we have found that the dynamic of 11β HSD2 expression correlated with the changes of serum testosterone levels following the exposure with EDS. 9 The lowest 11 βHSD2 staining intensity was found 7 days after EDS followed by progressive increase in the immunoreactivity toward days 14 and 21.…”

Section: Discussionmentioning

confidence: 90%

“…The changes were most prominent in the inner zones -zona fasciculata and zona reticularis. 1 11β hydroxysteroid dehydrogenase (11β HSD) catalyzes the interconversion of biologically active cortisol to cortisone in man and cotricosterone to 11-dehydrocorticosterone in rodents and plays a crucial role in regulating corticosteroid hormone action. 2 Inhibition of 11β HSD allows access of cortisol or corticosterone to the mineralcorticoid receptors where it acts as a mineralcorticoid.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

11β Hydroxysteroid Dehydrogenase Type 2 in the Adrenal Gland by Testosterone Withdrawal of Adult Rats

Koeva

Bakalska²,

Petrova³

et al. 2010

Folia Medica

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

11β Hydroxysteroid Dehydrogenase Type 2 in the Adrenal Gland by Testosterone Withdrawal of Adult Rats

Koeva

Bakalska²,

Petrova³

et al. 2010

Folia Medica

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“…EDS can exert its cytotoxic effect on other cell types e.g. the parenchymal cells of the adrenal cortex (Plecas et al 1997), but its main cytotoxic targets are mature adult Leydig cells. The counterpart in females to adult Leydig cells in males, are steroidogenic ovarian theca cells, however EDS did not affect the thecal cells (Smart et al 1990).…”

Section: Adult Leydig Cell Ablation/regeneration Modelmentioning

confidence: 99%

Early life programming of adult Leydig cell function

Kilcoyne¹,

Smith²,

Jobling³

et al. 2014

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My most sincere gratitude is extended to my supervisor, Richard Sharpe, who not only imparted his wisdom of Science, but also his inspiring enthusiasm at each stage of my PhD. I could not have asked for a more patient, supportive and caring supervisor. You always said Friday was the 'day for results' and that certainly rang true on several Fridays, be it good or bad. Regardless of the outcome, you were always there to listen, advise and discuss.A big thank you to my second supervisor, Lee Smith, for his thought-provoking and helpful input throughout my PhD and for the critical assessment of this thesis.Thank you to the Sharpe group, both present and past members, in particular Marion Walker, Chris McKinnell, Sheila Macpherson, Sander van den Driesche, Afshan Dean, Tom Chambers and Rod Mitchell. Thank you especially to Chris and Sheila for their invaluable help, to Tom for his assistance with ChIP, and to Laura O'Hara for the use of her mouse model. Thank you all for teaching me essential lab techniques, and answering all of my questions, without which, this thesis would never have existed.A big thank you to those who started out as work colleagues, but have now become close friends. To Fiona, from learning about Spirogyra many moons ago to the present! To Lorraine, for the numerous fun-filled nights out and for her daily phone calls to keep me going! To Afshan, for always organising a well needed night out! To my 'office buddies', Doug and Fiona, for always having time to assist with anything I ever needed. Thank you for lending an ear and making me laugh; be it over a coffee or a few beers.Thank you to the girls back home, for always checking in on me and making sure there was always a weekend planned to look forward to, especially Caitriona, Sile, Helena, Edwenia, Therese, and Rebecca. I cannot thank Andrew enough for his unwavering support, patience and motivation. Thank you for never once doubting my capability, even at those times when I did. And of course, for casting an analytical eye over this thesis at the end. Thank you for being there for me. Oh and I know it's my turn to cook... Finally and most importantly, thank you to my family; Mam, Dad, Lorna, Cora, AG, John and the new arrivals! Thank you for your support and encouragement every single day, so that home never felt too far away. "Furthermore" thank you to Cora for taking the time to read over this thesis! Thank you to my parents for providing me with everything I have ever needed; support, love and laughter. Without you, none of this would have been possible. Sin é, Buíochas le Dia.

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Dynamics of Leydig Cell Regeneration After EDS

Teerds¹,

Rijntjes²

Contemporary Endocrinology

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Effects of Ethane Dimethanesulfonate on the Structure of Adult Male Rat Adrenal Cortex

Cited by 7 publications

References 15 publications

11β Hydroxysteroid Dehydrogenase Type 2 in the Adrenal Gland by Testosterone Withdrawal of Adult Rats

11β Hydroxysteroid Dehydrogenase Type 2 in the Adrenal Gland by Testosterone Withdrawal of Adult Rats

Early life programming of adult Leydig cell function

Dynamics of Leydig Cell Regeneration After EDS

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