Effects of ethanol extract of propolis on histopathological changes and anti‐oxidant defense of kidney in a rat model for type 1 diabetes mellitus

Sameni, Hamid Reza; Ramhormozi, Parisa; Bandegi, Ahmad Reza; Taherian, Aliakbar; Mirmohammadkhani, Majid; Safari, Manouchehr

doi:10.1111/jdi.12459

Cited by 60 publications

(66 citation statements)

References 35 publications

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“…Propolis differs in composition due to differences in local vegetations, pharmacological activity of propolis is highly variable depending on its geographic origin [17,22]. In our study, reduced severity of dysplasia in cases, groups might be related to the presence of these active ingredients in propolis.…”

Section: Discussionmentioning

confidence: 61%

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

Salehi¹,

Mina

Moghadamnia

et al. 2017

JCDR

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Introduction: Since oral cancer is one of the causes of mortality, the use of materials or methods that can reduce cancer or prevent its progression has particular importance.Aim: Aim of the study was to evaluate the antitumor effects of Iranian propolis on dysplastic changes of oral mucosa in rats. Materials and Methods:This study was performed on 28 Wistar male rats (aged 7-11 weeks, 160±20 g). They were divided into four groups of seven rats. The Group 1 received: 0.5% 7,12-Dimethylbenz[a]anthracene (DMBA), the Group 2: 0.5% DMBA and 100 mg/kg propolis, the Group 3: 0.5% DMBA and 200 mg/ kg propolis, and the Group 4: 0.5% DMBA and 400 mg/kg propolis. DMBA in all groups was administered topically (brush) and propolis was injected intraperitoneally. DMBA was brushed twice on the lingual dorsum three times a week for 20 weeks. Propolis injection just every other day and in the days after DMBA was administered for 20 weeks. Rats were sacrificed, and histological examinations were performed on tongue specimen.Results: Propolis can reduce the degree of dysplasia in doses 100 mg/kg, 200 mg/kg, and 400 mg/kg compared to control (Group 1) (p=0.017, p=0.02, and p=0.002, respectively). Conclusion:The results of this study showed propolis can dose-dependently prevent DMBA-induced dysplasia of the oral mucosa in animal model.

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Section: Discussionmentioning

confidence: 61%

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

Salehi¹,

Mina

Moghadamnia

et al. 2017

JCDR

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“…In this experimental study, the animals were randomly divided into six groups (n=8/each) as follows: 1) Control group (C) included 21-day pups without any intervention, 2) Sham group included 15-day pups that were beside their mothers during this period and received 0.1 ml saline solution daily, 3) Stress group (S), included 15-day pups that were separated from their mothers 6 hr/day during this period, 4) the S+P50 group which were under stress and received 50 mg/kg EIP daily, 5) the S+P100 group which were under stress and received 100 mg/kg EIP daily, and 6) S+P200 group which were under stress and received 200 mg/kg EIP daily ( 16 - 18 ).…”

Section: Methodsmentioning

confidence: 99%

“…Our earlier studies have shown that the Iranian propolis extract could enhance the antioxidant levels and histopathological changes in the kidneys and control blood glucose and modulate some of the biochemical factors of diabetic rats, also prevent from increasing serum corticosterone and brain MDA levels and from decreasing ferric reducing antioxidant power (FRAP), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels in brain under prenatal stress ( 16 - 18 ). Propolis is one of the strongest natural antioxidants.…”

Section: Introductionmentioning

confidence: 99%

The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress

Arabameri

Sameni

Bandegi

2017

IJRM

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Background:Stress in infancy has dramatic effects on different systems, including the nervous system, endocrine, immune, reproductive and etc.Objective:The purpose of this study was to investigate the effects of extract of Iranian propolis (EIP) on ovarian tissue and oxidative stress in rats with maternal separation stress.Materials and Methods:48 immature female rats were divided randomly into six groups. 1) Control group, 2) Control group+saline, 3) Stress group, includes infants that were separated from their mothers 6 hr/day, the 4th, 5th and 6th groups consisted of infants who in addition to daily stress received 50, 100 and 200 mg/kg of EIP, respectively. Then serum corticosterone, 17-beta-estradiol, malondialdehyde, total superoxide dismutase, glutathione peroxidase and ferric reducing antioxidant power levels were measured. The ovarian sections were stained by H&E, PAS, and TUNEL methods and were studied with optical microscopy. Results:Stress increased the blood serum corticosterone levels and 17-beta-estradiol reduced significantly (p<0.001) and EIP prevented from this changes (p<0.01). EIP significantly increased the number of ovarian follicles, oocytes and oocytes diameter in neonatal rat following stress (p<0.01). EIP also significantly decreased the number of atretic follicles, TUNEL+granulosa cells, malondialdehyde levels and increased ferric reducing antioxidant power, total superoxide dismutase and glutathione peroxidase serum levels in neonatal rats following stress. The dose of 200 mg/kg EIP was more effective.Conclusion:This Study showed that the Iranian Propolis significantly could prevent oxidative stress and histopathological changes in the ovary of the neonatal rat the following stress.

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“…The extract was prepared according to a published method [12]. In summary, propolis was cut into small pieces (≈2-3 mm) and mixed with 99% ethanol, at a ratio of 1:10 (propolis:ethanol).…”

Section: Preparation Of Propolis Ethanolic Extract (Eep)mentioning

confidence: 99%

Development of Bio-Active Patches Based on Pectin for the Treatment of Ulcers and Wounds Using 3D-Bioprinting Technology

et al. 2020

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Biodegradable 3D-printable inks based on pectin have been developed as a system for direct and indirect wound-dressing applications, suitable for 3D printing technologies. The 3D-printable inks formed free-standing transparent films upon drying, with the latter exhibiting fast disintegration upon contact with aqueous media. The antimicrobial and wound-healing activities of the inks have been successfully enhanced by the addition of particles, comprised of chitosan and cyclodextrin inclusion complexes with propolis extract. Response Surface Methodology (RSM) was applied for the optimization of the inks (extrusion-printing pressure, shrinkage minimization over-drying, increased water uptake and minimization of the disintegration of the dry patches upon contact with aqueous media). Particles comprised of chitosan and cyclodextrin/propolis extract inclusion complexes (CCP), bearing antimicrobial properties, were optimized and integrated with the produced inks. The bioprinted patches were assessed for their cytocompatibility, antimicrobial activity and in vitro wound-healing properties. These studies were complemented with ex vivo skin adhesion measurements, a relative surface hydrophobicity and opacity measurement, mechanical properties, visualization, and spectroscopic techniques. The in vitro wound-healing studies revealed that the 3D-bioprinted patches enhanced the in vitro wound-healing process, while the incorporation of CCP further enhanced wound-healing, as well as the antimicrobial activity of the patches.

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Effects of ethanol extract of propolis on histopathological changes and anti‐oxidant defense of kidney in a rat model for type 1 diabetes mellitus

Cited by 60 publications

References 35 publications

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

An Intervention Airing the Effect of Iranian Propolis on Epithelial Dysplasia of the Tongue: A Preliminary Study

The effects of propolis extract on ovarian tissue and oxidative stress in rats with maternal separation stress

Development of Bio-Active Patches Based on Pectin for the Treatment of Ulcers and Wounds Using 3D-Bioprinting Technology

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