Effects of ethanol on plasma protein shedding in the human stomach

Brassinne, A

doi:10.1007/bf01297237

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…Free radicals created by HCl-ethanol injury are thought to attack the protein which might lead to a reduction in the protein levels [31]. It has also been reported that ulcerative lesions of the gastrointestinal tract may be associated with increased loss of protein [42], and this was also observed in our study.…”

Section: Discussionsupporting

confidence: 85%

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Biochemical Studies Evaluating the Antiulcerogenic Potential of Ocimum sanctum in Experimentally Induced Peptic Ulcers in Rats.

Vanisree

Devaki

1995

J. Clin. Biochem. Nutr.

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SummaryThe effect of pretreatment with Ocimum sanctum, an herbal drug, on HCl-ethanol-induced gastric lesions in rats was investigated with respect to acid/pepsin, lipid peroxidation, antioxidant status, and glycoproteins in the gastric mucosa. The increase in volume and acidity of the gastric juice and the decrease in peptic activity in HClethanol-exposed mucosa were maintained at near normalcy in O. sanctum-pretreated mucosa. The increase in lipid peroxidation, decrease in activity of antioxidants in the ulcerated rats were maintained at normalcy in the pretreated rats. Decrease in protein and glycoprotein of the ulcerated mucosa were found to be maintained to near normal in O. sanctum-treated mucosa. These results suggest that by virtue of its ability to decrease acidity and increase the mucosal defense, the use of O. sanctum as an antiulcerogenic agent is justified.Key Words: Ocimum sanctum, gastric lesions, acid, pepsin, lipid peroxidation Peptic ulcer is a multifaceted disease with a complex pluricausal etiology that is not fully understood. The last several decades have witnessed enormous progress in ulcer drug discovery and development, including a Nobel prize to Sir James Black for his seminal work on histamine H2 receptors and their blockers, a mainstay of current drug management of ulcers. Despite these advances, the ulcer remains somewhat of a medical enigma [1].Peptic ulcer refers to the group of ulcerative disorders of the upper gastrointestinal tract involving principally the most proximal portion of the duodenum and the stomach, which have in common the participation of acid/pepsin [2]. It occurs

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Section: Discussionsupporting

confidence: 85%

“…It was reported that ethanol and bile salts had similar effects [41]. Other supporting evidence is that alcohol increases the loss of protein into the gastric content in the presence of HC1 [42].…”

Section: Discussionmentioning

confidence: 84%

Biochemical Studies Evaluating the Antiulcerogenic Potential of Ocimum sanctum in Experimentally Induced Peptic Ulcers in Rats.

Vanisree

Devaki

1995

J. Clin. Biochem. Nutr.

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“…The mucosal proteins are easily susceptible to oxidative free radicals produced by HCl±ethanol, resulting in corrosion, disruption and disintegration of mucosal cells (Davenport 1967;Guth et al 1984). Alcohol intake is reported to increase the loss of mucosal proteins into the gastric juice in the presence of HCl (Brossinne 1979). Increased loss of protein in the ulcerated condition might be a major factor involved in the induction of ulcerative lesions of the gastrointestinal tract.…”

Section: Groupsmentioning

confidence: 99%

Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl-ethanol-induced ulcer in rats

Anandan

Nair

Mathew

2004

Journal of Pharmacy and Pharmacology

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The anti-ulcerogenic effect of chitin and chitosan against ulcer induced by HCl-ethanol in male Wistar rats was studied. Levels of acid output, pepsin, protein, lipid peroxides and reduced glutathione and the activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), catalase (CAT) and superoxide dismutase (SOD) were determined in the gastric mucosa of normal and experimental groups of rats. A significant increase in volume and acidity of the gastric juice was observed in the ulcer-induced group of rats. Peptic activity was significantly decreased as compared with that of normal controls. In the rats pre-treated with chitin and chitosan 2% along with feed, the volume and acid output and peptic activity of gastric mucosa were maintained at near normal levels. The level of lipid peroxidation was significantly higher in the ulcerated mucosa when compared with that of normal controls. This was paralleled by a decline in the level of reduced glutathione and in the activity of antioxidant enzymes like GPx, GST, CAT and SOD in the gastric mucosa of ulcer-induced rats. Also, the levels of mucosal proteins and glycoprotein components were significantly depleted in ulcerated mucosa. The pre-treatment with chitin and chitosan was found to exert a significant anti-ulcer effect by preventing all the HCl-ethanol-induced ulcerogenic effects in experimental rats.

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“…The leakage or transudation of plasma from microcapillaries into interstitial spaces, and then into the lumen of the stomach, is a normal occurrence (Brassinne, 1979;Hollander & Horowitz, 1962), and is increased considerably when gastric mucosa is damaged experimentally (Brassinne, 1979;Sober et al, 1950) or through disease (Brassinne, 1974;Jarnum & Jensen, 1972). Thus, H. pylori colonizing the gastric microenvironment will be exposed to plasma, and Abbreviations: CLV, curvilinear velocity; CR, chemotactic response.…”

Section: Introductionmentioning

confidence: 99%

Chemotactic response of Helicobacter pylori to human plasma and bile

Worku

Karim

Spencer

et al. 2004

Journal of Medical Microbiology

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To clarify further the role of chemotaxis in Helicobacter pylori colonization, the in vitro bacterium response to human plasma and bile (secretions containing chemoeffector compounds that are present in the gastric mucus layer) was examined. Human plasma, after dilution to 1 % (v/v) with buffer, was found to be a chemoattractant for the motile bacillus. Human gall-bladder bile, after dilution to 2 % (v/v) with buffer, was found to be a chemorepellent, but did not cause the motility of the bacillus to be diminished after prolonged exposure. The basis of the chemoattractant effect of plasma was explored by examining how urea and 12 amino acids found in plasma affected the taxis of H. pylori. Urea and the amino acids histidine, glutamine, glycine and arginine were the strongest chemoattractants. Other amino acids were chemoattractants, with the exceptions of aspartic and glutamic acids, which were chemorepellents. The basis of the chemorepellent effect of bile was explored by examining how the six most abundant conjugated bile acids in human bile affected the taxis of H. pylori. All the bile acids were chemorepellents, with the greatest effects being demonstrated by taurocholic and taurodeoxycholic acids. The implications of these findings for H. pylori colonization of gastric epithelium are discussed.

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Effects of ethanol on plasma protein shedding in the human stomach

Cited by 12 publications

References 13 publications

Biochemical Studies Evaluating the Antiulcerogenic Potential of Ocimum sanctum in Experimentally Induced Peptic Ulcers in Rats.

Biochemical Studies Evaluating the Antiulcerogenic Potential of Ocimum sanctum in Experimentally Induced Peptic Ulcers in Rats.

Anti-ulcerogenic effect of chitin and chitosan on mucosal antioxidant defence system in HCl-ethanol-induced ulcer in rats

Chemotactic response of Helicobacter pylori to human plasma and bile

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