Effects of ethanolic fruit extract of Picralima nitida (Stapf) on fertility of pregnant rats

Mbegbu, Edmund Chidiebere; Omoja, Valentine Uneojo; Ekere, Okezie Samuel; Okoye, Chidozie Nwabuisi; Uchendu, C. N.

doi:10.1007/s00580-014-1888-8

Cited by 5 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, PNE prolongs estrous phase in rats in vivo and possessed uterotonic effects in vitro [ 17 ]. Using the chick uterotrophic assay, we have demonstrated that PNE has uterotrophic effects which were comparable to estradiol.…”

Section: Discussionmentioning

confidence: 99%

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use

Otoo¹,

Koffuor²,

Ansah³

et al. 2015

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

Background:Picralima nitida seed extract (PNE) has aphrodisiac and contraceptive effect.Aim:To investigate the effect of PNE on reproductive hormones.Materials and Methods:The size and length of the combs of white leghorn day-old chicks treated with testosterone (0.5-1.5 mg/kg), cyproterone (3-30 mg/kg), or PNE (50-500 mg/kg) for 7 days, as well as cyproterone (10, and 30 mg/kg) on PNE-induced, and PNE (50-500 mg/kg) on testosterone-induced comb growth, were measured in the chick comb test. The effect of PNE the percentage change in an oviduct-chick weight ratio of Rhode Island Red layer day-old chicks treated with 17-β-estradiol (0.1-0.9 µg), PNE (30-300 mg/kg) or vehicle, for 6 days, was determined in the chick uterotrophic assay. Liver and kidney function was well lipid, and hematological profile tests were conducted to assess safety.Results:7-day treatment with PNE and testosterone increased significantly (P ≤ 0.01-0.001) while cyproterone significantly decreased (P ≤ 0.001) comb growth dose-dependently. Qualitatively, testosterone and PNE treatment resulted in relatively brighter red combs. Cyproterone caused significant inhibition (P ≤ 0.001) of both testosterone and PNE-induced comb growth. Co-administration of testosterone and PNE suppressed comb growth significantly (P ≤ 0.001). Administration of 17-β estradiol and PNE increased (P ≤ 0.001) oviduct-chick weight ratio dose-dependently. No significant changes were observed in assessing liver and kidney function, lipid profile, and hematological parameters.Conclusion:PNE exhibits both androgenic (partial testosterone agonist) and estrogenic activity. It has no detrimental effects on the blood, liver, and kidney tissue with prolonged use.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use

Otoo¹,

Koffuor²,

Ansah³

et al. 2015

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

show abstract

“…Picralima nitida belonging to the family Apocynaceae is commonly called Picralima, Akuamma or Pile plant and its distribution is restricted to African rain forest regions. It is known as limeme (Congo), Eban or Obero (Gabon), Erin or Abeere (Yoruba), Osuigwe (Igbo) and Bamborutuk or Eban (Cameroon) ( Mbegbu, et al , 2014 ). The various parts of the plants have been used for the treatment of hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria in West African traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

In vivo anthelmintic potentials of Gongronema latifolium and Picralima nitida against gastrointestinal parasite (Heligmosomoides bakeri)

Ojo,

Idowu,

Ademolu

et al. 2023

Helminthologia

View full text Add to dashboard Cite

Summary Gastrointestinal parasites which are responsible for soil-transmitted helminthiases cause illness globally. The control of helminthiasis depends on mass distribution of anthelmintics which has been reported for its resistance, toxicity and low efficacy. In this study, anthelmintic potentials of Gongronema latifolium and Picralima nitida which have wide application in traditional medicine were determined in vivo using Heligmosomoides bakeri a naturally occurring gastro-intestinal parasite of rodents that is closely related to highly prevalent human nematode parasites. Extracts of P. nitida at 500 mg/kg had higher (p< 0.05) chemosuppression (92.45 %) than extracts of G. latifolium (65.82 %) and was highly comparable to albendazole (92.61 %). As the dose of the extracts increased from 300 to 500 mg/kg body weight, chemosuppression of 84.91 % and 92.45 % (P. nitida) and 43.54 % and 65.82 % (G. latifolium) respectively were produced. The extract of P. nitida gave deparasitization rates (p<0.05) of 72.60 % and 77.16 % at 300g/kg and 500mg/kg of body weight respectively. The glucose level and protein content reduced (p<0.05) in mice treated with extract of P. nitida when compared with extract of G. latifolium and untreated mice. Phytochemical screening revealed that P. nitida and G. latifolium contained flavonoids, alkaloids, saponins, tannins and polyphenols. Acute toxicity studies showed that Gongronema latifolium and Picralima nitida have no apparent toxic effect in mice even at the dose of 5000 mg/kg. Extracts of P. nitida and G. latifolium have anthelmintic properties that are dose-dependent, and this could offer potential lead for the development of safe, effective and affordable anthelmintics.

show abstract

“…Pharmacological investigations have proved that this plant also possesses anti-plasmodial [17], anti-diarrheic [18,19], anti-diabetic [20], analgesic [21], opioid [22], antimicrobial [23,24], antiinflammatory [21,25], anti-pyretic [26], trypanocidal [27], anti-Shigellosis [28], as well as anti-leishmanial [29] potencies. Despite the vast ethnomedical and scientific reports on the therapeutic efficacy of this plant, detailed toxicological studies and research observations associated this plant with some level of toxicity especially in higher doses and in immunecompromised animal subjects [14,30,31].…”

Section: Introductionmentioning

confidence: 99%

“…Group E received 2.5 mg/kg BW of CdCl 2 (negative control), while Group F received 5 mg/kg BW of Sildenafil (positive control); orally every other day for six weeks. Place and Duration of Study: Methodology: At the end of the experiment, blood samples were collected for haematology and Mbegbu et al; JAMPS, 14(1): 1-14, 2017; Article no.JAMPS.34359 2 serology, whereas testicular sections were collected for histopathology following the standards procedures. Data obtained were analyzed by One-way ANOVA.…”

mentioning

confidence: 99%

Haematological Profile and Some Reproductive Indices of Male Albino Rats Treated with Ethanolic Stem Bark Extract of Picralima nitida

Mbegbu

Odo

Edeh

et al. 2017

JAMPS

View full text Add to dashboard Cite

Aim:To evaluate the effects of graded doses of ethanolic stem bark extract of Picralima nitida on haematological profile, some serum reproductive hormones, sperm reserves and testicular histomorphology of male albino rats. Study Design: Thirty male albino rats, weighing between 120 and 200 grams were randomly assigned into six groups of five rats each. Group A received 0.5 ml of distilled water (normal control). Groups B, C and D received 100, 200 and 400 mg/kg BW of the extract respectively. Group E received 2.5 mg/kg BW of CdCl 2 (negative control), while Group F received 5 mg/kg BW of Sildenafil (positive control); orally every other day for six weeks. Place and Duration of Study: Methodology: At the end of the experiment, blood samples were collected for haematology and Mbegbu et al.; JAMPS, 14(1): 1-14, 2017; Article no.JAMPS.34359 2 serology, whereas testicular sections were collected for histopathology following the standards procedures. Data obtained were analyzed by One-way ANOVA. Results: The result showed that all doses of the extract increased neutrophil count, but decreased (P < 0.05) monocyte and RBC counts; 200 and 400 mg/kg BW of the extract decreased (P < 0.05) PCV values; and only 400 mg/kg of the extract reduced (P < 0.05) HB values. 200 and 400 mg/kg BW of the extract, and 2.5 mg/kg BW of CdCl 2 decreased (P < 0.05) serum testosterone and sperm counts. The normal control, 100 mg/kg BW of the extract and 5 mg/kg BW of Sildenafil had normal testicular histoarchitecture; whereas 200 and 400 mg/kg BW of the extract, and 2.5 mg/kg BW of CdCl 2 had slight, moderate and severe degeneration of the germinal epithelium and interstitium, with depletion of sperm cells in the lumen of the seminiferous tubules respectively. Conclusion: This study revealed that treatment with ethanolic stem bark extract of Picralima nitida above 100 mg/kg BW adversely affected haematological and reproductive parameters in male albino rats. Original Research Article

show abstract

Effects of ethanolic fruit extract of Picralima nitida (Stapf) on fertility of pregnant rats

Cited by 5 publications

References 10 publications

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use

Assessment of an ethanolic seed extract of Picralima nitida ((Stapf) Th. and H. Durand) on reproductive hormones and its safety for use

In vivo anthelmintic potentials of Gongronema latifolium and Picralima nitida against gastrointestinal parasite (Heligmosomoides bakeri)

Haematological Profile and Some Reproductive Indices of Male Albino Rats Treated with Ethanolic Stem Bark Extract of Picralima nitida

Contact Info

Product

Resources

About