Effects of ethyl acetate leaf extracts of &lt;i&gt;Vitex simplicifolia&lt;/i&gt; on antioxidant vitamins, sod, liver glycogen content and lipid profile in alloxan induced - diabetic wistar rats

Salim, Maulidiyah; Imam, AA; Muhammad, Sher; Dikko, A. A. U.; Tanko, Y.; Mohammed, Abdelaziz

doi:10.4314/bajopas.v10i1.27

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The method described by Salim and Dikko (2016) was employed for this study while the dose of extract to be administered was determined using the method described by Neharkar and Gaikad, (2011). Group of 20 diabetic albino rats of both sexes were used.…”

Section: Hypoglycemic Study Of the Extractmentioning

confidence: 99%

Hypoglycemic effects of seed extract of Artocarpus heterophyllus

Olli,

Olli

2023

TNPR

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Seed extract of Artocarpus heterophyllus is used in the management of diabetes in folkloric medicine, but its efficacy has not been scientifically validated. This study was carried out to evaluate the hypoglycemic effects of this seed extract. Dried and pulverized seeds of A. heteropllus were cold macerated in 80 % ethanol for 48 hours, filtered and the filtrate dried over water bath at 40ºC. Acute toxicity study and phytochemical screening were carried out. Hypoglycaemic effects of the extract (250 and 500 mg/kg) were tested on Alloxan induced hyperglycaemic model using a set of 20 diabetic albino rats of both sexes that were grouped into four (n=5). Groups I and II served as the negative and positive controls having received respectively distilled water (10 ml/ kg) and Metformin (100 mg/kg) orally. Groups III and IV received the extract (250 and 500 mg/kg) p.o. Histopathology analysis of rats’ pancreas was carried out. Raw data were subjected to one-way analyses of variance (ANOVA) followed by post hoc turkey’s test. P < 0.05 was considered to be statistically significant. The estimated oral median dose (LD50) of the extract was higher than 5000 mg/kg. Secondary metabolites such as tannins and saponins were present. The two doses (250 and 500 mg/kg) of the extract conferred a dose-related significant (p<0.05) reduction in the fasting blood sugar (FBS) levels when compared to the control. The histopathology results also revealed the hypoglycemic effect of the extract.

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Section: Hypoglycemic Study Of the Extractmentioning

confidence: 99%

Hypoglycemic effects of seed extract of Artocarpus heterophyllus

Olli,

Olli

2023

TNPR

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“…Then diabetic animals were then treated as stated. Blood glucose level was measured at 2, 4, 6, 8 and 10 hours post treatment using One Touch Ultramini Glucometer (LifeScan GmbH Switserland) [20]. Daily administration of glibenclamide, crude extract and fractions was also carried out for a period of 14 days (2 weeks) on the same animals.…”

Section: Blood Glucose Determinationmentioning

confidence: 99%

Evaluation of the anti-diabetic effect of the methanol leaf extract and fractions of Dennettia tripetala G. Bak (Annonaceae) in alloxan- induced diabetic mice

Abonyi

Omoiri

Akah

2020

J. Drug Delivery Ther.

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This study evaluated the anti-diabetic properties of the methanol extract and fractions of Dennettia tripetala leaves in alloxan diabetic rats. The crude methanol extract (ME), n-hexane (NF), ethyl acetate (EAF), butanol (BF) and water (WF) fractions, were tested for anti-diabetic activity in alloxan-induced diabetic mice. The extracts and its fractions were screened for phytochemical constituents. Glibenclamide was used as the standard anti-diabetic treatment Fasting blood glucose (FBG) levels were determined using a glucometer. Lipid profile parameters were also assessed. Histopathological examination of the pancreas was performed. The presence of glycosides, saponins, reducing sugars, fats and oil, alkaloids, carbohydrates, flavonoids, proteins and tannins were detected in ME, and the fractions. Treatment of the rats with the extract and its fractions reduced FBG levels significantly (p < 0.05) within 10 hours of acute treatment and 14 days short term treatment. The highest reduction was by the crude extract,( ME 500 mg/kg) with percentage reduction of 62.89 %. The study revealed significant (p < 0.05) reductions in serum triglyceride, serum cholesterol and LDL levels by the extracts and its fractions while a significant (p < 0.05) increase in HDL levels was evident . The effect of the extract and fractions on body weight indicated a moderate weight gain. Treatment with high dose of the extract and fractions (500 mg/kg) resulted in marked rejuvenation of the pancreatic β cells. The results of this study suggest that the leaves of Dennetia tripetala are endowed with potent anti-diabetic and antilipidemic properties. Keywords: Dennetia tripetala, Antidiabetic, Alloxan, Lipid profile, Histopathplogy.

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Effects of ethyl acetate leaf extracts of <i>Vitex simplicifolia</i> on antioxidant vitamins, sod, liver glycogen content and lipid profile in alloxan induced - diabetic wistar rats

Cited by 2 publications

References 8 publications

Hypoglycemic effects of seed extract of Artocarpus heterophyllus

Hypoglycemic effects of seed extract of Artocarpus heterophyllus

Evaluation of the anti-diabetic effect of the methanol leaf extract and fractions of Dennettia tripetala G. Bak (Annonaceae) in alloxan- induced diabetic mice

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