Effects of Exercise Interventions on Aerobic Capacity and Health-Related Quality of Life in People Living With HIV/AIDS: Systematic Review and Network Meta-Analysis

Gomes‐Neto, Mansueto; Saquetto, Micheli Bernardone; Alves, Iura Gonzalez Nogueira; Martinez, Bruno Prata; Vieira, João Paulo Bomfim Cruz; Brites, Carlos

doi:10.1093/ptj/pzab092

Cited by 13 publications

(11 citation statements)

References 65 publications

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“…Our review could not confirm that physical activity interventions had significant effects on psychological profiles, including health-related quality of life and depression. A previous review reported that the combined aerobic and resistance exercise was the most effective exercise type for improving health-related quality of life for people living with HIV [ 45 ]. In addition, a different review reported that there were large effects on depression improvement in people living with HIV with an aerobic exercise intervention, three or more times per week, supervised by a professional [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

Noh

2022

IJERPH

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There is a lack of evidence regarding the effects of exercise on older individuals living with HIV. This systematic review and meta-analysis examined previous studies on physical activity interventions for people living with HIV aged ≥50 years. The effectiveness of the interventions on various physical and psychological health outcomes was evaluated. Databases used for this review included PubMed, EMBASE, CINAHL, and Cochrane Library CENTRAL. Twelve randomized controlled trials on physical activity interventions for people ≥50 years and living with HIV were included. Standardized mean differences were calculated using random-effect models. All effect sizes were expressed using Cohen’s d values and their 95% confidence intervals (CIs). Physical activity interventions had a significant effect on walking capacity (Cohen’s d: 0.467; 95% CI [0.069, 0.865]). The effect sizes on cardiorespiratory fitness, weight, and health-related quality of life were not significant. These findings suggest that physical activity interventions for people living with HIV aged ≥50 years are effective for the improvement of walking capacity. Further larger and higher-quality studies are required to determine the full effects of physical activity interventions on various health outcomes among older adults with HIV.

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Section: Discussionmentioning

confidence: 99%

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

Noh

2022

IJERPH

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“…41,42 A more recent meta-analysis found that combined aerobic and resistance training was the most effective exercise intervention to improve cardiorespiratory fitness and health-related quality of life. 43 In addition, Ghayomzadeh et al found that combined training in PLWH increased muscle mass, reduced circulatory levels of pro-inflammatory cytokines and improve muscle function. 3 Additionally, there were a number of par-ticipants with pre-sarcopenic conditions in the combined training group where this condition was reversed while no change occurred in the control group.…”

Section: Sarcopenia Reducing Factorsmentioning

confidence: 99%

A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus

SeyedAlinaghi

Ghayomzadeh

Mirzapour

et al. 2023

J cachexia sarcopenia muscle

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People living with human immunodeficiency virus (HIV) (PLWH) appear to be at an increased risk of sarcopenia, which can have a devastating effect on their life due to consequences such as physical disability, poor quality of life, and finally death. This systematic review examined sarcopenia prevalence and its associated factors in PLWH. A systematic search was conducted using the keywords in the online databases including Scopus, PubMed, Web of Science, Embase and Cochrane databases from the dates of inception up to May 2022. The retrieved articles underwent a two-step title/abstract and full-text review process, and the eligible papers were selected and included in the qualitative synthesis. Data relating to the study population, purpose of study, gender, age, race, body mass index, medical history, paraclinical results and antiretroviral therapy as associated factors of sarcopenia were extracted. In addition, the prevalence of sarcopenia in PLWH and its promoting and reducing factors were also extracted. We reviewed the 14 related studies for identifying of sarcopenia prevalence and its associated factors in PLWH. The total number of PLWH in all the reviewed studies was 2592. There was no criterion for the minimum number of people with HIV and the lowest number of PLWH was 27, and the highest number was 860. Some studies reported a significantly higher prevalence of sarcopenia in HIV-infected individuals compared with HIV-negative controls as follows: 24.2-6.7%, 15-4% and 10-6%, respectively. We showed that, age (30-50 years), being female, >5 years post-HIV diagnosis, multiple vertebral fractures, cocaine/heroin use and lower gamma-glutamyl transferase level were the main promoting factors of sarcopenia. Higher educational level, employment, physical exercise, calf circumference >31 cm, and gait speed >0.8 m/s were also factors to reduce sarcopenia. Sarcopenia prevalence in PLWH is higher than HIV-negative population. Given the importance and prevalence of sarcopenia among PLWH and its associated consequences (i.e., mortality and disability), determining its risk factors is of great importance.

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“…In our study, we addressed the need of incorporating PA in the comprehensive care provided to PLH and the challenges for its effectiveness from the perspective of patients followed up at a university HIV outpatient clinic in the city of São Paulo, Brazil. Our option to evaluate this relevant issue among PLH starting ART without body changes and metabolic abnormalities was due to the fact the PA has already been well recognized as useful to treat these longterm adverse effects of chronic HIV infection and ART [7][8][9][10][11][12][13]26]. In contrast, our main interest was to understand to what extent promotion of PA could benefit individuals at early stages of HIV infection and what services could do to maximize intervention uptake.…”

Section: Plos Onementioning

confidence: 99%

“…In fact, there is evidence that combined resistance and aerobic training improve body composition, increase muscular strength, and reduce blood cholesterol of PLH [7][8][9]. In addition, training leads to increased cardiorespiratory fitness and flexibility of these patients [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Incorporating physical activity in the comprehensive care of people living with HIV starting antiretroviral therapy: Insights from a specialized care setting in São Paulo, Brazil

Santos

Picone

et al. 2021

PLoS ONE

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Background Managing HIV infection as a chronic condition includes encouraging adoption of healthy behaviors and promotion of physical activity (PA). However, people living with HIV (PLH) are often under social and programmatic vulnerability that may compromise behavior change. Understanding such barriers is crucial for successful incorporation of PA in their comprehensive care. Methods and findings In this study, we describe PA, energy intake from diet, and anthropometry of a cohort of PLH starting antiretroviral therapy (ART) at a Brazilian reference clinic, report how PA was addressed in routine care and investigate association between PA, energy intake and psychosocial constructs that may facilitate PA (social support and self-efficacy for PA). Among 61 PLH (86.9% males, mean age = 32.5 years) anthropometry was normal, but 47.5% reported PA below recommendations. Despite presenting high social support scores, family encouragement for PA was low, and self-efficacy classified as medium. Chart reviews yielded infrequent reports concerning PA. After adjusting for gender and age, we found a negative association between energy intake from diet and self-efficacy, but none between PA and energy intake or between PA and psychosocial constructs. Conclusions We conclude that patients in our cohort were insufficiently active when starting ART, and that PA was poorly addressed by caretakers in routine HIV care. Nevertheless, social support and self-efficacy scores suggest potential for behavioral change. Caregivers should therefore start considering patients’ vulnerabilities and establishing strategies to help them overcome barriers to incorporate PA in their comprehensive care effectively.

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Effects of Exercise Interventions on Aerobic Capacity and Health-Related Quality of Life in People Living With HIV/AIDS: Systematic Review and Network Meta-Analysis

Cited by 13 publications

References 65 publications

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

Effects of Physical Activity Interventions on Health Outcomes among Older Adults Living with HIV: A Systematic Review and Meta-Analysis

A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus

Incorporating physical activity in the comprehensive care of people living with HIV starting antiretroviral therapy: Insights from a specialized care setting in São Paulo, Brazil

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