Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review

Li, Tong; Han, Xiao; Chen, Shiqi; Wang, Baofu; Teng, Yuou; Cheng, Weiting; Lu, Ziwen; Li, Yang; Wu, Xiaoxiao; Jiang, Yangyang; Wang, Lei; Liu, Lisong; Zhao, Mingjing

doi:10.1007/s12265-022-10282-5

Cited by 4 publications

(3 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, a randomized prospective exercise trial we conducted comparing interval to continuous exercise for 2‐weeks in older adults who had prediabetes showed divergent responses, whereby interval exercise lowered, but continuous exercise increased, EVs in direct relation to gains in VO 2 max (Eichner et al, 2020 ). This observation is somewhat consistent with prior exercise work suggesting EVs increase in the immediate post‐exercise period, which was suggested to favor angiogenesis (Li et al, 2022 ; Nederveen et al, 2021 ; Siqueira et al, 2021 ; Vechetti et al, 2021 ). While this prior work has focused on exercise, less data are available testing roles of physical activity and/or sedentary behavior.…”

Section: Discussionsupporting

confidence: 88%

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

Ragland

Heiston

Ballantyne

et al. 2023

Physiological Reports

View full text Add to dashboard Cite

Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of insulin on EVs in relation to vascular function. Adults with MetS ( n = 51, n = 9 M, 54.8 ± 1.0 years, 36.4 ± 0.7 kg/m 2 , ATPIII: 3.5 ± 0.1 a.u., VO 2 max: 22.1 ± 0.6 ml/kg/min) were enrolled in this cross‐sectional study. Peripheral insulin sensitivity (M‐value) was determined during a euglycemic clamp (40 mU/m 2 /min, 90 mg/dl), and blood was collected for EVs (CD105+, CD45+, CD41+, TX+, and CD31+; spectral flow cytometry), inflammation, insulin, and substrates. Central hemodynamics (applanation tonometry) was determined at 0 and 120 min via aortic waveforms. Pressure myography was used to assess insulin‐induced arterial vasodilation from mouse 3rd order mesenteric arteries (100–200 μm in diameter) at 0.2, 2 and 20 nM of insulin with EVs from healthy and MetS adults. Adults with MetS had low peripheral insulin sensitivity (2.6 ± 0.2 mg/kg/min) and high HOMA‐IR (4.7 ± 0.4 a.u.) plus Adipose‐IR (13.0 ± 1.3 a.u.). Insulin decreased total/particle counts ( p < 0.001), CD45+ EVs ( p = 0.002), AIx75 ( p = 0.005) and Pb ( p = 0.04), FFA ( p < 0.001), total adiponectin ( p = 0.006), ICAM ( p = 0.002), and VCAM ( p = 0.03). Higher M‐value related to lower fasted total EVs ( r = −0.40, p = 0.004) while higher Adipose‐IR associated with higher fasted EVs ( r = 0.42, p = 0.004) independent of VAT. Fasting CD105+ and CD45+ derived total EVs correlated with fasting AIx75 ( r = 0.29, p < 0.05) and Pb ( r = 0.30, p < 0.05). EVs from MetS participants blunted insulin‐induced vasodilation in mesenteric arteries compared with increases from healthy controls across insulin doses (all p < 0.005). These data highlight EVs as potentially novel mediators of vascular insulin sensitivity and disease risk.

show abstract

Section: Discussionsupporting

confidence: 88%

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

Ragland

Heiston

Ballantyne

et al. 2023

Physiological Reports

View full text Add to dashboard Cite

show abstract

“…These EVs may play an important role in modulating the immune responses and cellular crosstalk following exercise. 51,52 Furthermore, viral triggers, which may cause URTIs, were demonstrated to significantly alter the cargo composition of airway epithelial cell-derived EVs, resulting in elevated inflammatory cytokine production. 53,54 Although EV research is still nascent and data from human studies are scarce, Fig.…”

Section: Discussionmentioning

confidence: 99%

Association of low physical activity with higher respiratory tract infections frequency among pre-school children

Ostrzyżek-Przeździecka

Pańczyk

Bronikowski

et al. 2023

Pediatr Res

View full text Add to dashboard Cite

BACKGROUND: There is no consensus on the benefits of physical activity (PA) regarding upper respiratory tract infections (URTIs) among children. This study aimed to determine an association between the PA level and URTIs in preschoolers. METHODS: In 4-7-year-old participants, URTI symptoms were monitored using the Polish version of the Wisconsin Upper Respiratory System Survey for Kids. The daily number of steps, PA intensity, and sleep duration were measured with a Garminvivofit pedometer. The lag effect between the initial level of daily PA and the frequency of infections was evaluated. RESULTS: The average daily step count from healthy days was a significant determinant of the total number of days with the URTI symptoms, and it accounted for 44% (p < 0.001) of this variable variance. A low level of baseline PA (initial 14-day "run-in" observation period) was associated with an increased risk of URTI. In the non-sport group, the severity of the URTI symptoms depended on the number of daily steps. No significant correlation was found between sleep duration and the number of URTI days. CONCLUSION: Low levels of PA in preschoolers result in increased susceptibility to respiratory infections. Parents should encourage children to engage in PA to prevent URTIs.

show abstract

“…Multiple tissues release EVs following exercise ( D’Souza et al, 2018 ), and exercise can up-regulate p-y-IRS ( Heled et al, 2003 ; Wrann et al, 2013 ). Recent studies have demonstrated a significant increase in the amount of EVs during exercise, which restores to pre-exercise level after 4 h. Moreover, EVs induced by exercise tend to be transported to the liver ( Whitham et al, 2018 ; Li et al, 2022 ). Insulin resistance in the liver is a critical inducement of T2DM ( Perry et al, 2014 ), and pharmacological intervention of glucose metabolism in the liver is an important treatment strategy for T2DM ( Lin et al, 2000 ; Shaw et al, 2005 ).…”

Section: The Transmission Of Insulin Resistance Can Be Prevented By A...mentioning

confidence: 99%

Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases

Li²,

Liu³

et al. 2023

Front. Mol. Biosci.

View full text Add to dashboard Cite

Noncommunicable diseases (NCDs), such as diabetes and related neurological disorders, are considered to not be directly transmissible from one person to another. However, NCDs may be transmissible in vivo through extracellular vesicles (EVs). A long-term high-fat diet (HFD) can induce a series of health issues like hyperlipidemia, type 2 diabetes mellitus (T2DM), and diabetic peripheral neuropathy (DPN) due to insulin resistance. Multiple molecular signaling changes can stimulate insulin resistance, especially blocking insulin signaling by increased insulin resistance inducer (phosphorylation of negative regulatory sites of insulin receptor substrate (IRS) proteins) and decreased tyrosine phosphorylation of insulin receptor substrate (phosphorylation of positive regulatory sites of IRS), thus leading to reduced phosphorylation of AKT enzymes. Current efforts to treat T2DM and prevent its complications mainly focus on improving insulin sensitivity, enhancing insulin secretion, or supplementing exogenous insulin based on a common assumption that insulin resistance is noncommunicable. However, insulin resistance is transmissible within multiple tissues or organs throughout the body. Exploring the regulatory roles of EVs in developing insulin resistance may provide novel and effective preventive and therapeutic strategies.

show abstract

Effects of Exercise on Extracellular Vesicles in Patients with Metabolic Dysfunction: a Systematic Review

Cited by 4 publications

References 106 publications

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

Association of low physical activity with higher respiratory tract infections frequency among pre-school children

Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases

Contact Info

Product

Resources

About