Effects of exercise training and resveratrol on vascular health in aging

Bio‐Inspired Cryo‐Ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification

“…The intracellular NO and ROS levels as regulators for blood flow and RBC homeostasis were also evaluated . NO is a crucial short‐lived signaling molecule regulating local vasodilation .…”

How efficient is resveratrol as an antioxidant of the Mediterranean diet, towards alterations during the aging process?

“…The beneficial effects of RSV associated with the practice of physical exercise are not clear either. Although there is some evidence of beneficial effects, RSV counteracts its positive effects [20]. At the opposite, supplementation with RSV augmented the improvement of mitochondrial function, muscle fatigue resistance, and the increased mean fibre area and muscle nuclei associated with exercise, which may contribute to reducing/reversing sarcopenia in elderly people [21].…”

“…The beneficial effects of RSV associated with the practice of physical exercise are not clear either. Although there is some evidence of beneficial effects, RSV as an antioxidant can affect the same pathways induced by physical exercise and counteract its positive effects [20]. The effects of RSV (500 mg/day) combined with 12 weeks of regular aerobic exercise were investigated in 65-80-year-old subjects [21].…”

Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets

“…non‐steroid anti‐inflammatory drugs (NSAIDs), sulfhydrated ACE inhibitors (ACEi) and PDE5) may mediate part of their effects through H 2 S and, furthermore, some drugs like atorvastatin specifically increase PVAT‐derived H 2 S (Beltowski, ), corroborating H 2 S's therapeutic potential. On the other hand, the sulfide prodrug resveratrol has only displayed limited cardiovascular benefit in clinical studies (Gliemann et al , ), implying that its effects may depend upon the underlying disease state or pharmacokinetic limitations. As such, further research into modulating AT‐derived H 2 S provides an exciting avenue to explore novel pharmacological targets against vascular disease pathogenesis (Figure ).…”