Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review

Negaresh, Raoof; Motl, Robert W.; Mokhtarzade, Motahare; Dalgas, Ulrik; Patel, Darpan I.; Shamsi, Mahdieh Molanouri; Majdinasab, Nastaran; Ranjbar, R; Zimmer, Philipp; Baker, Julien S.

doi:10.1016/j.msard.2018.06.008

Cited by 45 publications

(57 citation statements)

References 62 publications

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“…Based on the PEDro scale, this study had the highest methodological quality (9/10). However, this study did not satisfy the fifth PEDro criterion (blinding all subjects); this criterion is not applicable for exercise training intervention studies . Other research confirms that resting serum levels of MMP‐9 remain stable after combined training; however, this study had >15% drop‐out of participants, which undermined the results.…”

Section: Discussionmentioning

confidence: 70%

“…Moreover, brain volume showed a trend, which was not significant, towards a reduced rate of brain atrophy during supervised exercise training. Our recent systematic review concluded that exercise training (i.e. resistance training) can reduce pro‐inflammatory cytokine levels, which can lead to reduced brain atrophy and lesion development.…”

Section: Discussionmentioning

confidence: 99%

“…In this randomized controlled trial, only s100 calcium‐binding protein B demonstrated significant change in the normal‐weight group who exercised. As exercise training is able to reduce reactive oxygen species and pro‐inflammatory cytokines , physical activity can be considered as a strategy to reduce BBB permeability and to improve integrity. A study that examined MMP‐2 and MMP‐9 as BBB indicators showed significant reductions in the serum level of MMP‐2, but not MMP‐9, after high‐intensity interval training.…”

Section: Discussionmentioning

confidence: 99%

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Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

Negaresh

Motl

Zimmer

et al. 2019

Euro J of Neurology

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Background and purpose Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central nervous system (CNS) that can be tracked through biomarkers of disease status. We investigated the effects of exercise on MS biomarkers associated with CNS status including imaging, blood–brain barrier (BBB) function and neurotrophic factors. Methods We conducted open‐dated searches of Scopus, Medline, EMBASE and the Cochrane Library. We included studies written in English describing interventions of exercise that measured one or more of the biomarkers associated with MS published up to October 2018. Results We located a total of 3012 citations through searches in electronic databases. Of these, 16 studies were eligible for review; six studies focused on magnetic resonance imaging (MRI) markers, nine studies focused on neurotrophic factors and three studies focused on BBB function markers. It is of note that two studies included both neurotrophic factor and BBB function markers and are therefore included across categories of biomarkers in this review. The existing evidence from MRI studies confirmed that exercise training can improve CNS integrity and function. There is evidence of a positive effect of exercise training on modulation of BBB permeability markers and brain‐derived neurotrophic factor. Conclusions Exercise successfully improves MRI outcomes and peripheral biomarkers (i.e. brain‐derived neurotrophic factor) in people with MS. This suggests that exercise can be recommended as an adjuvant therapy for MS treatment. This conclusion is tempered by some methodological limitations including small sample sizes and high drop‐out rates in the reviewed studies.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

Negaresh

Motl

Zimmer

et al. 2019

Euro J of Neurology

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“…The vast majority of human studies look primarily at the peripheral effects of exercise in MS patients including serum and plasma cytokine concentrations (reviewed in Heesen, Romberg, Gold, & Schulz, 2006;Negaresh et al, 2018). There is evidence that exercise can reduce the permeability of the blood-brain barrier (BBB) which would indicate that exercise may result in exclusion of immune cells from the CNS (Schön et al, 2019;Souza et al, 2017).…”

Section: Human Studies Of Cns Neuroinflammationmentioning

confidence: 99%

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes

Guo

Lozinski

Yong

2019

J of Neuroscience Research

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Multiple sclerosis (MS) is a central nervous system (CNS) disorder characterized by inflammation, demyelination, and neurodegeneration. Emerging research suggests that exercise has therapeutic benefits for MS patients but the clinical data have focused primarily on non‐CNS outcomes. In this review, we discuss evidence in preclinical MS models that exercise influences oligodendrocyte proliferation and repopulation, remyelination, neuroinflammation, neuroprotection, axonal regeneration, and astrogliosis. Evidence for the therapeutic effects of exercise in MS is further supplemented by data from other CNS diseases, including Alzheimer's disease, Parkinson's disease, and spinal cord injury. These results motivate studies into the benefits that exercise confers within the CNS in MS.

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“…The controlling of mass and phenotype fatty tissue is an effective approach to regulate adipokines and their underlying pathways (Figure 1). Our recent review observed that research regarding the effects of exercise training on adipokines and cytokines in pwMS is in its infancy (51). We are aware of only three original investigations that studied the effects of exercise intervention on adipokines in pwMS.…”

Section: Immune and Adipokine Markersmentioning

confidence: 99%

Weight control and physical exercise in people with multiple sclerosis: Current knowledge and future perspectives

Mokhtarzade

Alinejad

Motl

et al. 2019

Complementary Therapies in Medicine

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Highlights 3 weight loss in people MS is needed. The most comprehensive weight management guidelines are outlined in the American College of Sports Medicine Position Statement, which recommends between 150-250 minutes per week of moderate-intensity physical activity for preventing weight gain, and between 225-420 minutes per week of moderate-intensity physical activity for weight loss. These recommendations seem applicable for people with multiple sclerosis.

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Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review

Abstract: Research regarding the effects of exercise training on cytokines and adipokines in MS is in its infancy, but exercise represents an adjuvant therapy in MS, and future studies are essential for clarifying the role of exercise on cytokines and adipokines in MS.

Cited by 45 publications

References 62 publications

Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

Effects of exercise training on multiple sclerosis biomarkers of central nervous system and disease status: a systematic review of intervention studies

Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes

Weight control and physical exercise in people with multiple sclerosis: Current knowledge and future perspectives

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