Effects of Exercise upon Immunoregulation: Facts and a Modern View of its Molecular Mechanisms

Valencia-Sánchez, Salvador; Drucker-Colı́n, René; Collazo-Navarrete, Omar; Prospéro-Garcı́a, Oscar; Morales‐Montor, Jorge

doi:10.3233/nib-190161

Cited by 1 publication

(2 citation statements)

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“…Consequently, comparative literature is sparse. In general, physical exercise that involves repetitive muscle contraction acutely stimulates the activity of the central nervous system and causes systemic substrate metabolism (Valencia-Sánchez et al 2019 ). This would alter immune cell activity/function and further, stimulate the release of glucocorticoid hormones (e.g., cortisol), catecholamines (e.g., adrenaline), cytokines (e.g., Interleukin-6), and WBC into peripheral circulation (Valencia-Sánchez et al 2019 ; Rosa-Neto et al 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…In general, physical exercise that involves repetitive muscle contraction acutely stimulates the activity of the central nervous system and causes systemic substrate metabolism (Valencia-Sánchez et al 2019 ). This would alter immune cell activity/function and further, stimulate the release of glucocorticoid hormones (e.g., cortisol), catecholamines (e.g., adrenaline), cytokines (e.g., Interleukin-6), and WBC into peripheral circulation (Valencia-Sánchez et al 2019 ; Rosa-Neto et al 2022 ). Thereby, the increase in WBC seems to be due to demargination from the vessel walls and to cell releases from organic storage (e.g., liver, lung), as well as the thymus gland, bone marrow lymph nodes, and skeletal muscle (Simpson et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

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Acute effects of concurrent muscle power and sport-specific endurance exercises on markers of immunological stress response and measures of muscular fitness in highly trained youth male athletes

et al. 2023

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Purpose To examine the acute effects of concurrent muscle power and sport-specific endurance exercises order on immunological stress responses, muscular-fitness, and rating-of-perceived-exertion (RPE) in highly trained youth male judo athletes. Methods Twenty male participants randomly performed two concurrent training (CT) sessions; power-endurance and endurance-power. Measures of immune response (e.g., white blood cells), muscular-fitness (i.e., counter-movement-jump [CMJ]), RPE, blood-lactate, and -glucose were taken at different time-point (i.e., pre, mid, post, and post6h). Results There were significant time*order interactions for white blood cells, lymphocytes, granulocytes, granulocyte-lymphocyte-ratio, and systemic-inflammation-index. Power-endurance resulted in significantly larger pre-to-post increases in white blood cells and lymphocytes while endurance-power resulted in significantly larger pre-to-post increases in the granulocyte-lymphocyte-ratio and systemic-inflammation-index. Likewise, significantly larger pre-to-post6h white blood cells and granulocytes increases were observed following power-endurance compared to endurance-power. Moreover, there was a significant time*order interaction for blood-glucose and -lactate. Following endurance-power, blood-lactate and -glucose increased from pre-to-mid but not from pre-to-post. Meanwhile, in power-endurance blood-lactate and -glucose increased from pre-to-post but not from pre-to-mid. A significant time*order interaction was observed for CMJ-force with larger pre-to-post decreases in endurance-power compared to power-endurance. Further, CMJ-power showed larger pre-to-mid performance decreases following power-endurance, compared to endurance-power. Regarding RPE, significant time*order interactions were noted with larger pre-to-mid values following endurance-power and larger pre-to-post values following power-endurance. Conclusion CT induced acute and delayed order-dependent immune cell count alterations in highly trained youth male judo athletes. In general, power-endurance induced higher acute and delayed immunological stress responses compared to endurance-power. CMJ-force and RPE fluctuated during both CT sessions but went back to baseline 6 h post-exercise.

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Section: Discussionmentioning

confidence: 99%