Effects of exogenous recombinant human granulocyte colony-stimulating factor (filgrastim, rhG-CSF) on neutrophils of critically ill patients with systemic inflammatory response syndrome depend on endogenous G-CSF plasma concentrations on admission

Weiß, Manfred; Voglic, Sami J.; Harms-Schirra, Britt; Lorenz, I.; Lasch, Britta; Dumon, Kristoffel R.; Groß-Weege, W.; Schneider, E. M.

doi:10.1007/s00134-003-1734-y

Cited by 14 publications

(6 citation statements)

References 41 publications

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“…The use of granulocyte colony stimulating factor has also been used in patients with severe neutropenia. 22 A separate study from our institution which analyzed the survival outcomes of 106 patients with pseudomyxoma peritonei showed that severe morbidity has an adverse impact on survival. 23 The importance of this association must remind surgeons that a poor perioperative outcome, even if full recovery is established, may not translate to eventual long-term survival and that this can be rectified by being mindful of the associated risk factors.…”

Section: Discussionmentioning

confidence: 99%

Morbidity and Mortality Outcomes of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy at a Single Tertiary Institution

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Morbidity and Mortality Outcomes of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy at a Single Tertiary Institution

et al. 2010

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“…Knowing that age and gender have influence on immune functions, due to our limited possibilities we have included in our studies all patients with multiple trauma with ISS >15 and all patients with acute pancreatitis fulfilling the above exclusion criteria, regardless to age and gender (11,25,(27)(28)(29)(30)(31).…”

Section: Subject Selectionmentioning

confidence: 99%

Self-regulation of neutrophils during phagocytosis is modified after severe tissue injury

Pap¹,

Fűrész

Fennt

et al. 2006

Int J Mol Med

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Neutrophil (PMNL) function is influenced by factors released by other immune cells during the course of the immune response. We investigated the effect of neutrophil cell density and the effect of supernatant of the phagocytosis assay on the phagocytosis activity of PMNLs. The measurements were carried out with naive (control) PMNLs of healthy donors and with PMNLs obtained from patients with severe tissue injury. Phagocytosis index (FI) of PMNLs was determined at cell densities of 7.5x10 5 /ml and 15x10 5 /ml. E. coli phagocytosis of heparinized whole blood from healthy donors and patients with severe tissue injury was measured and evaluated at three different cell densities (normal, half, and double densities) by flow cytometry. Supernatants of phagocytosis assays of either control or trauma (ISS >18) patient PMNLs were added to the assay suspensions of control and trauma PMNLs. An increase in cell density of healthy donor PMNLs increased yeast phagocytic activity. In cases of tissue injury, PMNLs showed increased phagocytic activity at lower cell densities. E. coli phagocytosis was increased with the increase of cell density, and tissue injury PMNLs were more active at each cell concentration compared to naive cells. Polytrauma supernatants in most cases inhibited, while healthy supernatants mostly increased the yeast phagocytosis of healthy and trauma PMNLs. These results reinforce the idea that primed PMNLs in the presence of microbial agents produce factor(s) which inhibit some of the cell's antimicrobial functions contributing to immunedysfunction, while unprimed PMNLs produce factor(s) which facilitate antimicrobial countermeasure. These results also demonstrate that reduced phagocytosis of tissue injury primed PMNLs is not due to cytoskeletal changes but to the humoral environment.

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“…4 G-CSF may also block the hyperinflammatory cytokine cascade mediated by inflammatory cytokines, such as tumor necrosis factor (TNF) and interleukin 1, before severe tissue damage occurs. 5 The timing of G-CSF administration may also affect patient outcomes. Unresolved infections may precipitate and drive the systemic inflammatory response, potentially resulting in multiple organ failure (MOF) and septic shock.…”

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Use of granulocyte colony-stimulating factor in patients with severe sepsis or septic shock

Mohammad

2010

American Journal of Health-System Pharmacy

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The available data, especially those from large, prospective, randomized, double-blind studies, do not support the use of G-CSF as an adjunct therapy to standard care for critically ill patients with severe sepsis or septic shock. Data from prospective, large, randomized, controlled, well-designed studies are needed to define the optimal G-CSF dosing regimen, the safety of this therapy, and the effects of G-CSF on patient morbidity and survival.

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Effects of exogenous recombinant human granulocyte colony-stimulating factor (filgrastim, rhG-CSF) on neutrophils of critically ill patients with systemic inflammatory response syndrome depend on endogenous G-CSF plasma concentrations on admission

Abstract: Besides activation of neutrophil maturation, low-dose rhG-CSF application in postoperative patients with SIRS has different effects on neutrophil functions, in part depending on already endogenously produced G-CSF.

Cited by 14 publications

References 41 publications

Morbidity and Mortality Outcomes of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy at a Single Tertiary Institution

Morbidity and Mortality Outcomes of Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy at a Single Tertiary Institution

Self-regulation of neutrophils during phagocytosis is modified after severe tissue injury

Use of granulocyte colony-stimulating factor in patients with severe sepsis or septic shock

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