Effects of experimental pastes containing surface pre-reacted glass ionomer fillers on inhibition of enamel demineralization

Nakamura, Keiki; Hamba, Hidenori; Nakashima, Shinsuke; Sadr, Alireza; Nikaido, Toru; Oikawa, Masakazu; Uo, Motohiro; Tagami, Junji

doi:10.4012/dmj.2016-303

Cited by 20 publications

(21 citation statements)

References 39 publications

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“…In addition, nearly one-third of the final concentration of Sr (i.e., 2,880 ppm) was incorporated after 1 h of immersion. Fast Sr absorption was previously reported by Nakamura et al 14) ; in that report, slight Sr adsorption occurred on the bulk enamel surface after less than 1 h of contact with an S-PRG containing experimental toothpaste. In the present study, Sr ions were supplied in S-PRG filler eluate; enamel powder was used as the test substance; therefore, Sr incorporation occurred more rapidly than in the report by Nakamura et al In addition, rapid incorporation of other ions (e.g., Al and borate) was observed, similar to that of Sr after 1 h of immersion for the S-PRG eluate.…”

Section: Discussionsupporting

confidence: 71%

“…Surface pre-reacted glass-ionomer (S-PRG) fillers release multiple ions (e.g., fluoride, borate, silicate, aluminum, sodium, and strontium) 5) ; various bioactive effects by these released ions have been reported for the suppression of bacterial adhesion [6][7][8][9] , biofilm formation 10,11) , prevention of demineralization [12][13][14] , and enhancement of remineralization 15,16) . As noted above, Sr and F ions are expected to provide a preventive effect with respect to caries.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, Sr was reported to accumulate in the enamel and dentin for 3 months with S-PRG eluate immersion; this accumulated Sr was speculated to incorporated to the Ca site of HAP 19) . By using PIXE, Nakamura et al revealed Sr enrichment on the enamel surface after 40 min of contact with an S-PRG-containing experimental toothpaste 14) ; their report suggested that early Sr incorporation could occur in less than 1 h, and that the acid resistance of enamel was improved. Therefore, the effect of ion incorporation released from S-PRG filler could be expected within a short period.…”

Section: Introductionmentioning

confidence: 99%

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Time dependence of multi-ion absorption into human enamel from surface prereacted glass-ionomer (S-PRG) filler eluate

et al. 2019

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Ion incorporation into the tooth is expected to be effective for caries prevention. Time-dependent ion incorporation released from surface pre-reacted glass-ionomer (S-PRG) filler eluate into tooth enamel was estimated by using inductively coupled plasma atomic emission spectroscopy (ICP-AES). Al, B, and Sr contents in enamel were increased in a time-dependent manner with immersion in S-PRG eluate. Clear ion incorporation was observed after 1 h of immersion in S-PRG filler eluate. Sr showed remarkable incorporation in enamel-up to 7,900 ppm-after 28 days of immersion. Sr and B incorporation rapidly occurred in S-PRG filler eluate, compared with their single component solutions. Simultaneous incorporation of cations and anions from S-PRG eluate occurred under balanced charge and may assist in rapid ion incorporation. Thus, various useful ions could be effectively incorporated into tooth enamel by applying S-PRG filler or its eluate; a bioactive effect can be expected.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Time dependence of multi-ion absorption into human enamel from surface prereacted glass-ionomer (S-PRG) filler eluate

et al. 2019

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“…FL‐BF is a multi‐ion releasing adhesive/composite restoration formed from FL‐Bond II and Beautifil Flow F10. Both FL‐Bond II and Beautifil Flow F10 contain S‐PRG fillers, which have a potential to release multi‐ions, such as F − , Al 3+ ,

{BO}_{3}^{3 -}

, Na + ,

{SiO}_{3}^{2 -}

SiO 3 2− , and Sr 2+ and to inhibit demineralization . It has been reported that the S‐PRG filler exerts a strong buffering capacity, bringing the pH value of the surrounding environment to a weak alkaline range when it comes into contact with water or acidic solution .…”

Section: Discussionmentioning

confidence: 99%

Micro‐computed tomography assessment of root dentin around fluoride‐releasing restorations after demineralization/remineralization

Zan

Nakamura

Hamba

et al. 2018

European J Oral Sciences

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Using micro-computed tomography (micro-CT), this study assessed the inhibitory effect of three different types of restorations on root-caries formation under a cariogenic challenge. Bovine-root dentin blocks with a cylindrical cavity were divided into three restoration groups: a fluoride-free self-etch adhesive and a resin composite (SE-ES); a self-etch adhesive and a resin composite with multi-ion release (FL-BF); and a glass ionomer cement (Fuji-VII). After the restorative procedures, the specimens were stored in artificial saliva for 1 d, then subjected to a demineralization solution for 4 d and a remineralization solution for 28 d. Mineral density and mean mineral loss of dentin around the restorations were measured using micro-CT. The mean mineral loss values of dentin around the restorations were highest among SE-ES restorations and lowest among Fuji-VII restorations. Fuji-VII showed the highest mineral density and the lowest mineral loss after 28 d of remineralization. The observations made by scanning electron microscopy demonstrated that Fuji-VII created the smallest outer lesion followed by FL-BF and SE-ES. Fuji-VII has a larger inhibitory effect on root caries around the restorations and enhances remineralization more effectively than either FL-BF or SE-ES. Multi-ion and fluoride release from the restorative materials may be beneficial for inhibition of root-dentin caries around the restorations.

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“…Specimens were then immersed in 125 mL of a buffered demineralizing solution containing 2.2 mmol/L CaCl 2, 2.2 mmol/L NaH2PO4, and 50 mmol/L acetic acid adjusted to pH 4.5 22) , then removed from the solution after 7 days demineralization, rinsed, after which µCT scanning was performed (Fig. 1).…”

Section: Specimen Preparationmentioning

confidence: 99%

Micro-CT assessment of the effect of silver diammine fluoride on inhibition of root dentin demineralization

et al. 2021

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This study evaluated the ability of different types of silver diammine fluoride (SDF) to inhibit dentin demineralization using microfocused X-ray computed-tomography (µCT). Dentin specimens were divided into five groups (n=10); no-treatment (control), 3.8% SDF (RC), 38% SDF, 38% SDF with potassium iodide (SDF/KI), and potassium fluoride (KF). The treated-dentin surfaces were subjected to demineralization for 7-days and assessed using µCT to determine mineral loss (ML) values. Specimens were also analyzed with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The ML values of the SDF and KF groups were significantly lower than those of the RC and SDF/KI groups. EDS detected fluoride ions in the SDF and KF groups but not in the RC and SDF/KI groups. It was concluded that 38% SDF demonstrated a high ability to inhibit dentin demineralization while additional application of KI may diminish the inhibitory effect of SDF. The amount of dentin demineralization with SDF treatments was material dependent.

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Effects of experimental pastes containing surface pre-reacted glass ionomer fillers on inhibition of enamel demineralization

Cited by 20 publications

References 39 publications

Time dependence of multi-ion absorption into human enamel from surface prereacted glass-ionomer (S-PRG) filler eluate

Time dependence of multi-ion absorption into human enamel from surface prereacted glass-ionomer (S-PRG) filler eluate

Micro‐computed tomography assessment of root dentin around fluoride‐releasing restorations after demineralization/remineralization

Micro-CT assessment of the effect of silver diammine fluoride on inhibition of root dentin demineralization

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