Effects of Exposure of CHO-K1 Cells to a 10-T Static Magnetic Field

Nakahara, Toro; Yaguchi, Hiroko; Yoshida, Masami; Miyakoshi, Junji

doi:10.1148/radiol.2243011300

Cited by 112 publications

(85 citation statements)

References 21 publications

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“…Long-term exposure to a static magnetic field alone did not affect micronucleus formation [2]. In X-ray-irradiated cells, exposure to a 1-T static magnetic field also did not affect micronucleus formation, but exposure to a 10-T static magnetic field resulted in a significant (p!0.05) increase in micronucleus formation induced after a 4-Gy exposure.…”

Section: Micronucleus Formationmentioning

confidence: 80%

“…Clonogenic activity, DNA synthesis, cell cycle, and proliferation kinetics were not altered by exposure to the magnetic field and repetitive exposure to a static magnetic field up to 10 T exerted no effects on proliferation of human fetal lung fibroblast cells [1,2]. Cell cycle analysis of synchronized and nonsynchronized human fetal lung fibroblasts (HFLFs) cells did not reveal statistically significant differences between the cells exposed to 0.2, 1.0, or 1.5 T for 1 h/day for 5 consecutive days and control cells [3].…”

Section: Cell Proliferation and Cell Cycle Distributionmentioning

confidence: 95%

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The review of cellular effects of a static magnetic field

Miyakoshi

2006

Science and Technology of Advanced Materials

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The effects of static magnetic fields at the cellular level are reviewed. Past studies have shown that a static magnetic field alone does not have a lethal effect on the basic properties of cell growth and survival under normal culture conditions, regardless of its magnetic density. It has also been shown that cell cycle distribution is not influenced by extremely strong static magnetic fields (up to a maximum of 10 tesla (T)). A further area of interest is whether static magnetic fields cause DNA damage, which can be evaluated by determination of the frequency of micronucleus formation. The presence or absence of such micronuclei can confirm whether a particular treatment damages cellular DNA. This method has been used to confirm that a static magnetic field alone has no such effect. However, the frequency of micronucleus formation changes significantly when certain treatments (for example, X-irradiation and mitomycin C) are given during exposure to a strong static magnetic field. It has also been reported that treatment with trace amounts of ferrous ions in the cell culture medium and exposure to a static magnetic field increases DNA damage, which is detected using the comet assay. Several reports suggest that a strong static magnetic field may affect the ion transport and the gene expression. In addition, many studies have found a strong magnetic field can induce orientation phenomena in cell culture. q

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Section: Micronucleus Formationmentioning

confidence: 80%

Section: Cell Proliferation and Cell Cycle Distributionmentioning

confidence: 95%

The review of cellular effects of a static magnetic field

Miyakoshi

2006

Science and Technology of Advanced Materials

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“…We also found no toxic effect on the ADSCs in this study. There may be concern that a high magnetic field can cause damage to the human body; however, reports indicated that static EMF from 0.3 T up to 1 T for more than 8 h/day did not have deleterious effects (25,(27)(28)(29). Even though the World Health Organization is concerned about the in vivo and in vitro effects of high EMF of more than 1 T, there is no definite evidence that high EMF will lead to damage in vivo and in vitro (30,31).…”

Section: Discussionmentioning

confidence: 99%

Electromagnetic fields enhance chondrogenesis of human adipose-derived stem cells in a chondrogenic microenvironment in vitro

Lin

et al. 2013

Journal of Applied Physiology

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“…SMFs alone do not have a lethal effect on the basic properties of cell growth and survival under normal culture conditions (Nakahara et al, 2002;Sakurai et al, 2009). Most studies have also suggested that SMFs do not affect cell proliferation (Hiraoka et al, 1992) or influence the cell cycle.…”

Section: Introductionmentioning

confidence: 99%