Effects of exposure to high levels of particulate air pollution during the follicular phase of the conception cycle on pregnancy outcome in couples undergoing in vitro fertilization and embryo transfer

Perin, P.M.; Maluf, Mariângela; Czeresnia, Carlos Eduardo; Januário, Daniela Aparecida Nicolosi Foltran; Saldiva, Paulo Hilário Nascimento

doi:10.1016/j.fertnstert.2009.06.031

Cited by 77 publications

(64 citation statements)

References 12 publications

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“…Most of human data come from retrospective studies, based on declarative answers, predicted/modeled exposure levels and fail to take into account important confounders such as tobacco exposure. However, the only prospective human study based on a large population (36,294 women) and precise geolocalization data, found an impact of the proximity of residential address to major roads on the risk of infertility [32], which corroborates the results from mice studies [27,28].…”

Section: Resultssupporting

confidence: 70%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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Background: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included (1) ovary or follicle or oocyte or testis or testicular or sperm or spermatozoa or fertility or infertility and (2) air quality or O 3 or NO 2 or PM2.5 or diesel or SO 2 or traffic or PM10 or air pollution or air pollutants. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the search terms and published in English. We have excluded articles whose results did not concern fertility or gamete function and those focused on cancer or allergy. We have also excluded genetic, auto-immune or iatrogenic causes of reduced reproduction function from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on fertility and the molecular pathways involved.

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Section: Resultssupporting

confidence: 70%

Does air pollution play a role in infertility?: a systematic review

et al. 2017

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“…The selection of a single pollutant from a complex mixture of compounds present in air pollution to evaluate its effects on IVF/ET treatment and pregnancy outcome may represent another important source of bias since some of the reported effects may be attributed to other pollutants. However, based on the results of our previous studies showing the effects of ambient PM [22] and DEP [21] on fertilization and embryo development in vitro and on cell lineage segregation at the blastocyst stage and of ambient PM on pregnancy outcome in women [24], we focused our study on the evaluation of the possible effects of ambient PM 10 on reproductive health. The lack of difference among the four distinct exposure periods in regard to biochemical early pregnancy loss may be due to the limited number of biochemical pregnancies found in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a retrospective epidemiological study confirmed the increased risk of early pregnancy loss previously observed in experimental studies in women exposed to particulate air pollution. In their study, Perin et al [24] provided evidence for an association between brief exposure to high levels of ambient particulate matter during the preconceptional period and early pregnancy loss, regardless of the method of conception (natural or after IVF treatment), and showed a 2.6-fold increase in the risk of miscarriage.…”

Section: Introductionmentioning

confidence: 98%

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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Purpose To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET. Methods Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q 1 : ≤30.48 µg/m 3 , Q 2 : 30.49-42.00 µg/m 3 , Q 3 : 42.01-56.72 µg/m 3 , and Q 4 : >56.72 µg/m 3 ). Results Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q 4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q 1-3 periods. Conclusion Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.

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“…Perin et al reported that pre-conception exposure to high levels of ambient fine particulate matter (≤10 μM) was associated with a 2.6-fold increase in early pregnancy loss, both in women with natural pregnancy and after IVF [9]. Legro et al studied the air pollution levels based on US Environmental Protection Agency air quality monitors located around the homes and IVF clinics of 7403 women undergoing their first IVF cycles.…”

Section: Introductionmentioning

confidence: 99%

Lack of carbon air filtration impacts early embryo development

Munch

Duran

Voorhis

2015

J Assist Reprod Genet

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Purpose To assess human fertilization and preimplantation embryo development in the presence and in the absence of carbon filtration Methods This is a retrospective cohort analysis of fresh, controlled ovarian hyperstimulation cycles as well as previously cryopreserved pronuclear stage embryo transfer cycles in a single IVF center. Embryo development and cycle-based outcomes were compared among three groups: 1) when carbon filtration was present, 2) when carbon filtration was absent, and 3) when carbon filtration had been restored. Results A total of 524 fresh cycles and 156 cryopreserved embryo cycles were analyzed. Fertilization, cleavage, and blastocyst conversion rates for fresh cycles all declined during the period of absent carbon filtration and recovered after the restoration of carbon filtration. Cryopreserved embryos that were thawed and cultured during the period of absent filtration did not have changes in cleavage or blastocyst conversion rates compared to periods where carbon filtration was present. Clinical pregnancy and live birth rates were unchanged among the three time periods.Conclusions The absence of carbon filtration in an IVF laboratory air handler is associated with poor fertilization and early embryo development for fresh cycles. Because development of previously frozen pronuclear stage embryos was unaffected, the lack of carbon filtration may preferentially affect embryos in the peri-fertilization period. Carbon filtration is an integral part to a successful human in-vitro fertilization laboratory.

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Effects of exposure to high levels of particulate air pollution during the follicular phase of the conception cycle on pregnancy outcome in couples undergoing in vitro fertilization and embryo transfer

Cited by 77 publications

References 12 publications

Does air pollution play a role in infertility?: a systematic review

Does air pollution play a role in infertility?: a systematic review

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Lack of carbon air filtration impacts early embryo development

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