Effects of Extracranial Carotid Stenosis on Intracranial Blood Flow

Hrbac, Tomas; Alaraj, Ali

doi:10.1016/j.jvs.2015.01.019

Cited by 5 publications

(7 citation statements)

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“…However, according to our hypothesis of cerebral damage due to the abnormal cerebral hemodynamics observed in patients with ACS, the existence of patent collaterals would compensate the abnormal hemodynamics and no brain damage should be expected. Also, the cerebral collateral circulation is apparently more important in patients with symptomatic carotid stenosis, which is not the interest of this study (31). Another limitation of our study is the small sample size, which is explained by the fact that ACS is usually an incidental finding.…”

Section: Discussionmentioning

confidence: 95%

Asymptomatic Carotid Stenosis is Associated with Gray and White Matter Damage

Avelar

D’Abreu

Coan

et al. 2015

International Journal of Stroke

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Patients with asymptomatic carotid stenosis have different patterns of gray and white matter abnormalities. While the white matter damage is diffuse, the gray matter atrophy is localized in the territory of anterior circulation ipsilateral to the stenosis. The role of asymptomatic carotid stenosis in the gray matter damage must be further investigated with longitudinal studies and comparison with neuropsychological evaluation.

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Section: Discussionmentioning

confidence: 95%

Asymptomatic Carotid Stenosis is Associated with Gray and White Matter Damage

Avelar

D’Abreu

Coan

et al. 2015

International Journal of Stroke

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“…6,11,22,36 There are several techniques for noninvasive assessment of CBF including CT angiography 11,19 and quantitative MR angiography. [1][2][3]9,13,33,35 New computational methods have been developed to evaluate cortical tran-sit times (TTs) 15,28 However, not all of these methods are available in the angiography suite, and they often require additional radiation or contrast exposure. There are no prior studies that attempted to correlate the angiographic contrast TTs with the neurological exams of patients with aSAH.…”

mentioning

confidence: 99%

Correlation between angiographic transit times and neurological status on admission in patients with aneurysmal subarachnoid hemorrhage

Ivanov¹,

Linninger

Hsu

et al. 2016

JNS

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“…For example, according to the study of Shakur et al, 44 the local hemodynamic effects of internal carotid artery (ICA) stenosis do not translate directly to the distal vasculature. In fact, percentage stenosis and residual lumen were associated with altered flow in the ICA but not in the middle cerebral artery (MCA), presumably because of the presence of collateral pathways in the intracranial circulation.…”

Section: The Vascular and Structural Effectsmentioning

confidence: 99%

“…It is known from the literature that a series of compensatory mechanisms are activated by the cerebrovascular system in order to overcome the cerebral hypoperfusion that is induced by the ECAS, and these mechanisms are mainly sustained by the intracranial circulation. For example, according to the study of Shakur et al, 44 the local hemodynamic effects of internal carotid artery (ICA) stenosis do not translate directly to the distal vasculature. In fact, percentage stenosis and residual lumen were associated with altered flow in the ICA but not in the middle cerebral artery (MCA), presumably because of the presence of collateral pathways in the intracranial circulation.…”

Section: Vascular Imaging Studiesmentioning

confidence: 99%

Extracranial Carotid Artery Stenosis: The Effects on Brain and Cognition with a Focus on Resting‐State Functional Connectivity

Porcu

Cocco

Saloner

et al. 2020

Journal of Neuroimaging

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Extracranial carotid artery stenosis (ECAS) due to the presence of atherosclerotic plaque is a well-known risk factor for stroke. Several structural imaging studies have investigated the effect of ECAS on the brain, focusing on structural damage (in particular cerebral small vessel disease) and on the rearrangement of the cerebral circulation. For example, it is known from the literature an association between carotid stenosis and cerebral small vessel disease, and it is also noted that a series of compensatory mechanisms are activated by the cerebrovascular system in order to overcome the cerebral hypoperfusion that is induced by the ECAS. Several neurocognitive studies have also investigated the association of ECAS with cognitive deficits. While the evidence tends to favor a direct association between ECAS and cognition, the actual relationship remains controversial. In the last decade, various resting-state functional connectivity (rs-fc) magnetic resonance (MR) studies have tried to elucidate the "in vivo" mechanisms underlying the cognitive impairment observed in these patients. Although these studies have been performed on small cohorts of patients without standardized protocols, it is plausible that in the future, such studies will help find early stage markers of cognitive impairment. This could permit an extension of indications for revascularization for the treatment of cognitive impairment in selected patients. The aim of this narrative review is to discuss the current knowledge on the effects of ECAS on brain and cognition by analyzing the main evidence from animal and clinical studies, with a special focus on rs-fc MR studies.

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Effects of Extracranial Carotid Stenosis on Intracranial Blood Flow

Cited by 5 publications

References 0 publications

Asymptomatic Carotid Stenosis is Associated with Gray and White Matter Damage

Asymptomatic Carotid Stenosis is Associated with Gray and White Matter Damage

Correlation between angiographic transit times and neurological status on admission in patients with aneurysmal subarachnoid hemorrhage

Extracranial Carotid Artery Stenosis: The Effects on Brain and Cognition with a Focus on Resting‐State Functional Connectivity

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