Effects of extracts and neferine from the embryo of Nelumbo nucifera seeds on the central nervous system

Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera

“…7) On account of our interest in the sedative activity of this herbal medicine, we evaluated the locomotor activities of the extract of embryo loti and found a main bisbenzylisoquinoline alkaloid, neferine, as an active component. 8) We also demonstrated that antidepressant-like effects of neferine are mediated by the 5-HT 1A receptor. 9) These biological activities of the alkaloids prompted us to further investigate the minor alkaloidal constituents of embryo loti to isolate three novel alkaloids 1-3 together with four known compounds.…”

Synthesis and Pharmacological Activity of Alkaloids from Embryo of Lotus, <i>Nelumbo nucifera</i>

“…Pharmacological Activity Previously we demonstrated that neferine reduces locomotor activity in mice dose dependently, showing that neferine has sedative effects; 11) however, it is not yet clear whether liensinine and isoliensinine, and nelumboferine isolated from the embryo of N. nucifera, have sedative effects or not. In the present study, therefore, we examined the effects of these alkaloids, including a newly synthesized nelumboferine, on locomotor activity in mice.…”

“…10) We also found that neferine decreases locomotor activities in mice. 11,12) These results prompted us to synthesize nelumboferine and to evaluate its pharmacological activity.…”

The Genome-Wide Expression Profile of Nelumbinis semen on Lipopolysaccharide-Stimulated BV-2 Microglial Cells

“…Among 19 chemicals reportedly found in NS, [22][23][24] three chemicals were predicted as central nervous system active compound based on the classification reported by Lobell et al 25) These three compounds included bsitosterol glucopyranoside, armepavine and neferine with brain/blood ratio of 5.304, 0.9931 and 0.47760 respectively.…”