Effects of fabrication conditions on the structure and function of membranes formed from poly(acrylonitrile–vinylchloride)

Broadhead, Kelly W.; Tresco, Patrick A.

doi:10.1016/s0376-7388(98)00125-2

Cited by 32 publications

(10 citation statements)

References 43 publications

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“…These glucose and insulin permeabilities are satisfactory for a clinically useful BAP. The unreinforced APCN membrane showed negligible permeation of bovine serum albumin (BSA) and immunoglobulin G (IgG; Kang et al 2007); therefore, we expect the a Nanomat-reinforced amphiphilic co-network, water-swollen state b Best case scenario: thinnest available alginate membrane (Storrs et al 2001) and the best permeability reported from different sources (Rebecca et al 1996) c Most typical is <1-20 kPa for Ca-alginates (Rebecca et al 1996) d For a 1000 μm thick Ba-cross-linked highest strength alginate membrane e Broadhead and Tresco 1998 reinforced APCN also to prevent the permeation of these molecules.…”

Section: Resultsmentioning

confidence: 99%

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

Erdődi

Kang

Yalcin

et al. 2008

Biomed Microdevices

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This paper describes the design and preparation of the non-biological components (the "hardware") of a conceptually novel bioartificial pancreas (BAP) to correct diabetes. The key components of the hardware are (1) a thin (5-10 microm) semipermeable amphiphilic co-network (APCN) membrane [i.e., a membrane of cocontinuous poly(dimethyl acryl amide) (PDMAAm)/polydimethylsiloxane (PDMS) domains cross-linked by polymethylhydrosiloxane (PMHS)] expressly created for macroencapsulation and immunoisolation of a tissue graft; (2) an electrospun nanomat of PDMS-containing polyurethane to reinforce the water-swollen APCN membrane; and (3) a perforated hollow-ribbon nitinol scaffold to stiffen and provide geometric stability to the construct. The reinforcement of water-swollen hydrogels with an electrospun nanomat is a generally applicable new method for hydrogel reinforcement. Details of device design and preparation are discussed. The advantages and disadvantages of micro- and macro-immunoisolation are analyzed, and the requirements for the ideal immunoisolatory membrane are presented. Burst pressure, and glucose and insulin permeabilities of representative devices have been determined and the effect of device composition and wall thickness on these properties is discussed.

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Section: Resultsmentioning

confidence: 99%

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

Erdődi

Kang

Yalcin

et al. 2008

Biomed Microdevices

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“…In order to meet different requirements imposed by different membrane applications on membrane materials, copolymerizing vinyl monomers such as maleic anhydride [7], ␣-allyl glucoside [8], glycidyl methacylate [9], methacrylic acid [10], N-vinylimidazol [11], 3-sulfoproyl acylate potassium salt [12], hydroxyethyl methacrylate [13], vinyl pyrrolidone [10], acrylic acid [14], acrylamide [15], vinylchloride [16] with acrylonitrile has been used to improve the pervaporation properties, water flux, fouling reducing, biocompatibility, and even for enzyme immobilization. However, as far as we know, there was few report concerning preparation of the charged acrylonitrilebased polymeric membrane though some fragmentary data [12] about synthesize of the charged acrylonitrile-based copolymer was reported.…”

Section: Introductionmentioning

confidence: 99%

The preparation and characterization of novel charged polyacrylonitrile/PES-C blend membranes used for ultrafiltration

Wang

Wu²,

Mo³

et al. 2006

Journal of Membrane Science

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“…The effect of changing the composition of the casting solution is well documented for asymmetric-membranes prepared for separation applications [20][21][22][23][24][25][26][27]. However, there are relatively few quantitative studies illustrating the relationship between the composition of the casting solution and the drug release rate from the asymmetric-membrane coated tablets/capsules [6,16].…”

Section: Effect Of Composition Of the Coating Solutionmentioning

confidence: 99%

In vitro drug release rates from asymmetric-membrane tablet coatings: Prediction of phase-inversion dynamics

Altınkaya

Yenal

2006

Biochemical Engineering Journal

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Most of the controlled-release systems developed for drug delivery applications depend on membrane technology. The dense structure of some membranes used in controlled-release systems can excessively prolong the release of drug due to the low permeability of the coating to drug. To increase the drug release rate, asymmetric-membrane tablet coatings were prepared by a phase-inversion technique using cellulose acetate/acetone/water solution. The roles of the composition of the membrane solution and the evaporation condition on the release rate of drug were determined using in vitro dissolution and morphological studies and predicted phase diagrams. Results show that drug release from asymmetricmembrane based tablet coatings is primarily governed by the dynamics of the phase-inversion process with zero-order or near-zero-order release easily achievable. In an attempt to derive an empirical expression for the release rate of drug as a function of composition of the coating solution, a statistical experimental design was used. Good fit of the experimental data by the empirical expression was obtained. In addition, the predictive capability of the model equation was also found to be satisfactory. Analysis of the significance of each term in the expression indicates that the cellulose acetate:acetone ratio has the most significant influence on the release rate of theophylline.

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Effects of fabrication conditions on the structure and function of membranes formed from poly(acrylonitrile–vinylchloride)

Cited by 32 publications

References 43 publications

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

A novel macroencapsulating immunoisolatory device: the preparation and properties of nanomat-reinforced amphiphilic co-networks deposited on perforated metal scaffold

The preparation and characterization of novel charged polyacrylonitrile/PES-C blend membranes used for ultrafiltration

In vitro drug release rates from asymmetric-membrane tablet coatings: Prediction of phase-inversion dynamics

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